ID   A0A2C9T3Y6_9MYCO        Unreviewed;       341 AA.
AC   A0A2C9T3Y6;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Putative zinc-binding alcohol dehydrogenase {ECO:0000313|EMBL:GAY18767.1};
DE            EC=1.1.1.1 {ECO:0000313|EMBL:GAY18767.1};
GN   ORFNames=MSZK_54930 {ECO:0000313|EMBL:GAY18767.1};
OS   Mycobacterium sp. shizuoka-1.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=2039281 {ECO:0000313|EMBL:GAY18767.1, ECO:0000313|Proteomes:UP000223528};
RN   [1] {ECO:0000313|EMBL:GAY18767.1, ECO:0000313|Proteomes:UP000223528}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=shizuoka-1 {ECO:0000313|Proteomes:UP000223528};
RA   Yoshida M., Izumiyama S., Fukano H., Sugiyama K., Suzuki M., Shibayama K.,
RA   Hoshino Y.;
RT   "Draft genome sequence of Mycobacterium sp. shizuoka-1.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU361277}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAY18767.1}.
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DR   EMBL; BEWG01000113; GAY18767.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2C9T3Y6; -.
DR   OrthoDB; 241504at2; -.
DR   Proteomes; UP000223528; Unassembled WGS sequence.
DR   GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR42813:SF2; DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED; 1.
DR   PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:GAY18767.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000223528};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          10..339
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   341 AA;  34553 MW;  8127C01EBEA4DAA8 CRC64;
     MRAVLIDTPG SVRVDEWPDP VLPGPTGAIV SVTAAAICGS DLHFYEGDYP LFAPVSLGHE
     AIGTVVEVGP DVHSVTVGDQ VMVSSVAGCG ACAGCATKDP ILCASGPQVF GSGLLGGAQA
     ELMAVPAADF QLLRMPEGIS TEQALLLTDN LATGWAAAKR ADIPLGGTAV VIGLGAVGLC
     AVRSALFLGA ARVYAVDPVA QRRDRAARLG AIAIEPAAAP TVTAATGGLG AHSVIDAVGN
     DTTLDDALAT VRAGGTVSVV GVHNLNPYPF PALTALLRSL TFRATTAPVQ QTWPELIPLL
     QTGRLEVDDI FTTRLPLGQA AEGYAAVAAR SGDVVKVLLT P
//