ID A0A2C9TZB9_MANES Unreviewed; 933 AA.
AC A0A2C9TZB9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Glutamate receptor {ECO:0000256|PIRNR:PIRNR037090};
GN ORFNames=MANES_18G003400 {ECO:0000313|EMBL:OAY22500.1};
OS Manihot esculenta (Cassava) (Jatropha manihot).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae;
OC Manihot.
OX NCBI_TaxID=3983 {ECO:0000313|EMBL:OAY22500.1, ECO:0000313|Proteomes:UP000091857};
RN [1] {ECO:0000313|EMBL:OAY22500.1, ECO:0000313|Proteomes:UP000091857}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AM560-2 {ECO:0000313|Proteomes:UP000091857};
RC TISSUE=Leaf {ECO:0000313|EMBL:OAY22500.1};
RA Bredeson J.V., Prochnik S.E., Lyons J.B., Schmutz J., Grimwood J.,
RA Vrebalov J., Bart R.S., Amuge T., Ferguson M.E., Green R., Putnam N.,
RA Stites J., Rounsley S., Rokhsar D.S.;
RT "WGS assembly of Manihot esculenta.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Glutamate-gated receptor that probably acts as non-selective
CC cation channel. {ECO:0000256|PIRNR:PIRNR037090}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685, ECO:0000256|PIRNR:PIRNR037090}.
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DR EMBL; CM004404; OAY22500.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2C9TZB9; -.
DR STRING; 3983.A0A2C9TZB9; -.
DR EnsemblPlants; OAY22500; OAY22500; MANES_18G003400.
DR Gramene; OAY22500; OAY22500; MANES_18G003400.
DR Proteomes; UP000091857; Chromosome lg18.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR CDD; cd13686; GluR_Plant; 1.
DR CDD; cd19990; PBP1_GABAb_receptor_plant; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 3.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR044440; GABAb_receptor_plant_PBP1.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR017103; Iontropic_Glu_rcpt_pln.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966:SF422; KAINATE-TYPE IONOTROPIC GLUTAMATE RECEPTOR SUBUNIT 1D; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PIRSF; PIRSF037090; Iontro_Glu-like_rcpt_pln; 1.
DR PRINTS; PR01176; GABABRECEPTR.
DR PRINTS; PR00248; GPCRMGR.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR037090-50};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|PIRNR:PIRNR037090};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|PIRNR:PIRNR037090};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|PIRNR:PIRNR037090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR037090};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037090};
KW Reference proteome {ECO:0000313|Proteomes:UP000091857};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR037090}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..933
FT /note="Glutamate receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012835830"
FT TRANSMEM 579..607
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 649..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 829..849
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 468..809
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT REGION 881..933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 881..916
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..933
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 758..812
FT /evidence="ECO:0000256|PIRSR:PIRSR037090-50"
SQ SEQUENCE 933 AA; 103109 MW; B2610DC2628D6923 CRC64;
MNAIVLLSFF FAVCGLFSSI HSRNFTSRPA VVNIGAIFSF ETTIGRVAKI AIEEAVKDVN
ANSSILRGSK LVVSMHSSNC SGFTGMVEAL RFMETDAVAI IGPQSSVVAH IISQVVNELR
VPLLSFAATD PTLDSLQFPF FVRTTRSDLY QMAAIAEIVD YYGWKQVIAI FIDDDNGRNG
ILALSDKLAE RRSKISYKVG IPPDSGVTRG DIMDILVKVA LMEPRVVVLH VNPKLGFSIF
SVAKYLGMMS NGYVWIATDW LSSYLDSSSP LPSETMNIMQ GVLALRQYTP DSDRKRSFSS
RWSNLTGGSL GLNSYGLYAY DSVWLVAHAI DAFFEQGGVI SFSNDSRLRS EGGDLHLDAM
SIFDDGLLLL KNVLRSDLVG LTGPLKFDSD RSLILPAYDV INVIGTGYRQ IGYWSNYSGL
STVPPETFYM RPPNRSSANQ QLYSVIWPGE TVLKPRGWVF PNNGKQLRIG VPIRVSFKEF
VTKVQGTDMF KGFCIDVFTA AVSLLPYAVP YQFIPFGNGK ENPSYTELVN LITTGFFDAV
VGDIAIVTNR TKIVDYTQPF VASGLVVVAP FRKLNSGAWA FLLPFSPLMW IVTACFFIGV
GTVVWILEHR INDEFRGPPK RQIITILWFS LSTLFFAHRE NTVSTLGRFV LIIWLFVVLI
INSSYTASLT SILTVQQLFS PISGIDSLKE SDEPIGYQVG SFAEYYLSQE LGISKSRLVP
LGSPEAYARA LELGPKKGGV AAVVDELPYV ELFLSTQCTF RIVGQEFTKS GWGFAFPRDS
PLAIDMSTAI LALSENGDLQ RIHDKWLMHS GCSSDSTELE SDRLQLKSFS GLFLICGLAC
FLALFIYFLQ IIRQLYSAPT VEAASPVQGS SRSGRLHRLL SLMDEKEDQS RQKNKRRKVE
RSLSENDGDA KSGSNTKRKG IEMTSGSNIN PIS
//
