ID A0A2C9U7P5_MANES Unreviewed; 504 AA.
AC A0A2C9U7P5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Protein DETOXIFICATION {ECO:0000256|RuleBase:RU004914};
DE AltName: Full=Multidrug and toxic compound extrusion protein {ECO:0000256|RuleBase:RU004914};
GN ORFNames=MANES_16G008000 {ECO:0000313|EMBL:OAY25935.1};
OS Manihot esculenta (Cassava) (Jatropha manihot).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae;
OC Manihot.
OX NCBI_TaxID=3983 {ECO:0000313|EMBL:OAY25935.1, ECO:0000313|Proteomes:UP000091857};
RN [1] {ECO:0000313|EMBL:OAY25935.1, ECO:0000313|Proteomes:UP000091857}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AM560-2 {ECO:0000313|Proteomes:UP000091857};
RC TISSUE=Leaf {ECO:0000313|EMBL:OAY25935.1};
RA Bredeson J.V., Prochnik S.E., Lyons J.B., Schmutz J., Grimwood J.,
RA Vrebalov J., Bart R.S., Amuge T., Ferguson M.E., Green R., Putnam N.,
RA Stites J., Rounsley S., Rokhsar D.S.;
RT "WGS assembly of Manihot esculenta.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000256|ARBA:ARBA00010199,
CC ECO:0000256|RuleBase:RU004914}.
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DR EMBL; CM004402; OAY25935.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2C9U7P5; -.
DR EnsemblPlants; OAY25935; OAY25935; MANES_16G008000.
DR Gramene; OAY25935; OAY25935; MANES_16G008000.
DR OMA; TWYSQIL; -.
DR OrthoDB; 10858at2759; -.
DR Proteomes; UP000091857; Chromosome lg16.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR11206; MULTIDRUG RESISTANCE PROTEIN; 1.
DR PANTHER; PTHR11206:SF140; PROTEIN DETOXIFICATION 37; 1.
DR Pfam; PF01554; MatE; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|RuleBase:RU004914};
KW Reference proteome {ECO:0000313|Proteomes:UP000091857};
KW Transmembrane {ECO:0000256|RuleBase:RU004914};
KW Transmembrane helix {ECO:0000256|RuleBase:RU004914}.
FT TRANSMEM 49..67
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 128..152
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 199..222
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 228..252
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 312..334
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 355..379
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 399..418
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 425..447
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 453..476
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
SQ SEQUENCE 504 AA; 54741 MW; 813E2042C4704E26 CRC64;
METRSELHEP ILGSLHESTE HYEVKSELEK VLTDTQLPYF KRLRIASWIE LKLLFPLAGP
AVFVYMINNF MSQSTRVFAG HLGNLELAAA SLGNGGIQLF AYGLMLGMGS AVETLCGQAY
GAHRNEMLGI YLQRAIVVLT LTAIPMTVIY LLSKPALLLL GEPKKVASAA AVFVYGLIPQ
IFAYAVNFPI QKFLQAQSIV YPSAIISAAT LGVHLLVTWV ALFKPGMGLV GASLALSLSW
WIIVVAQFVY IVKSDRCKET WTGFSLQAFS GLWPFVKLSA GSAVMLCLET WYSQILILIA
GLLDNPEIAL DSLAVCLSIN GLMFMVSVGF NAAASVRVSN ELGAGNPKSA EFSVFIVNLV
SFIIAVIEAA VVLALRHLIS YAFTSGETVA DAVAELSPFL GITLILNGIQ PVLSGVAVGC
GWQAFVAYVN VGCYYVVGIP LGFLLGFKFD LGAKGIWCGM IGGTLMQTMI LLWVTIRTNW
NEEVEKARMR LNCWENNEPQ EAKI
//