ID A0A2C9UNM2_MANES Unreviewed; 1100 AA.
AC A0A2C9UNM2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN ORFNames=MANES_13G002600 {ECO:0000313|EMBL:OAY32244.1};
OS Manihot esculenta (Cassava) (Jatropha manihot).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae;
OC Manihot.
OX NCBI_TaxID=3983 {ECO:0000313|EMBL:OAY32244.1, ECO:0000313|Proteomes:UP000091857};
RN [1] {ECO:0000313|EMBL:OAY32244.1, ECO:0000313|Proteomes:UP000091857}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AM560-2 {ECO:0000313|Proteomes:UP000091857};
RC TISSUE=Leaf {ECO:0000313|EMBL:OAY32244.1};
RA Bredeson J.V., Prochnik S.E., Lyons J.B., Schmutz J., Grimwood J.,
RA Vrebalov J., Bart R.S., Amuge T., Ferguson M.E., Green R., Putnam N.,
RA Stites J., Rounsley S., Rokhsar D.S.;
RT "WGS assembly of Manihot esculenta.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR EMBL; CM004399; OAY32244.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2C9UNM2; -.
DR EnsemblPlants; OAY32244; OAY32244; MANES_13G002600.
DR Gramene; OAY32244; OAY32244; MANES_13G002600.
DR Proteomes; UP000091857; Chromosome lg13.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF579; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000091857}.
FT DOMAIN 21..187
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1100 AA; 126219 MW; C1AF662BE499B82A CRC64;
MEKFKGFKLK QGDLKASRSK WKYDVFLNFR GEDIRKNFVS HLYKRLCDEG IITFKDDHSL
ETGQSISEAL PKEIGESRIL IIIFSKNYVS STWCLNELVQ ILECKKAGRQ IALPIFYNVT
PGQVRKQCGD FREAFAVHEE HFKENIEKVE RWRAAMTEAA NLKGWELQHR EESEFIEEIV
KDIISKLEQF SSDIPKGLVG MESRIEKMRS YLDMGQSNKV KIIGVCGMGG IGKTTIASVV
YKQMCSKFEG SSFLADVREA SKRYDGLVSL QSKLLSAILN RDVKVHDVHK GTEDIRKKLR
SKKVLVILDD VDEVKQLECL IGKRDENWFG EGSRIIITTR NRHLLDQHGV DDAYMLEELE
VDEAFELFFL NAFKNDCPTL DHVMLSVQFL RYASGLPLAL SVLGSYLYAK SIEEWKSALE
KLKEIPNEEI LKKLEISLDG LDETEKKIFL DIACFFNGAD ENYVTKVLES CGFYPKTGIR
ELINRSLLTI SDKTVWMHDL LQEMGRDIVR RECTKCGQRS RIWLYEDLDH VLTNDTSCVC
HNGRQSISAK GFTKMKCLRL LILQIEHNFE GLEYLSNELR YLEWREYPFK SFPSTFQPNK
LVELHMPHSN LKNFLKAIKP VESLKIINLS FSTKLIKTPD FSKFPNLEEL NLQGCTKLVE
VHQSIGVLTR LVSLNMQDCK NLVNLPDGVW NLQSLEIVNL GGCSKLLKRL GLVARQMWCF
TAFPSLMHLD LSYCNLPEGA IPNDMSCLQL LEYLNLSGNP ILSIPSSICQ LSKLKGLYLY
DCTELKTLPD LPSNIERLST SNCTSLRTLP PLVQLCKLEN FQCSNCKSLQ SVPDLPSSVQ
HLKMENCTAL ETLPNLFEKH NVEKNFFISF SNCSKLKYCQ SKISVGFTWL RSYLLWLYEV
RKLLKLQESS PSEAEFEENF FLNEAKIILQ TRIPAATSLP CFYICFPGST IPEWFKYQGE
EGELRIKLPP DEDWGKIAGF AVCCVVEDGN VIKDNEWQIA VVIEGKQVSC WGNRVPAGAS
QVTSDHLSLF FQVNFFRFFQ VNNHRESNRE CTPTELLLNF WPEGKIKNCG IRIVHDEEIE
EMIRLNKALE DMGKVEEEDN
//
