ID   A0A2C9UP49_MANES        Unreviewed;       359 AA.
AC   A0A2C9UP49;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein {ECO:0000259|Pfam:PF13532};
GN   ORFNames=MANES_13G011800 {ECO:0000313|EMBL:OAY32354.1};
OS   Manihot esculenta (Cassava) (Jatropha manihot).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae;
OC   Manihot.
OX   NCBI_TaxID=3983 {ECO:0000313|EMBL:OAY32354.1, ECO:0000313|Proteomes:UP000091857};
RN   [1] {ECO:0000313|EMBL:OAY32354.1, ECO:0000313|Proteomes:UP000091857}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. AM560-2 {ECO:0000313|Proteomes:UP000091857};
RC   TISSUE=Leaf {ECO:0000313|EMBL:OAY32354.1};
RA   Bredeson J.V., Prochnik S.E., Lyons J.B., Schmutz J., Grimwood J.,
RA   Vrebalov J., Bart R.S., Amuge T., Ferguson M.E., Green R., Putnam N.,
RA   Stites J., Rounsley S., Rokhsar D.S.;
RT   "WGS assembly of Manihot esculenta.";
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|PIRSR:PIRSR604574-2};
CC       Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR604574-2};
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DR   EMBL; CM004399; OAY32354.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2C9UP49; -.
DR   STRING; 3983.A0A2C9UP49; -.
DR   EnsemblPlants; OAY32354; OAY32354; MANES_13G011800.
DR   Gramene; OAY32354; OAY32354; MANES_13G011800.
DR   Proteomes; UP000091857; Chromosome lg13.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0008198; F:ferrous iron binding; IBA:GO_Central.
DR   GO; GO:0035516; F:oxidative DNA demethylase activity; IBA:GO_Central.
DR   GO; GO:0035515; F:oxidative RNA demethylase activity; IBA:GO_Central.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0035513; P:oxidative RNA demethylation; IBA:GO_Central.
DR   GO; GO:0035552; P:oxidative single-stranded DNA demethylation; IBA:GO_Central.
DR   Gene3D; 2.60.120.590; Alpha-ketoglutarate-dependent dioxygenase AlkB-like; 1.
DR   InterPro; IPR004574; Alkb.
DR   InterPro; IPR027450; AlkB-like.
DR   InterPro; IPR037151; AlkB-like_sf.
DR   PANTHER; PTHR16557; ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED; 1.
DR   PANTHER; PTHR16557:SF11; ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB; 1.
DR   Pfam; PF13532; 2OG-FeII_Oxy_2; 1.
DR   SUPFAM; SSF51197; Clavaminate synthase-like; 1.
PE   4: Predicted;
KW   Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Iron {ECO:0000256|PIRSR:PIRSR604574-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR604574-2};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000091857}.
FT   DOMAIN          181..328
FT                   /note="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"
FT                   /evidence="ECO:0000259|Pfam:PF13532"
FT   BINDING         262
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604574-2"
FT   BINDING         264
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604574-2"
FT   BINDING         318
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604574-2"
SQ   SEQUENCE   359 AA;  40597 MW;  6876E6EC6B0EABC8 CRC64;
     MYGPDRVTDE AVSERTAFRR AEKQYKLYYD QDSKSSKNRK KRPKRVDLSE VLDFKTISES
     YDKNGDLPPG IVPFQCGFDR PVFCLQNCPG FYFIPGALSI EEQCRWIREG LISFPQPPNR
     TNHNAIYGPI HDLFIASKER KVLVEDENTL QSLDSGSNAC VSNEDSHRWE FCEEHIALSR
     GKTHKSISAS VLIRKLRWST LGLQFDWSKR NYNVSLPHNK IPDALCQLAK RLAAPAMPMG
     EEFHPEAAIV NYFGLGDMLG GHLDDMEADW SKPIVSMSLG CKAIFLLGGK SREDPPFAMF
     LRSGDVVLMA GEARECFHGV PRIFTDEENA EITPLEPLNI ENVKVASGLM ENDEVFEDI
//