ID   A0A2C9UY49_MANES        Unreviewed;      1152 AA.
AC   A0A2C9UY49;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN   ORFNames=MANES_11G033500 {ECO:0000313|EMBL:OAY36601.1};
OS   Manihot esculenta (Cassava) (Jatropha manihot).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae;
OC   Manihot.
OX   NCBI_TaxID=3983 {ECO:0000313|EMBL:OAY36601.1, ECO:0000313|Proteomes:UP000091857};
RN   [1] {ECO:0000313|EMBL:OAY36601.1, ECO:0000313|Proteomes:UP000091857}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. AM560-2 {ECO:0000313|Proteomes:UP000091857};
RC   TISSUE=Leaf {ECO:0000313|EMBL:OAY36601.1};
RA   Bredeson J.V., Prochnik S.E., Lyons J.B., Schmutz J., Grimwood J.,
RA   Vrebalov J., Bart R.S., Amuge T., Ferguson M.E., Green R., Putnam N.,
RA   Stites J., Rounsley S., Rokhsar D.S.;
RT   "WGS assembly of Manihot esculenta.";
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC       (CIA) complex, a multiprotein complex that mediates the incorporation
CC       of iron-sulfur cluster into apoproteins specifically involved in DNA
CC       metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC       adapter between early-acting CIA components and a subset of cellular
CC       target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU367072}.
CC   -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC       {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
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DR   EMBL; CM004397; OAY36601.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2C9UY49; -.
DR   STRING; 3983.A0A2C9UY49; -.
DR   EnsemblPlants; OAY36601; OAY36601; MANES_11G033500.
DR   Gramene; OAY36601; OAY36601; MANES_11G033500.
DR   OMA; FSFMPEF; -.
DR   OrthoDB; 38995at2759; -.
DR   Proteomes; UP000091857; Chromosome lg11.
DR   GO; GO:0097361; C:CIA complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IBA:GO_Central.
DR   GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039920; MET18/MMS19.
DR   InterPro; IPR024687; MMS19_C.
DR   InterPro; IPR029240; MMS19_N.
DR   PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR   PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR   Pfam; PF12460; MMS19_C; 1.
DR   Pfam; PF14500; MMS19_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|RuleBase:RU367072};
KW   DNA repair {ECO:0000256|RuleBase:RU367072};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW   Reference proteome {ECO:0000313|Proteomes:UP000091857};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          46..313
FT                   /note="MMS19 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14500"
FT   DOMAIN          688..1100
FT                   /note="MMS19 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12460"
SQ   SEQUENCE   1152 AA;  127556 MW;  2093F0B1347C96AF CRC64;
     MADPSQLIKH IESYVDSSRS PTQQASSLDA IVSLLKNDAV TIGSLVKEME MYLTVTDDIL
     RARGILLLGE ALNRLSSKPL DNATIHSLIT FFTERLADWR ALRGALVGCL ALLRRKSIGI
     VTNIDAKAVA KSYLQNLQVQ SLAQHDRKLC FELLECLLEH YPEAAASLGE DLIYGICEAI
     DGEKDPQCLM LTFHIVELLV QLFPDPSGPI SSFAGDLFGI LGCYFPIHFT HPKAEDIDVQ
     RDDLSRALML AFSSTPLFEP FAMPLLLEKL SSSLPSAKVD SLKYLSCCTL KFGADRIAKH
     AGAIWSSLKD AIYSSGEELI PTFNSEPTSN SDFQKNQIAA EALALLEKVI VQNTDLFLSM
     IIGDEEVNMI FNNITNYESC NAISLQSKQK LHMVGHILNV SAKASLSSCN RVFENFFPRL
     MEVLVLSVEK TSGACHSNDS CVNSSKISYG SLYLCVELLG ACRDLFTTSE NLTPQIISPN
     EKCCCLLQCY STSLTRIFSS ILATCTSGPS YDADMYLGVK GLQILATFPG GYLLMSKSTF
     DDVLMTFMSI ITVDFNKTLL WKHALKALVN IGSFIHGCNE SEQASYMDIV VDKIILLALS
     ANNSMPWPLK LTAISSISTS GQKYMLKIVL WLEEMILTNL SEFYVEGHQK SAEIIIQLFE
     CYSNELLPWI QKNEGLEEVL QFVVNIWNQI ESCMAFSVRV HEKELIDVTM KFMKLAVACC
     SVESQNMIIH KAFSVLSSSP SLQLKESLSD ISVQRERLAP TQETDKFSTR DEWILSLFAS
     VIIAVRPQTH IPNTRTVLHL FITALLKGYV TAAQALGSLL NKLDLKSNGT SISGHCTLEE
     AIDIIFSSKS FDNVPLGGHG ITNNGDEISF PNLCLGAASN GLQQINVIVG LAWVGKGLLM
     RGHEKAKNIT MVFLKCFLLD SGIGTLPLKQ VSENSCKQDV HHSVMKASAD AFQILMTDSE
     LCLNRKFHAI IRPLYKQRFY SSLMPILQPL INEADSSFSR SMLYRAFAHV IIDTPLSVVL
     NDAKKLIPLL LDGLALLCKD ILDKDIMYGL LLVLSGILTH KNGKEAAIDN AHIIIKCLIE
     LVEYPHMMLV RETAIQCLVA MSELPHTRIY PLRIQVLGAI SKALDDPKRA VRQEAVRCRQ
     AWASIASRSL HF
//