ID   A0A2C9V685_MANES        Unreviewed;       737 AA.
AC   A0A2C9V685;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   RecName: Full=DUF4220 domain-containing protein {ECO:0000259|Pfam:PF13968};
GN   ORFNames=MANES_10G138300 {ECO:0000313|EMBL:OAY39966.1};
OS   Manihot esculenta (Cassava) (Jatropha manihot).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae;
OC   Manihot.
OX   NCBI_TaxID=3983 {ECO:0000313|EMBL:OAY39966.1, ECO:0000313|Proteomes:UP000091857};
RN   [1] {ECO:0000313|EMBL:OAY39966.1, ECO:0000313|Proteomes:UP000091857}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. AM560-2 {ECO:0000313|Proteomes:UP000091857};
RC   TISSUE=Leaf {ECO:0000313|EMBL:OAY39966.1};
RA   Bredeson J.V., Prochnik S.E., Lyons J.B., Schmutz J., Grimwood J.,
RA   Vrebalov J., Bart R.S., Amuge T., Ferguson M.E., Green R., Putnam N.,
RA   Stites J., Rounsley S., Rokhsar D.S.;
RT   "WGS assembly of Manihot esculenta.";
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CM004396; OAY39966.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2C9V685; -.
DR   STRING; 3983.A0A2C9V685; -.
DR   EnsemblPlants; OAY39966; OAY39966; MANES_10G138300.
DR   Gramene; OAY39966; OAY39966; MANES_10G138300.
DR   Proteomes; UP000091857; Chromosome lg10.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR025315; DUF4220.
DR   InterPro; IPR007658; DUF594.
DR   PANTHER; PTHR31325; OS01G0798800 PROTEIN-RELATED; 1.
DR   PANTHER; PTHR31325:SF222; PROTEIN, PUTATIVE (DUF594)-RELATED; 1.
DR   Pfam; PF13968; DUF4220; 1.
DR   Pfam; PF04578; DUF594; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000091857};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        49..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        117..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          52..302
FT                   /note="DUF4220"
FT                   /evidence="ECO:0000259|Pfam:PF13968"
SQ   SEQUENCE   737 AA;  84263 MW;  6B4DC93932B234D1 CRC64;
     MANSISERVK YMWEHWNIRV AVQFSLALQI LLIGLAPSRK WTSNKLVNLL VWSSYLLADA
     TANFAVGLIF NGKSSPPDHV SPAENSKLLA FWAPFLLLHL GGPDTITAFA LEDNQLWLRH
     LLAFIVRFAT TGYVFFRNLR KNKVIIPTAL LFLAGTIKYL ERTYSLYLAS KDKFRASMLR
     KPDPGINFAK FAEVVASKKP EELPEVKTEN RREAMVTDAV TDFCLDIRKL EDLDVVQEAH
     KYFKIFKGLI VGIIYSFEQR DKSRHFFNSI SAEDAFKVIA AELNFLYEVL YTKVVVVHSM
     LGLDGVSILM AIFSNWTIVA VLESMPRPED RSHWVLRLFS KFLILKRPKM YVCEPDKHTT
     LLTCIPFRSW SESVPGYNVI RYCLKQRPRK IHNVMHSIQR VICYLGIDKI ANQCCGIINK
     VGQCINISSR KVIQVLFDEE IQVLLIDNVI PCLNSFKKGL IQCLKSLKRG LIDLVGLKDF
     LDELKYASSK PLTVELWAFI FSELQMKSWL IDDPETARKI CSARGEWVLQ SHGLDKIRSD
     LMAYVVDVRY DESVLMWHIA TELLCNDTKG IDNCSNEREF SKILSDYMLY LLIMQPTMMA
     AVAGISKLRF EDTCADAKRF FKKRGIRSNN VKKACRLILE VNTEFKPAQV KRDGSLSVLF
     TASMLAKELR KLREQKWKIL SQVWVEMLSY AASHCNATSH AVQLSKGGEL VTFVWLLMSQ
     FGVGNQFQSN CSLLLQG
//