ID A0A2C9V7D9_MANES Unreviewed; 1223 AA.
AC A0A2C9V7D9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=MANES_10G113600 {ECO:0000313|EMBL:OAY39669.1};
OS Manihot esculenta (Cassava) (Jatropha manihot).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae;
OC Manihot.
OX NCBI_TaxID=3983 {ECO:0000313|EMBL:OAY39669.1, ECO:0000313|Proteomes:UP000091857};
RN [1] {ECO:0000313|EMBL:OAY39669.1, ECO:0000313|Proteomes:UP000091857}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AM560-2 {ECO:0000313|Proteomes:UP000091857};
RC TISSUE=Leaf {ECO:0000313|EMBL:OAY39669.1};
RA Bredeson J.V., Prochnik S.E., Lyons J.B., Schmutz J., Grimwood J.,
RA Vrebalov J., Bart R.S., Amuge T., Ferguson M.E., Green R., Putnam N.,
RA Stites J., Rounsley S., Rokhsar D.S.;
RT "WGS assembly of Manihot esculenta.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC protein kinase family. ROCO subfamily. {ECO:0000256|ARBA:ARBA00008171}.
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DR EMBL; CM004396; OAY39669.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2C9V7D9; -.
DR EnsemblPlants; OAY39669; OAY39669; MANES_10G113600.
DR Gramene; OAY39669; OAY39669; MANES_10G113600.
DR Proteomes; UP000091857; Chromosome lg10.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047117; PERK1-13-like.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR47982; PROLINE-RICH RECEPTOR-LIKE PROTEIN KINASE PERK4; 1.
DR PANTHER; PTHR47982:SF40; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000091857};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 62..332
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 90
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1223 AA; 139082 MW; DD4D4B2B8821AD2C CRC64;
MNIAEDKMAS TESNSPSAPG EKQSVSPSQH TDLTESTSSE NFQADTLRKF SYSELAEATN
SFSNSVCLGG GTFGIVYRGC LPIGDFAVKK LYYTGDGQHI EEFENRINVI GMARHRHLVS
LIGYCCEEYD RLLVLEFVPN RSLRFHLRDA ERRSKLKWSK RMKIAIGSAK GLKYLHEYCE
PKIIHGGIKS DNILLDRNFE PKVADFGLAI LLEGYDAARI YVDSNISDLE KISELDIYSF
GVTLLELITG RKIYEDEYIV KWARPLMIKG DSINVDYDGL VDSTLKGQYD QSEVERIIYC
IAASIYTPSS KLRPKMGQIL EALEGLIPHQ QLWAVEEHKE ITEVSNQLWS KATPSQGTGP
KIMQIQEMPA ESNYSALEPA AMLSETSLEA TAQSAIPPSR LMKIYHILNK IVSRIKNSNV
STIGVYGGEG IGKTTLSEAL KIQPAIRDMF HFVIWVSVPK VWNLREVQLQ IGRQLPLSGK
KRINKYTLMS FLESVKFILI LDGVNGFISL NIVGIPEPTP ENGSKIVLTA RSAEVCDRMS
ADLKINLEDL FRELFCENVG EIVYSFKLQP LAPKVVDLCC NHSHAIFLMS KALKDESDVR
VWKNAVDMLS RQPASPEQEI ENIMVNILKF SYDRLPDDTT RRCLKNCALF FEKQEIARES
LIDNWISDDL MDMYQKGQKV IETLVTAGLL ESSEDGQVFK LHEIDSSLLL EHVFPSRLFL
RRKGSTLTEL LMDENWENSD EIYLMDNELT ELSEKLSSQA QALFLQRNLK LRKISDTFFQ
DMLALQILNL SVTSIKFLPD SLFGLVNLKR LSLNRCVLLK LLPSRVGDLS CLEVLHLEGT
AIVALPREVE HLKNLTSLKV SFREPVIFDH PKKMIPDGVI KKLSKLKKLR IDVSPEDGRW
KASVVSIVLE VCTLTTLDTL QFYFPNVKLL SQINWDTTPT SPPLSHFKFI VGDHTNRIIC
RLPHDVDVEL GRYDKCLKYV NGEGAPEEIK KVLRHTSAFF LDRNMSVEKL SEFEISNMMQ
LKCCVAGECD KLQTIIEGDQ MVTSASGEVE LGLESLEYLY IYYAKSLRSI CEGRLDNSSF
KKLKYLTLHM CPELTIIFMP ELLVNLSSLE ELIVDDCSEV KSLVHCKDNE HEIKHILPAL
KKISFHFLPE LDSISDVVSI APRIEWMDFY YCPNLKSLPI SKAIHTKLRQ IKGEESWWQS
LEWQNNEQDS NWEDIFTPVD EWD
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