ID   A0A2C9VHQ1_MANES        Unreviewed;       449 AA.
AC   A0A2C9VHQ1;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Magnesium transporter {ECO:0000256|RuleBase:RU366041};
GN   ORFNames=MANES_07G020300 {ECO:0000313|EMBL:OAY44962.1};
OS   Manihot esculenta (Cassava) (Jatropha manihot).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae;
OC   Manihot.
OX   NCBI_TaxID=3983 {ECO:0000313|EMBL:OAY44962.1, ECO:0000313|Proteomes:UP000091857};
RN   [1] {ECO:0000313|EMBL:OAY44962.1, ECO:0000313|Proteomes:UP000091857}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. AM560-2 {ECO:0000313|Proteomes:UP000091857};
RC   TISSUE=Leaf {ECO:0000313|EMBL:OAY44962.1};
RA   Bredeson J.V., Prochnik S.E., Lyons J.B., Schmutz J., Grimwood J.,
RA   Vrebalov J., Bart R.S., Amuge T., Ferguson M.E., Green R., Putnam N.,
RA   Stites J., Rounsley S., Rokhsar D.S.;
RT   "WGS assembly of Manihot esculenta.";
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Magnesium transporter that may mediate the influx of
CC       magnesium. {ECO:0000256|RuleBase:RU366041}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU366041}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU366041}.
CC   -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC
CC       1.A.35.5) family. {ECO:0000256|ARBA:ARBA00007535,
CC       ECO:0000256|RuleBase:RU366041}.
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DR   EMBL; CM004393; OAY44962.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2C9VHQ1; -.
DR   STRING; 3983.A0A2C9VHQ1; -.
DR   EnsemblPlants; OAY44962; OAY44962; MANES_07G020300.
DR   Gramene; OAY44962; OAY44962; MANES_07G020300.
DR   OMA; QWLPVPE; -.
DR   OrthoDB; 73031at2759; -.
DR   Proteomes; UP000091857; Chromosome lg7.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015693; P:magnesium ion transport; IBA:GO_Central.
DR   CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR   Gene3D; 2.40.128.330; -; 1.
DR   Gene3D; 1.20.58.340; Magnesium transport protein CorA, transmembrane region; 1.
DR   InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR   InterPro; IPR039204; MRS2-like.
DR   PANTHER; PTHR13890:SF2; MAGNESIUM TRANSPORTER MRS2-4-RELATED; 1.
DR   PANTHER; PTHR13890; RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL; 1.
DR   Pfam; PF01544; CorA; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Ion transport {ECO:0000256|RuleBase:RU366041};
KW   Magnesium {ECO:0000256|RuleBase:RU366041};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU366041};
KW   Reference proteome {ECO:0000313|Proteomes:UP000091857};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU366041};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU366041}; Transport {ECO:0000256|RuleBase:RU366041}.
FT   TRANSMEM        385..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366041"
FT   TRANSMEM        418..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366041"
FT   REGION          1..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          247..281
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        23..39
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..64
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   449 AA;  50165 MW;  E5D6054B866F1FBA CRC64;
     MGRGSSIFSK SSRRRLKKKS GPPSPPVLTP PPPPPLRAVS SPQQLTDGSN NNNNNNNNSL
     IAGTGAKTKK KAVGARLWMR FDRFGISELM ECDKSTIIKR VAIPARDLRI LGPVFSHSSN
     ILAREKAMVV NLEFIRAIVT AEEVLILDPL CQEVLPFVDQ LRQQIPLKRS VNTQEAGHTD
     TQDNEVHSTE AAEGLQCELP FEFQVLEIAL EVVCTYLDSN VADLERDAYP VLDELARNVS
     TKNLEHVRSL KSNLTRLLAR VQKVRDEIEH LLDDNEDMAD LYLTRKWVQN QQSEALLGTA
     ASNSIITFAP PLRRLSSSHS ASLVTGSILG ENDVEDLEML LEAYFMQLDG TRNKILSVRE
     YIDDTEDYVN IQLDQQRNEL IQLQLTLTIA SFAITMDTLV ASFFGMNIPC RLYEIQGIFG
     YFVGATSAAC FLLFLLVLGY ARWKKLLGS
//