ID A0A2C9VRS0_MANES Unreviewed; 2238 AA.
AC A0A2C9VRS0;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=MANES_06G105000 {ECO:0000313|EMBL:OAY47774.1};
OS Manihot esculenta (Cassava) (Jatropha manihot).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae;
OC Manihot.
OX NCBI_TaxID=3983 {ECO:0000313|EMBL:OAY47774.1, ECO:0000313|Proteomes:UP000091857};
RN [1] {ECO:0000313|EMBL:OAY47774.1, ECO:0000313|Proteomes:UP000091857}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AM560-2 {ECO:0000313|Proteomes:UP000091857};
RC TISSUE=Leaf {ECO:0000313|EMBL:OAY47774.1};
RA Bredeson J.V., Prochnik S.E., Lyons J.B., Schmutz J., Grimwood J.,
RA Vrebalov J., Bart R.S., Amuge T., Ferguson M.E., Green R., Putnam N.,
RA Stites J., Rounsley S., Rokhsar D.S.;
RT "WGS assembly of Manihot esculenta.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CM004392; OAY47774.1; -; Genomic_DNA.
DR EnsemblPlants; OAY47774; OAY47774; MANES_06G105000.
DR Gramene; OAY47774; OAY47774; MANES_06G105000.
DR Proteomes; UP000091857; Chromosome lg6.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05171; PIKKc_ATM; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR038980; ATM_plant.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR044107; PIKKc_ATM.
DR PANTHER; PTHR37079; SERINE/THREONINE-PROTEIN KINASE ATM; 1.
DR PANTHER; PTHR37079:SF4; SERINE_THREONINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000091857};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1401..1775
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 1881..2193
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2206..2238
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 2238 AA; 253464 MW; A5C9B8D45C21FD31 CRC64;
MQADAALMLL GSIISIDLKN TFVVPQDVWD LKLFKETPSK SVLYFITCYF SHKGSQGDLR
DCLQLRKNLL TAVLGYLNLK ESLILNEHLV LLLPAAVYAL CAGCAPSTHC YKVLLSSHAF
IYNLVAADDC AKTDENEHER LYEFFECSLD ILAKVGLDSQ VEIVPFRCNQ SLRLPSQLRD
PLLHEVETHI LGALADKQAE KRTVSDINFI CALLSNFIHG SLVTRKRDEM LTFVSKMGQY
LLELLDHAVN VIKETGCDFQ SLGCMGSGLD CIARSCLLAS FRSLVSCPIF SRRGDENVMD
TVLYGAIVQS MERLLTELAK LYEQFSERIR NPYSETMLSD SSDTSLQISS LLDSSRSRIV
DMELDVNEDS KDVDILNFGG KITIDTSFSM VKWKLGMVSL ISSFFSVLDF VTWDVLFELL
GKEGETKVCE NVLYLLCQHP HWSSAAKIMD LVKSMFDMVE TRVIVKLDCA SILVSTCQLL
CTLLSLGAVG KNGDSLIHLG DLVSRVAEFG LLDWMGRVKL IDCICDFVLL SPQIGQTMVQ
RLFLLLQDPD YRVRFSLAQR IGVLFETWDG HDELFQDICS NFGVVMVFHS KGRLVTAKEV
LAAGPQPRPT METIIFTLMH VALHSEKIEL EAIFMMCVVA AIDPCHRDLV IAVVDNLSRQ
LQYATRFKYL EELIGTILFF WVACGVSLVA LVEIRQLFVP DAEPSYFMQY CCRWLLPALI
LHEDISNLNL VARIACQPST VLVKNHFVQI FSVCMALHCS KRLDSDKGAL VLQSSILHLS
EISENERDKL IKRHMVSIVS HILSLTSCAS DPAVPFFSRE TVARAVQTVV DGFLETEDYP
TSVAVLDKIK IFRPDRVFMF IVEMHYKIAG AVHHRHRCHK LAGIEVLIDI LGHRAAVSST
SNYLLSLIGL LIDCKDLQDQ CFRVISALLK TFKSNPSKEV VRVLGEQFQF LVSKLVEIAS
DTVGELSGTT SSQVMSLLLQ LIVECDPSLH DYIKELEPFP ETDIFDKVRA FHQELCQAYS
PRDHLLKFVK RSCYLPPRLL LCSVQAMHKK LLMREYFELE RNKRDTVVDI NWHSDSEIVS
AVWTLVRMCS SDDSNCIRTL MSDFISRVGI GDPHCVVFHL PGESGDINVC KLTADDSPTD
ISFSVDTAIT EKLLIMLLNL LKKYLMDDSV RIVDLASQAL RGILSTERGQ RAILSFDSYE
RSLIEIHSKG VNAELVENFL LDLEKRFRAE AIPLEEPTLW ETQNKTFETW ICPLVHSLIG
YNNDVILRLC QDIVLLKAEV AEFLLPSVIE DLAGRKNMDV DLHKLISLQV QEHILTDSNK
LIKSIQVFLN ALNKLRLCYV FERSSIPSKR ESLKYAKPSS YGSKSRSTSG KARDYMATSS
AMSMLTSSWD KVYWLSIDYL LVAKSAVICG SYFTAMMYVE YWCEEHFSSL TLGRPDLAHI
EVLPDHIEVL VSAVTQINEP DSLYGIIRSH KLTSQVVTFE HEGNWSKALE YYDLQVRANA
MLETNGGSRT FFVDHTQPAA HIFVPESKDE MKLRKPYKGL IKSLQKIGCT HVLESYCQGL
TSRKGQLQQD LEFTELQYEA AWRAGNWDFS LLVHGGSSSS GQNVKSDRFN ENLYSCLRAL
KEGDFDEINR KLKDSKQELV WSVSCSSEES TEYIYSTIIK LQIDRDNFLS LALEGYKHCL
ILGDKYDVRV VFRLVSLWFS LSSTQNIINN MLNTINEVQS YKFVPLVYQI ASRMGSSKDG
VGPHNFQFAL ISLVKKMAVD HPYHTIFQLL ALANGDRIKD KQRSRNSFVV DTDKIISARA
LLDELSSYHG PVIGQMRRMV EIYIKLAELE TRREDTNKRV ALPREIRSVR QLELVPVVTS
SFPVDRSCTY HDGSFPYFKG LADSIMIMNG INAPKVVECL GSDGKRYRQL AKSGNDDLRQ
DAVMEQFFGL VNTFLKNNRD TWKRRLGVRT YKVIPFTPSA GVLEWVNGTL PLGEYLIGST
RNGGAHGRYG IGDWSFPKCR EHMSNEKDKR KAFQEICENF RPVMHHFFLE RFLQPADWFE
KRLAYTRSVA ASSMVGYIVG LGDRHAMNIL IDQTTAEVVH IDLGVAFEQG LMLKTPERVP
FRLTRDIIDG MGVAGVEGVF RRCCEETLAV MRTNKEALLT IVEVFIHDPL YKWALSPLKA
LQRQKDLDDD LETCLEDSQD QYEGNKDAAR ALMRVKQKLD GYEEGELRSI NGQVQQLIQD
AIDPERLCQM FPGWGAWM
//
