ID A0A2C9W4Z5_MANES Unreviewed; 496 AA.
AC A0A2C9W4Z5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=fumarate hydratase {ECO:0000256|ARBA:ARBA00012921};
DE EC=4.2.1.2 {ECO:0000256|ARBA:ARBA00012921};
GN ORFNames=MANES_03G058700 {ECO:0000313|EMBL:OAY54233.1};
OS Manihot esculenta (Cassava) (Jatropha manihot).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae;
OC Manihot.
OX NCBI_TaxID=3983 {ECO:0000313|EMBL:OAY54233.1, ECO:0000313|Proteomes:UP000091857};
RN [1] {ECO:0000313|EMBL:OAY54233.1, ECO:0000313|Proteomes:UP000091857}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AM560-2 {ECO:0000313|Proteomes:UP000091857};
RC TISSUE=Leaf {ECO:0000313|EMBL:OAY54233.1};
RA Bredeson J.V., Prochnik S.E., Lyons J.B., Schmutz J., Grimwood J.,
RA Vrebalov J., Bart R.S., Amuge T., Ferguson M.E., Green R., Putnam N.,
RA Stites J., Rounsley S., Rokhsar D.S.;
RT "WGS assembly of Manihot esculenta.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class-II fumarase/aspartase family. Fumarase
CC subfamily. {ECO:0000256|ARBA:ARBA00009084}.
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DR EMBL; CM004389; OAY54233.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2C9W4Z5; -.
DR STRING; 3983.A0A2C9W4Z5; -.
DR EnsemblPlants; OAY54233; OAY54233; MANES_03G058700.
DR Gramene; OAY54233; OAY54233; MANES_03G058700.
DR OMA; AKWRAQT; -.
DR OrthoDB; 1341425at2759; -.
DR Proteomes; UP000091857; Chromosome lg3.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0045239; C:tricarboxylic acid cycle enzyme complex; IEA:InterPro.
DR GO; GO:0004333; F:fumarate hydratase activity; IBA:GO_Central.
DR GO; GO:0006106; P:fumarate metabolic process; IBA:GO_Central.
DR GO; GO:0006108; P:malate metabolic process; IBA:GO_Central.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IBA:GO_Central.
DR CDD; cd01362; Fumarase_classII; 1.
DR Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR HAMAP; MF_00743; FumaraseC; 1.
DR InterPro; IPR005677; Fum_hydII.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR018951; Fumarase_C_C.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR NCBIfam; TIGR00979; fumC_II; 1.
DR PANTHER; PTHR11444; ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE; 1.
DR PANTHER; PTHR11444:SF1; FUMARATE HYDRATASE, MITOCHONDRIAL; 1.
DR Pfam; PF10415; FumaraseC_C; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000091857}.
FT DOMAIN 43..373
FT /note="Fumarate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00206"
FT DOMAIN 439..491
FT /note="Fumarase C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF10415"
SQ SEQUENCE 496 AA; 53633 MW; F42BB9451EB8CC50 CRC64;
MAMGVVVRRL SRGSTTSQTV VSLSHASWRL YSTAFREERD TFGPIQVPAD KLWGAQTQRS
LQNFEIGGDR EQMPEPIIRA FGILKKCAAK VNMDYGLDPS IGKAIMQAAQ EVAEGKLNDH
FPLVVWQTGS GTQSNMNANE VIANRAAEIL GHKRGEKFVH PNDHVNRSQS SNDTFPTVMH
IAAATEINSR LIPNLRNLHT ALHSKSTEFK DIVKIGRTHT QDATPLTLGQ EFSGYTTQVK
YGIDRILCTL PRMYQLAQGG TAVGTGLNTK KGFDVKIAAA VAEETRLPFV TAENKFEALA
AHDAFVESSG ALNTIATSLM KIANDIRLLG SGPRCGLGEL VLPENEPGSS IMPGKVNPTQ
CEALTMVCAQ VMGNHVAITV GGSNGHFELN VFKPMIASNL LHSVRLLGDA SASFEKNCVR
GIQANRERIS KLLHESLMLV TSLNPKIGYD NAAAVAKLAH KEGSTLKEAA LKLQVLTSEE
FDSLVVPEKM IGPSNG
//
