ID A0A2C9WBQ0_MANES Unreviewed; 5109 AA.
AC A0A2C9WBQ0;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=UBR-type domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=MANES_02G059900 {ECO:0000313|EMBL:OAY56966.1};
OS Manihot esculenta (Cassava) (Jatropha manihot).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae;
OC Manihot.
OX NCBI_TaxID=3983 {ECO:0000313|EMBL:OAY56966.1, ECO:0000313|Proteomes:UP000091857};
RN [1] {ECO:0000313|EMBL:OAY56966.1, ECO:0000313|Proteomes:UP000091857}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AM560-2 {ECO:0000313|Proteomes:UP000091857};
RC TISSUE=Leaf {ECO:0000313|EMBL:OAY56966.1};
RA Bredeson J.V., Prochnik S.E., Lyons J.B., Schmutz J., Grimwood J.,
RA Vrebalov J., Bart R.S., Amuge T., Ferguson M.E., Green R., Putnam N.,
RA Stites J., Rounsley S., Rokhsar D.S.;
RT "WGS assembly of Manihot esculenta.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the UBR4 family.
CC {ECO:0000256|ARBA:ARBA00009970}.
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DR EMBL; CM004388; OAY56966.1; -; Genomic_DNA.
DR STRING; 3983.A0A2C9WBQ0; -.
DR EnsemblPlants; OAY56966; OAY56966; MANES_02G059900.
DR Gramene; OAY56966; OAY56966; MANES_02G059900.
DR OrthoDB; 10597at2759; -.
DR Proteomes; UP000091857; Chromosome lg2.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0009926; P:auxin polar transport; IBA:GO_Central.
DR GO; GO:0048281; P:inflorescence morphogenesis; IEA:EnsemblPlants.
DR GO; GO:0010311; P:lateral root formation; IEA:EnsemblPlants.
DR GO; GO:0009640; P:photomorphogenesis; IEA:EnsemblPlants.
DR GO; GO:0009733; P:response to auxin; IEA:EnsemblPlants.
DR GO; GO:0009620; P:response to fungus; IEA:EnsemblPlants.
DR GO; GO:0009826; P:unidimensional cell growth; IEA:EnsemblPlants.
DR CDD; cd19681; UBR-box_BIG_like; 1.
DR CDD; cd02249; ZZ; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR025704; E3_Ub_ligase_UBR4_C.
DR InterPro; IPR045189; UBR4-like.
DR InterPro; IPR003126; Znf_UBR.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR21725; E3 UBIQUITIN-PROTEIN LIGASE UBR4; 1.
DR PANTHER; PTHR21725:SF1; E3 UBIQUITIN-PROTEIN LIGASE UBR4; 1.
DR Pfam; PF13764; E3_UbLigase_R4; 1.
DR Pfam; PF00569; ZZ; 1.
DR SMART; SM00396; ZnF_UBR1; 1.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101908; Putative isomerase YbhE; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51157; ZF_UBR; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000091857};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 1577..1648
FT /note="UBR-type"
FT /evidence="ECO:0000259|PROSITE:PS51157"
FT DOMAIN 2611..2670
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT ZN_FING 1577..1648
FT /note="UBR-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00508"
FT REGION 1536..1569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1675..1695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3147..3173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3818..3871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1541..1564
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3159..3173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3835..3863
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5109 AA; 569412 MW; A57C37C23C6D295B CRC64;
MADHLTKLYH SLFEEKLPPT DLFLRIRSDN SIKQALHHIY IILKRALSTI EPADAGHATT
SNKEIKLGYQ SWTNLQIQSL IALGLVIVSA SRSLSVEQAE PMVIAVVQQL LEFAVCYLER
SDFSTDDLSI QGNVLLLMEL ALVDGIDKAS DPSHSCSINS LLELLPMDSG DCCNTELESY
IKCSLQEGVS CSMGEKPVDQ LLMTLAYDCV QPEWQAIGFS GSKQDLNSLI FLCQHWAFVH
MGCARRLILC FKDLVDLPYV YHEKSAGPEF CRRLSFGLRI LKLVRNLMKD IPNVGYDASL
LQEVALCADL LPRLFKISCE FANNQAVVEG SSDCLVLLLL EEFLLLVQVV FCNSCAFQNI
QVCIVASLLD NLDSSIWRYN KSAANPKPPL VYFPRSVLHI LKLIKDLRRQ TYQALDLKGF
DTVLIGSSTD MKNNYPLCHA HSEKVPLLKK FNIEDLWKII FAPSTQWMDN LMHLIFFLYC
EGVKLRPKVE RSHSSSLRTN CPSEVENVVC HDDEALFGNL FSEGGRSLGS TDGYDQPPVT
VNSCSGNGNM PMQAASELLS FLKECVFSHD WSPFLFEDGR KRLRENHIDI LLSILISQGR
CSEDKSADRC AVSLEEKKIG HIYEICFELL QNLLTCHALS GTLEEYLVEK ILNVENGAFV
YNDQTLTLLS HTLCSRKGLA GSQLRTRLYE GFVGFIVDKS KAVCLKCPSI KEFIGTLPSV
FHIEILLMAF HLSLEREKAT LANLIFSSLQ RIDAPSAGFC ATQLSCWALI VSRLILLLRH
MMFYPHTCPT SLLLDFRSKL REVPGCTPVL PNIINDQASS WASIAVKVVL SEWVEADPSI
SALANQLIDV SAVPPLLCRD ELAIESLCLS WKDISATFSQ ILGFWKGRRA AAVEDLIVER
YMFLLCVDIP IMSSRSNKLL LWSETQSIDI SNMMFFFHFS HSLIANCDDI GKSMELPDVV
IGVLQHLCAL HMSADVKELG WDFLRVGFWS SLVLSLLNVG ISQYSIKNGV PGVSPFWIEN
TARDNLYVTV AEGLTSCLIE AGQVPLLLRM LSSLLNRYLQ VYQEAFLTTH DDGECNAIRL
SSLLLLKHSG LEKSLQDEFL KKSDINSYHL ESYSDLFSKW DAIVDKRAPT VRCKVLWECM
MHGFPSHLQT PSAILLSCIL SIRGIIFVLD RLFGLENLRE SICKERAVLC QILSSVMIIK
FDRIFESIRG KCEAIVRNLS SGSELSDYSD LFLMKHMEGF LREINARDEH DSSTLEWVIT
KIINTADSLR KDPLKSAIFK FYLGVEDASE TVEEFYGLQR GDLLVLLDSL DNCASESVNG
KVLSFFVDLL LGDFFPNLKQ KVEKKFFEMD VRSLSTWLEK RLLGCVLEAS DGAGCAKGNS
VFLRETTMNF ILSLVSSPSE LHATELNRHL FEAVLASLDT AFLLFDVHVA KSYFQFVVQL
SRGEYLMKLL LTRTVVLMEK LAVDDRLLPG LKFLFGFFGN VLSDSETCKK TLEKKSGKSL
SGSNLGTVSV VLKPIGSRKN SDSVVLSASQ EGGSAAVECD ATSVDEDEDD GTSDGEVASI
DKDDEEDTNS ERTLASKVCT FTSSGSNFME QHWYFCYTCD LTVSKGCCSV CAKVCHRGHR
VVYSRSSRFF CDCGAGGVRG SNCQCLKPRK FTGSESAPIR SASNFQSFLP FSEDADQLPE
SDSDLDEDLS SDTDNSLRLS IPRELQDGVT ALLQELDVES RILQLCSSLM PSITSKRGSN
LSKDKKIVLG KNKVLSYGAD LLHLKKAYKG GSLDLKIKAD YPNAKELRSH LASGSLVKSL
LSVSSRGRLA VGEGDKVAIF DVGQLIGQAT IAPVTADKTN IKPLSRNVVR FEIVHLTFNS
VVENYLAVAG YEDCQVLTLN PRGEVTDRLA IELALQGAYI RQISWVPGSQ VKLMVVTNRF
IKIYDLSQDN ISPLHYITMP DDIIVDATLL MASQGRMFLV VLSEQGSLFR LELSVEGNVG
ATPLKEIINI QDREINAKGS SLYYSSTYKL LFISYQDGTT LMGQLSLDAT YLTEMSFVYE
DEQDGNMRPA GLHRWRELLM GSGLFVCFSS VKSNAALAVS MGLDELHAQS MRHAVSSTSH
LVGLTAYKPL SKDKIHCLVL HDDGSLQIYS HIPSGSDGGA SLTAEKVKKL GSGILNNKAY
AGVKPEFPLD FFEKTVCITA DVKLGGDAIR NSDSEAAKHS LASEDGFLES PSPAGFKISV
SNSNPDIVMV GFRVHVGNTS ANHIPSDITI FQRVIKLDEG MRSWYDIPFT VAESLLADEE
FVITIGPTFN GTTLPRIDSL EVYGRAKDEF GWKEKMDAVL DIEARVLGSN SLLGGAGKKC
RSVQSAPIQE QVVADGLKLL SRLYSLSRSQ EDDSKMEPSE LKCKLLLETI FESDREPLLQ
AAACRVLQSV FPKKERYYQV KDTMRLHGVV KSTSMLSSRL GAGENTGGWM VEEFTAQMRA
VSKIALHRRS NLALFLETNG SEVVDGLMQV LWGILEFEQP DTQTMNNIVV SSVELIYCYA
ECLALHGKDT MGPSVAPAVV LLKKLLFSPN ESVQTSSSLA ISSRLLQVPF PKQTMLATDD
AVDSAVSASG SAEATGGNTQ VMIEEDSITS SVQYCCDGCS TVPILRRRWH CTVCPDFDLC
EACYQVLDAD RLPPPHSRDH PMTAIPIEVE PLGGEGNEIH FSTDDANDSN LMPISADVSV
QNSTPSIHVL EANESGEFSA SVADAVSISA SKRAVNSLLL SELLEQLKGW MQTTSGVHAI
PVMQLFYRLS SAVGGPFIDS YKPEALDLEK LIRWFLDEID LKKPFVAKTR SSFGEVAILV
FMFFTLMLRN WHQPGSDGSI PKSSGNTELH DKNVIQVSSV ASQSSMDGQE KNDFTSQLLR
ACNTLRNQAF VNYLMDILQQ LVNVFKSPNA NFDTTHGLNA GFGCGALLTV RRDLPAGNFS
PFFSDSYAKA HRVDIFTDYH RLLLENVFRL AYTLVRPEKQ DKTGEKDKVY KISSGKDLKL
DGYQDVLCSY INNPHTTFVR RYARRLFLHL CGSKTHYYSV RDSWQFSTEM KKLWKHTNKS
GGPQNPVPYE RSVKIVKCLS TMAEVATARP RNWQKYCSRH GDVLPFLMNA VFYFGEESVI
QTLKLLNLAF YSGKDITHSL QKFEAVDSGT SSNKSGAQSL DSKKKKKGEV GMGTESGLEK
SYLDMESAVD IFTDKGGDIL RQFVDCFLLE WNSSSVRTEA KCVLYGAWHH GKHSFKETML
MTFLQKVKNL PMYGQNIVEF SELVTWLLGK VPDASSKQQT ADLVDRCLTP DVIRCIFETL
HTQNELIANH PNSRIYNTLS GLVEFDGYYL ESEPCVACSS PEVPYSKMKL ESLKSETKFT
DNRIIVKCTG SYTIQTVTMN VHDARKSKSV KVLNLYYNNR PVADLSELKN NWSLWKRAKS
CHLVFNQTEL KVEFPIPITA CNFMIELDSF YENLQALSLE PLQCPRCSRP VTDKHGICSN
CHENAYQCRQ CRNINYENLD SFLCNECGYS KYGRFEFNFM AKPSFTFDNM ENDDDMKRGL
AAIESESENA HRRYQQLLGF KKPLLKIVSS IGENEMDSQQ KDSIQQMMVS LPGPSCKINR
KIALLGVLYG EKCKAAFDSV SKSVQTLQGL RRVLMSYLHQ KHSDDSIAAS RFVVSRSPNN
CYGCATTFVT QCLEMLQVLS KHPNSKKQLV AAGILSELFE NNIHQGPKTT RVQARAVLCA
LSEGDINAIT ELNSLIQKKV MYCLEHHRSM DIALATREEL LLLSEVCSLA DEFWESRLRV
VFQLLFSSIK LGAKHPAIAE HVILPCLRII SQACTPPKPD TVDKEQGVGK SASAAQLKDE
NNSNTSGPLG GVVSGNKSAQ EPSEKNWDAS HKTQDIQLLS YSEWEKGASY LDFVRRQYKV
SQAVKGAGQR SRTQRHEYLA LKYALRWRRR ACKTSKGDLS TFELGSWVTE LVLSACSQSI
RSEMCMLISL LCAQSSSRRF RLLNLLMALL PATLAAGESA AEYFELLFKM IDSEDARLFL
TVRGCLTTIC KLITQEVVSV ESFERSLHID ISQGFILHKL IELLGKFLEV PNIRSRFMRD
NLLSDILEAL IVIRGLVVQK TKLISDCNRL LNDLLESLLL ESSENKRQFI RACICGLQIH
GEERKGRTCL FILEQLCNLI CPSKPESVYL LVLNKAHTQE EFIRGSMTKN PYSSAEIGPL
MRDVKNKICH QLDLLGLLED DYGMELLIAG NIISLDLSVA QVYEQVWKKS NGQASSAMAN
STLLSSSGMT SARDCPPMTV TYRLQGLDGE ATEPMIKELE EDREESQDPE VEFAIAGAVR
EFGGFEILLG MIQRLRDDFK SNQEQLVAVL NLLMHCCKIR ENRRALLNLG ALGLLLETAR
RAFSVDAMEP AEGILLIVES LTLEANESHN ISITQSALTV TNEETGTGEQ AKKIVLMFLE
RLCHPSGLKK SNKQQRNTEM VARILPYLTY GEPAAMEALI QHFNPYLQNW RDFDQLQKQH
QDNQRDDNIA QKAAEQRFTV ENFVRVSESL KTSSCGERLK DIILEKGIID VAIKHLRESF
AVAGQAGSKS SAEWSSGLKL PSVPHILSML RGLSMGHFAT QVCIDEGGIL PLLHALEGVS
GENEIGARAE NLLDTLSNKE GKGDGFLEEK VRKLRHATRD EMRRRALRRR EELLQGLGMR
QERERIVVAQ PILEGLEDVE EEEDGLACMV CREGYSLRPT DLLGVYSYSK RVNLGVGTSG
SARGECVYTT VSYFNIIHFQ CHQEAKRADA ALRNPKKEWE GATLRNNESL CNSLFPVRGP
SVPLAQYNRY VEQYWDNLNA LGRADGSRLR LLSYDIVLML ARFATGASFS AESRGGGRES
NSRFLPFMIQ MARHLLEGSS SQRHSMAKAV SSYISSSYLD SRSAPGAQPA PGTEETVQFM
MVNSLLSESY ESWLQHRSSF LQRGIYHAYM QHTHGRSTAR ASSTSTGMVR MESASISPMT
EMADADELLP IIRPMLVYTG LIEQLQRFFK FKKSPHMPTI RAEGTSTGSE GEDESGSLEG
WEVVMKERLL NVREMVGFSK ELLSWLDEMS SATDLQEAFD IIGVLADVLA NGISRCEDFV
HAAVNAGKS
//
