ID A0A2C9ZKA9_9ACTN Unreviewed; 604 AA.
AC A0A2C9ZKA9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Reductase {ECO:0000313|EMBL:OUC83463.1};
DE Flags: Fragment;
GN ORFNames=CA983_42485 {ECO:0000313|EMBL:OUC83463.1};
OS Streptomyces swartbergensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=487165 {ECO:0000313|EMBL:OUC83463.1, ECO:0000313|Proteomes:UP000195105};
RN [1] {ECO:0000313|EMBL:OUC83463.1, ECO:0000313|Proteomes:UP000195105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HMC13 {ECO:0000313|EMBL:OUC83463.1};
RA Le Roes-Hill M., Prins A., Durrell K.A.;
RT "Biotechnological potential of actinobacteria isolated from South African
RT environments.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUC83463.1}.
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DR EMBL; NGFN01000601; OUC83463.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2C9ZKA9; -.
DR Proteomes; UP000195105; Unassembled WGS sequence.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd06199; SiR; 1.
DR Gene3D; 3.40.50.360; -; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR003097; CysJ-like_FAD-binding.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR001094; Flavdoxin-like.
DR InterPro; IPR008254; Flavodoxin/NO_synth.
DR InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR19384:SF128; NADPH OXIDOREDUCTASE A; 1.
DR PANTHER; PTHR19384; NITRIC OXIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00667; FAD_binding_1; 1.
DR Pfam; PF00258; Flavodoxin_1; 1.
DR Pfam; PF00175; NAD_binding_1; 1.
DR PRINTS; PR00369; FLAVODOXIN.
DR PRINTS; PR00371; FPNCR.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF52218; Flavoproteins; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS51384; FAD_FR; 1.
DR PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023192};
KW Cysteine biosynthesis {ECO:0000256|ARBA:ARBA00023192};
KW Electron transport {ECO:0000256|ARBA:ARBA00022982};
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW FMN {ECO:0000256|ARBA:ARBA00022643}; NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Transport {ECO:0000256|ARBA:ARBA00022982}.
FT DOMAIN 69..207
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 235..453
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
FT REGION 213..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:OUC83463.1"
SQ SEQUENCE 604 AA; 65429 MW; C8447729D691E8F0 CRC64;
PPVLSAQERQ YLTGFLAGLG SGAPGVPVLP PDAPFSPEHA LWVNGVLAGM YSRSTPPAAP
AREPSGREVV VLWASQTGNA EEFATATAER LTATGHRTTL VGMDEADVAA LARTADLLFI
TSTFGDGDAP DNGTGLWDTL AGERAPRLDG VRYAVLAFGD SSYDDFCGHG RRLDARLDEL
GGVRLAPRTD CEPDYEPSAG EWLDHVLSAL AGPATAPADS PASRPEPKPK PKPKPAAAVA
RLVGNRLLSR PGAGKEVRRF TFDTSGTDLA YEAGDALGVR PVNAPDLVAE WLAVTGLDGG
TAVEVAGAGE MPFAEALARH LDITRITPDL LRFVAERARD KHELRRLLRP DNKDGLAQWC
WGRQAVDVIA EYAVRAGAEE WAGVLRMLQP RLYSISSSPL VDPRQVSLTV SVVRYENLHG
RQRGGVCSPF LADAAADTEV PVFVQRSPHF RPPADASTPM VMVGPGTGVA PFIGFLQERR
ALGHKAPNWL FFGEQHRATD FYYEEELTAL LDEGTLTRLD TAFSRDQRNK VYVQDRMREH
GPELWHWLQD GARFYVCGDA SRMAKDVDRA LRDVAVAHGG LSEAEAAAYV KQLAAEKRYV
RDVY
//
