ID A0A2D0HBZ2_9NOSO Unreviewed; 772 AA.
AC A0A2D0HBZ2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN Name=pbpC {ECO:0000313|EMBL:PHM07045.1};
GN ORFNames=CK516_29545 {ECO:0000313|EMBL:PHM07045.1};
OS Nostoc sp. 'Peltigera malacea cyanobiont' DB3992.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae; Nostoc.
OX NCBI_TaxID=1206980 {ECO:0000313|EMBL:PHM07045.1, ECO:0000313|Proteomes:UP000223928};
RN [1] {ECO:0000313|EMBL:PHM07045.1, ECO:0000313|Proteomes:UP000223928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DB3992 {ECO:0000313|EMBL:PHM07045.1};
RA Gagunashvili A.N., Andresson O.S.;
RT "Distinctive characters of Nostoc genomes in cyanolichens.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHM07045.1}.
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DR EMBL; NSHF01000387; PHM07045.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2D0HBZ2; -.
DR Proteomes; UP000223928; Unassembled WGS sequence.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR011815; PBP_1c.
DR InterPro; IPR009647; PBP_C.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; TIGR02073; PBP_1c; 1.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF15; PENICILLIN-BINDING PROTEIN 1C; 1.
DR Pfam; PF06832; BiPBP_C; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000223928}.
FT DOMAIN 60..232
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 325..597
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT DOMAIN 667..752
FT /note="Penicillin-binding C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06832"
SQ SEQUENCE 772 AA; 86191 MW; C60CD2D9C1A95730 CRC64;
MKLILRSLLK LKRTSKVILA VLLICLVVRL LPYFAPIRAA DIAQNHLAMQ FSDRNGLPLG
TLLTRDQEHT SVVPLNQVSP HFIHAILAAE DGSFYHHGAL DMKAIIRASK EAIHAKRIVS
GASTITMQLA RMLDPVPRSF SGKLSEIWLS WRLTAGMNKD EILSAYINRL PMGGNIYGVE
AAAQIYFSIP ASELNLAQAS LLAAIPNNPT YFNPYEHWER LKQRQKYVLN RMVQEKYING
AMATPTSATN ATRTQTEKVV FQSRQRGIIA APHFLFWLAN QFDKRQTEQN SPIRTTINRP
LQQFVEAQVQ QVISSLAANN VHDAAALVID NQTGEVLAYV GSPDYFNEAK LGRNDGVQAL
RQPGSTLKPF VYELALEKGL IRPNTILADV PARYAIPGAK LYSPTDYTER FLGPVRVRIA
LANSLNVPAI KVLEKVGVET FLKRLHQLGF EHLNQTPEHY GLGLTLGSGE VSLWELARAY
LTIARQGDAT PIVSTFSNSP IQNPKYTIQN STTIWQLITN ILSDSYARAT AFGVDSVLNL
PFPVAVKTGT SSNFRDTWTV GFTTDYTVAT WVGNFNGEPM RQVSGVTGAA PLWNRIMLHL
HEHQEPTGFP SPEGLVQLPV CAISGLRPTP DCTSVVQEYF YPEDKSNYER DNQFNLPPEY
DEWLAKQQQS NFTSANLRIL SPHHGDLFLL YPGEKAKQKL EFKLAGNKSA PVEWWLNGEK
LDTNSANSLF WNLRPGKWTL EARSGEMSDK VSFQVELANI KPTRRGFSIS NN
//
