ID A0A2D0HE26_9NOSO Unreviewed; 1104 AA.
AC A0A2D0HE26;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Hydrophobe/amphiphile efflux-1 family RND transporter {ECO:0000313|EMBL:PHM07758.1};
GN ORFNames=CK516_24965 {ECO:0000313|EMBL:PHM07758.1};
OS Nostoc sp. 'Peltigera malacea cyanobiont' DB3992.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae; Nostoc.
OX NCBI_TaxID=1206980 {ECO:0000313|EMBL:PHM07758.1, ECO:0000313|Proteomes:UP000223928};
RN [1] {ECO:0000313|EMBL:PHM07758.1, ECO:0000313|Proteomes:UP000223928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DB3992 {ECO:0000313|EMBL:PHM07758.1};
RA Gagunashvili A.N., Andresson O.S.;
RT "Distinctive characters of Nostoc genomes in cyanolichens.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHM07758.1}.
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DR EMBL; NSHF01000280; PHM07758.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2D0HE26; -.
DR Proteomes; UP000223928; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF78; CATION OR DRUG EFFLUX SYSTEM PROTEIN; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000223928};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 358..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 414..435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 455..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 555..574
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 886..906
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 912..932
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 999..1019
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1031..1053
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1063..1104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1084..1104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1104 AA; 119101 MW; 93079A813074F463 CRC64;
MFVNTFIRRP VLTTVCTFII LLLGSICIPI LPISQLPDLA PVQITVSSNN IGADAQTTEN
TVTNIIERQI NGVKDVSYIS SNTGNDGSSN ITVSFPTNVN SDIAQVNVQN KEALASPQLP
DTIQRTGVTV ETASSSLLLV YGFYSENNEY DNIFISNYVD LYIFDQIKRL PGVGSARVFG
ERKYAMRLWL DPNKLAQHQL TPQDVTAALQ QQNIQVGAGA IGKEPAPDNQ SFEFALRATS
RFKDAAEFED MVLKVSPTGT NSTTNSPTSS ILVKVRDVGR VELGAENYLA DAKFTIPGNA
PKAAVGLGIY QLPGSNALKV AHAVEEQIKI LEKNFPPGLK AQLAFDTTPF VEISLEEVLH
TLVEAIVLVV LVIFVFLQDW RTTIIPTVAI PVSLIGTCAA LLVLGFQINT LTLFGFVLAI
GIVVDDAIIV VEAVAVKLEQ GMRPFEAAVE AMKELTGAII ATSLVLMAVF IPVAFIPGTT
GIVYKQFALT VACSIGISTF NALTFSPSMA AILMRPAQTP RGPLGWFFTQ FNRGFSWFTR
RYVGFVSYLT HVKPIVIGVF VTGLLATVLM YRAVPTGFIP EEDQGYFFVI VQGPDGVSLK
YTESVMNKVV KEVTSAPEVR ASFMISGFGF DGNASNLGIA FANLKPWKER TEESQSVYGI
LQRLNKKLST ITEARAIAVN APPVRGLSTT GGFEFIIQDK TGSAPIETLI EAAQKVIGAA
RTNPALQGVF TQFTADTPQF DIQVNRNQAK ALNVEINDIF GALQTYLGSQ YVNNFVQGQR
QYRVYVQADG VFRSNPDDIG KLYVRSASGA MIPLSSLVKI TPFVGPKTIA HYNLYRSIKV
QGAPAPGASS GQAIKAMEQL AAENLPQGFG YEWTGTYLQE KTSGGATGLI FGLAIVIVFL
VLAAQYESYI DPIIILLTVP LAVLGAMTAI WLRSNIFMAG SLFPKVVDDI YCQVGLVTLI
GLAAKNAILV VEFANQLHEQ GMSYTRAAVK AGQERLRPIL MTSFAALLGF LPLVISQGAG
ASSRWSLGTA LFGGLMLSTF LSLFLVPILY ILVKSLAQAI LPRKRGGSNP PDSPNGASGT
RHEVLPAGSS QPETQLRSQE DGIT
//
