ID A0A2D0KC92_9GAMM Unreviewed; 3460 AA.
AC A0A2D0KC92;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Amino acid adenylation {ECO:0000313|EMBL:PHM60827.1};
GN ORFNames=Xsto_03620 {ECO:0000313|EMBL:PHM60827.1};
OS Xenorhabdus stockiae.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Xenorhabdus.
OX NCBI_TaxID=351614 {ECO:0000313|EMBL:PHM60827.1, ECO:0000313|Proteomes:UP000222366};
RN [1] {ECO:0000313|EMBL:PHM60827.1, ECO:0000313|Proteomes:UP000222366}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17904 {ECO:0000313|EMBL:PHM60827.1,
RC ECO:0000313|Proteomes:UP000222366};
RX PubMed=28993611; DOI=10.1038/s41564-017-0039-9;
RA Tobias N.J., Wolff H., Djahanschiri B., Grundmann F., Kronenwerth M.,
RA Shi Y.M., Simonyi S., Grun P., Shapiro-Ilan D., Pidot S.J., Stinear T.P.,
RA Ebersberger I., Bode H.B.;
RT "Natural product diversity associated with the nematode symbionts
RT Photorhabdus and Xenorhabdus.";
RL Nat. Microbiol. 2:1676-1685(2017).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHM60827.1}.
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DR EMBL; NJAJ01000046; PHM60827.1; -; Genomic_DNA.
DR Proteomes; UP000222366; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd17643; A_NRPS_Cytc1-like; 2.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd19544; E-C_NRPS; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 4.
DR Gene3D; 3.40.50.980; -; 6.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF00550; PP-binding; 3.
DR Pfam; PF00975; Thioesterase; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 931..1005
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2015..2089
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3108..3182
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 3460 AA; 386003 MW; 396642E82FF0FD9C CRC64;
MYKYQDYLCI HHLFEEQVAF NPEATALCFE NVALSYGELN VKANRLAHQL MDLGVGPDQL
VAICVERSPA MVVGLLAILK AGGAYVPLDP VYSSERLAYI LADTVPTLVL ADVTGQQVLG
EVLQAYTVLD PNEIRLKNGV EADINPKIPS LTPSNLAYVI YTSGSTGQPK GVMVEHAQIV
RLFDTTHSAY HFKSSDVWCL FHSFAFDFSV WELWGALRYG GRLILVSHPV TRSPQAFYQL
ICEQGVTILN QTPSAFNALM EYVKPSSDQL RYIIFGGEAL QLSTLRDWYA VHDEFMPQLV
NMYGITEITV HATYCPLSSS SIQQAESLIG KRLPDLHLYL LDIHGQPVPM GTVGEIYIGG
AGVARGYLNR PELTAERFLP DPFAGTPDAR MYKSGDLARY LPDGNLVFFG RNDEQVKIRG
FRIEPGEIAA RLTEHQSVRE AVVVAQGSDI DKRLVAYIVT HEHQQERDIK RELNQVDEWQ
TIYNLEYSGS QDIHIPFGED FCGWISSYNG QPLPLDQMQE WRAETVARIL SLKPKHMLEI
GVGSGLLLSQ IALHCQTYWG TDLSNEVIDK LQKQIAELPE FCEHVTLLCQ PAHQVEGLPT
DYFDTIVLNS VAQYFPSADY FIEMIRHSLD LLAPGGVIFL GDIRSLPLLR SFATAIQLAK
NNNISNIDLL NWEIERHLRA EKELLFDPSF FVALQKMFND IAGVDIRLKR GMFSNEMNRY
RYDVLLRKKP STVISLAKLS ELRWIDEINN LDSLKAYLIA HNVRRLRICN IPNAHLIDEV
IALNKLHQNK SYAAVTEILP PDRSPPHPED FHILGVNLGY QVIATWSGKG NPGEIDILFL
EQECDTLTDT YRSPNIVEDI FQLTNTPIHQ DDSRHLVMEL KIKLSSQLPD YMVPSAFVRM
NSLPLTPNGK LDLRALPIPQ DGAFVQTVYE APKGDIEVLL AGIWSELLGV EKIGRYDNFF
ALGGHSLMAV RLASRIVSIG AELPLTILFS SLTLKDLALV IGAHCNTSAL AQTSIYAISR
DEPLPLSFSQ QRLWFLAQLN EEISKAYHIP LAVRLRGQLN IAALQQALDT LWGRHETLRS
VFVNIEDEPK VRLLAANQGL PLRQLGQYDD SNKGTDTLTD LARFCADEAL APFNLASGPL
IRACLIQVGT AKSTNSSADE YVFMLTQHHI VSDGWSLGVL LPELSVLYTA YNSHKDNPLP
PLTIQYPDYA AWQRQWLSSE RLEKQSAYWK QTLSGVPTLL NLPTDRTRPE QQSFMGAFIP
IELNVELTRA LKRLGQQHGV TLFTILLSAW AVVLSRLSGQ EDIVIGAPSA NRRHREIEPL
VGFFVNTLAL HVDLSNTPSV AELLARVCDR VIKAQDHQDL PFEQVVEIVQ PARRLSHTPL
FQVVFAWQNY EAGKWILPGI EVSSADFAYN RVKFDLELNL SEVDDQIIGT LGYASELFEA
ATIERQVGYL KAVLTEMVKD TSQDVTLIDF LDESERSLLL RDWNKTNVSY LDHLCIHHLF
EEQVAFNPEA TALCFENVAL SYGELNVKAN RLAHQLMDLG VGPDQLVAIC VERSPAMVVG
LLAILKAGGA YVPLDPVYSS ERLAYILADT APTLVLADVT GQQVLGEVLQ AYTVLDPNEI
RLKNGVEADI NPKIPSLTPS NLAYVIYTSG STGQPKGVMV EHAQIVRLFD TTHSAYHFKS
SDVWCLFHSF AFDFSVWELW GALRYGGRLI LVSHPVTRSP QAFYQLICEQ GVTILNQTPS
AFNALMEYVK PSSDQLRYII FGGEALQLST LRDWYAVHDE FMPQLVNMYG ITEITVHATY
CPLSSSSIQQ AESLIGKRLP DLHLYLLDIH GQPVPMGTVG EIYIGGAGVA RGYLNRPELT
AERFLPDPFA GISDARMYKS GDLARYLPNG NLVFFGRNDE QVKIRGFRIE PGEIAARLTE
HQSVREAVVV AQGSDIDKRL VAYIVVQPEV SVSIATNTSL SGKLHDYLSE RLPDYMVPSA
FVRMEKLPLT SNGKLDRGML PNPENEAFVH ATYEAPLGKI EITLATIWSE LLEIEQIGRH
DNFFALGGHS LMAVRLMERL RGIGFSLAVR DLFQTPVLSV LARTVGQHQE VAVPPNLIKL
DTIQITPELL PLIELSQIEI DRIVSQVPGG VTNIQDIYAL SPLQDGILFH HLLAKEGDPY
LLVAQMAFTD HKALERYLNA VQRVVDRHDI LRTAFVWEQL SKPVQVVWRQ APLSVTKLIL
DPADGPIIEQ LSQRFDPCQY RIDLTRAPIL RFVVAHDPVE NKFILLQLRH HLIDDASSLQ
FFYREVQAFL ADQGEALPSP EPFRNLIGQA YLGTSKETHE CFFKSMLGEV EEPTHPFGLV
EVHQNGAEVE ESFRMISAKL NDQLRTQAKL LNVSLASLCH VAFAQVLARI SNREQVVFGT
VLFGRMQAGH GADKTMGLFI NTLPIRLDIG NIGTEDSVRQ AQARLADLLS HEHASLALAQ
RCSGVTPGTP LFSALFNYRH NDLLIQKNIG QITEQMTDIE FLGEQERTNY PFTLSVEDFG
QALGLTVQVL KPLDPERVCS YMERVLESLA DTLKQSPGRS VQQLDIMPES ERTLLFKTWN
TTNIPYSDHL CIHHLFEEQV TYCPTATALI FEDTELSYGK LNAKANQLAN WLIDLGVAPE
QLVAICVERS PVMVICLLAI LKAGGAYVPL DPSYPSERLT YILTNTAPVM VLADTVGNQV
LGKALRPYTV LDPNDIWLEN WMEADINPKI SSLTPNNLAY IIYTSGSTGQ PKGVMVEHRS
LVASTLARTH IYKPESNVKF LLLSSIAFDS SVAGIFGTLT TGGTLCLPSS NTVADPKIIS
DLLIKHKVTS VLLVPSLAQL VLPQLSLQRY SQLRQVIVAG ELCPAKLINE SILTFPSVEF
FNEYGPTEAT VWASVYRCKP DESSPVPIGR PISNTRIYLL DTHGQPVPIG AVGEIYIGGA
GVARGYLNRP ELTAKHFLPD PFADTSDARM YKSGDLARYL PDGNLMFLGR NDEQIKMRGF
RIEPSEIVAR LVEHCSIQEA VVVAQGSDAD KRLIAYIVTQ PEVSASDAKN TSLARKLRDY
LSQSLPDYMI PSAFVRIESL PLTPNGKLDQ RALPVLGIEV LAHEVYEVPQ GEIEITLAAL
WSELLGVEQV GRHDSFFALG GHSLNALQLM QKIRNYGFNC SLNEIFEYPL LANFACQITQ
TPLLQPYKGA LPVRIGGAEP PIFFVPSGLG DFSYVISLAQ YIRVNCPIYI LPWSSIDESY
SSTMEVMAER MFPLIQAIQP QGPYRIAGYS SGGILAYAIV HALICKNEDV EFLGFIDVPA
PHKLQHNNLN INQYFAEHVR VATLETERHK FDELSKYIES TEIGELIEKA IKLGCYHSDG
DILLEVTKWQ AIYHFSQIAG NYEPIPLPVS LHHFYASNHE NLNLPQTDVV GGWKEALPNI
IMHFVSIPGG HVTMMADADN RKYLAEAFNL ALLQKNSSDQ
//