ID A0A2D0L8R3_9GAMM Unreviewed; 697 AA.
AC A0A2D0L8R3;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=RTX toxin {ECO:0000313|EMBL:PHM72084.1};
GN ORFNames=Xkoz_02476 {ECO:0000313|EMBL:PHM72084.1};
OS Xenorhabdus kozodoii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Xenorhabdus.
OX NCBI_TaxID=351676 {ECO:0000313|EMBL:PHM72084.1, ECO:0000313|Proteomes:UP000221101};
RN [1] {ECO:0000313|EMBL:PHM72084.1, ECO:0000313|Proteomes:UP000221101}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17907 {ECO:0000313|EMBL:PHM72084.1,
RC ECO:0000313|Proteomes:UP000221101};
RX PubMed=28993611; DOI=10.1038/s41564-017-0039-9;
RA Tobias N.J., Wolff H., Djahanschiri B., Grundmann F., Kronenwerth M.,
RA Shi Y.M., Simonyi S., Grun P., Shapiro-Ilan D., Pidot S.J., Stinear T.P.,
RA Ebersberger I., Bode H.B.;
RT "Natural product diversity associated with the nematode symbionts
RT Photorhabdus and Xenorhabdus.";
RL Nat. Microbiol. 2:1676-1685(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHM72084.1}.
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DR EMBL; NJCX01000017; PHM72084.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2D0L8R3; -.
DR OrthoDB; 6828292at2; -.
DR Proteomes; UP000221101; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd18567; ABC_6TM_CvaB_RaxB_like; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005074; Peptidase_C39.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221; ATP-BINDING CASSETTE SUB-FAMILY B; 1.
DR PANTHER; PTHR24221:SF606; COLICIN V SECRETION-PROCESSING ATP-BINDING PROTEIN; 1.
DR Pfam; PF00664; ABC_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF03412; Peptidase_C39; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50929; ABC_TM1F; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS50990; PEPTIDASE_C39; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 169..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 206..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..139
FT /note="Peptidase C39"
FT /evidence="ECO:0000259|PROSITE:PS50990"
FT DOMAIN 173..452
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 486..696
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 697 AA; 78903 MW; ADD8A0CE2E283CAE CRC64;
MIKLNQIRFW SSNSLPVILQ SEIAECGLAC LASIASFHGY QVDLLSLRRK FSIPLTGINL
NDITNYAKEL NLSYRAIRLD INEIEQLTLP CLLHWGLNHF VVLKKISSKK IIIMDPSVGI
RHLSFDDFSD YFTGVAVEFW PNNDFKKDVL KERVNVSKFI RNISGVKKAI IKILLLAFAL
EFFALISPYY MQLIIDHGVV SEDKNLILLL SFGFGILLIF EQIITIVQSL LTTYISTNLN
IQWKSNVFTH LISLSIDFFR KRHLGDILSR FSSIDSIQNT LTSSFFISIC NSLVSVITFF
IMLMYNLKLT LISITTLLIY IVIRIIWYFP LREISKENIT HAAKQSSNFM ETIRGMKTIK
IFGKESYRYN SWLSLSIDTL NSSLKTQRLS LLFSFLNKML FGIQNILIVY LGTILIFDNV
FTIGILISFL AYKSQFESRV LSLIDQFVSL KMLGIHLDRL SDIVLTETEF NSDVSLKEKE
ILSSNVKVKN LCFKHNDDSP YLIKDLSFNI PAGGSAAIIG ASGCGKSTLL NLMMGSILPT
EGKVIIGNVV VNKSHIKSIR NSIGYVAQDD TLFSGSIMDN ITFFDEKPNI EKSVNCAKIA
AIHDDIMKMP MKYETLIGDM GTILSGGQKQ RLCLARALYK DPKILFLDEA TSHLDIENEM
IISSNLKCLN ITKIMVAHRK ETIESANIII NLNNFKS
//
