ID A0A2D0LFW8_9GAMM Unreviewed; 904 AA.
AC A0A2D0LFW8;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=HTH-type transcriptional regulator MalT {ECO:0000256|HAMAP-Rule:MF_01247};
DE AltName: Full=ATP-dependent transcriptional activator MalT {ECO:0000256|HAMAP-Rule:MF_01247};
GN Name=malT {ECO:0000256|HAMAP-Rule:MF_01247};
GN ORFNames=Xkoz_00755 {ECO:0000313|EMBL:PHM74513.1};
OS Xenorhabdus kozodoii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Xenorhabdus.
OX NCBI_TaxID=351676 {ECO:0000313|EMBL:PHM74513.1, ECO:0000313|Proteomes:UP000221101};
RN [1] {ECO:0000313|EMBL:PHM74513.1, ECO:0000313|Proteomes:UP000221101}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17907 {ECO:0000313|EMBL:PHM74513.1,
RC ECO:0000313|Proteomes:UP000221101};
RX PubMed=28993611; DOI=10.1038/s41564-017-0039-9;
RA Tobias N.J., Wolff H., Djahanschiri B., Grundmann F., Kronenwerth M.,
RA Shi Y.M., Simonyi S., Grun P., Shapiro-Ilan D., Pidot S.J., Stinear T.P.,
RA Ebersberger I., Bode H.B.;
RT "Natural product diversity associated with the nematode symbionts
RT Photorhabdus and Xenorhabdus.";
RL Nat. Microbiol. 2:1676-1685(2017).
CC -!- FUNCTION: Positively regulates the transcription of the maltose regulon
CC whose gene products are responsible for uptake and catabolism of malto-
CC oligosaccharides. Specifically binds to the promoter region of its
CC target genes, recognizing a short DNA motif called the MalT box.
CC {ECO:0000256|HAMAP-Rule:MF_01247}.
CC -!- ACTIVITY REGULATION: Activated by ATP and maltotriose, which are both
CC required for DNA binding. {ECO:0000256|HAMAP-Rule:MF_01247}.
CC -!- SUBUNIT: Monomer in solution. Oligomerizes to an active state in the
CC presence of the positive effectors ATP and maltotriose.
CC {ECO:0000256|HAMAP-Rule:MF_01247}.
CC -!- SIMILARITY: Belongs to the MalT family. {ECO:0000256|HAMAP-
CC Rule:MF_01247}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHM74513.1}.
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DR EMBL; NJCX01000004; PHM74513.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2D0LFW8; -.
DR OrthoDB; 1123107at2; -.
DR Proteomes; UP000221101; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0045913; P:positive regulation of carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR CDD; cd06170; LuxR_C_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_01247; HTH_type_MalT; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR023768; Tscrpt_reg_HTH_MalT.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR44688; -; 1.
DR PANTHER; PTHR44688:SF7; HTH-TYPE TRANSCRIPTIONAL REGULATOR MALT; 1.
DR Pfam; PF00196; GerE; 1.
DR Pfam; PF17874; TPR_MalT; 1.
DR PRINTS; PR00038; HTHLUXR.
DR SMART; SM00421; HTH_LUXR; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS00622; HTH_LUXR_1; 1.
DR PROSITE; PS50043; HTH_LUXR_2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|HAMAP-Rule:MF_01247};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_01247};
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277, ECO:0000256|HAMAP-
KW Rule:MF_01247};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_01247}; Kinase {ECO:0000313|EMBL:PHM74513.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_01247}; Transcription {ECO:0000256|HAMAP-Rule:MF_01247};
KW Transcription regulation {ECO:0000256|HAMAP-Rule:MF_01247};
KW Transferase {ECO:0000313|EMBL:PHM74513.1}.
FT DOMAIN 832..897
FT /note="HTH luxR-type"
FT /evidence="ECO:0000259|PROSITE:PS50043"
FT BINDING 39..46
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01247"
SQ SEQUENCE 904 AA; 104040 MW; 8BCD10A0543AC3A6 CRC64;
MLIPSKLSRP LRLSNMVMRE RLLEKFNEIQ NYRLVLITSP AGYGKTTLMS QWAAGQEHLG
WYSLDDSDNQ PERFASYLIA AIQQATQGHC VKSEVLAQKH QYASLPALIA QLFIELNEWQ
KPIFLVIDDY HLIGNGLVHE AMRFFLRHQP ENLTLVVLSR HLPSLGIANL RVREQLLEID
SHQLAFDYQE TQQFFAKRLA NPLEPEHCKQ LCNEVAGWAT ALQLIALSAR QSSNTTEISA
KRLSGINASH LADYLVDEVL NRVDQATRDF LLHSSILRSM NDGLIACLTG EENGQQHLED
IERQGLFIQR LDDSGEWFCF HPLFASFLRQ RCQWEMAAKL PELHRAAVKG WLMQGYPGEA
IHHALAAGDT LLLRDILLQH AWELFNHSKL SLLEECMNAL PYELLLESPR LVLLQAWLAQ
SQYRYYEVNA LLNQAEQSLK QKQIAIEPEL LAEFNALRAQ VAMNDGRPAD ADALAEKALA
NLLPDNQYGR IVAMSVRGEV LHCNGQLASA LALMKQTEQL ARLCHSYHYA LWALLQQSEI
LLAQGYLQAA YDTQSHAFDL IREQHLEQLP MHEFLLRLRS QLLWCWARID ESEEVARQGL
DVLANYQPQQ QLQCLTQLAK CSLVRGDIDN ARRYLIRCEN LLSNGQYHRD WRTNTDELRV
IIWQTLEDSS ALTQWLAQAE RPESFCNHFN QNQWRNIARV KILLDQYKEA ESILLKLNEY
ARRLALVSDL NRNLLLCNLL YWQLGRKAEA QGVLIEALNL ANRTGFISHF VIEGELMALQ
LRQLIQLNIL PEMEQHRAQR ILREINRQHR HKFAHFDETF VEQLLTHPDV PELIRNSPLT
QREWQVLGLI YSGYSNDQIA AELEVAATTI KTHIRNLYQK MGIAHRQDAI SQAQKLMRMM
GLGV
//
