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Database: UniProt
Entry: A0A2D0PIW9_ICTPU
LinkDB: A0A2D0PIW9_ICTPU
Original site: A0A2D0PIW9_ICTPU 
ID   A0A2D0PIW9_ICTPU        Unreviewed;      2735 AA.
AC   A0A2D0PIW9;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   16-JAN-2019, entry version 6.
DE   SubName: Full=inositol 1,4,5-trisphosphate receptor type 1 isoform X13 {ECO:0000313|RefSeq:XP_017305882.1};
GN   Name=itpr1 {ECO:0000313|RefSeq:XP_017305882.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|Proteomes:UP000221080, ECO:0000313|RefSeq:XP_017305882.1};
RN   [1] {ECO:0000313|RefSeq:XP_017305882.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017305882.1};
RG   RefSeq;
RL   Submitted (NOV-2017) to UniProtKB.
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DR   RefSeq; XP_017305882.1; XM_017450393.1.
DR   UniGene; Ipu.76932; -.
DR   GeneID; 108254919; -.
DR   CTD; 3708; -.
DR   OrthoDB; 94996at2759; -.
DR   Proteomes; UP000221080; Genome assembly.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000221080};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_017305882.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000221080};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2263   2285       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2297   2315       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2343   2361       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2381   2408       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2429   2451       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2556   2579       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      112    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      173    223       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      231    287       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      294    377       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      383    439       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     1619   1639       {ECO:0000256|SAM:Coils}.
FT   COILED     2666   2714       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2735 AA;  310729 MW;  1C91B9275087E2A6 CRC64;
     MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PESGDLNSPP KKFRDCLFKL
     CPMNRYSAQK QFWKAAKPGG NSTTDTVLLN KLHHAADLEK KQNESENRKL LGTVIQYGNV
     IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDSAGNEGSW FYIQPFYKLR SIGDSVVIGD
     KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK EVILKGGDVV
     RLFHAEQEKF LTCDDYRKKH YVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN
     SLFRFKHLAT GHYLAAEGSS EVNPDYEEES QESRSSLDLE HEALRARLRT PNEKVMYTLI
     SVPDGNDISS IFELDPTTLR GGDSLVPRSS YVRLRHLCTN TWVHSTNNPI DKEEEKPVML
     RIGTSAIKED KEAFAIVPVP PAEVRDLDFA NDASKVLASI AGKLEKGTIT QNERRFVTKL
     LEDLVFFVVD IPNSGQDVLE IMVNKPNRER QKLMREQNIL KQIFKLLQAP FTDSGDGPML
     RLEELGDQRH APFRHICRLC YRVLRHSQQD YRKNQEYIAK QFRFMQKQIG YDVLAEDTIT
     ALLHNNRKLL EKHITAAEID TFVSLVRKNR EPRFLDYLSD LCVSMNKSIP VTQELICNAV
     LDTANADILI ETKLVLSRFE IDTLNAGEPP LETEEDVEEV WLFWKDSGKE IRSKSIKELA
     QDAKEGQKED QEVVSYYRYQ LNLFARMCLD RQYLAINKIS GQLDVDLILH CMSDEDLPYD
     LRASFCRLML HMHVDRDPQE PVTPVKYARL WSEIPSKIAI DDYDNDGTTR DEIKERFALT
     MEFVESYLRI VVCQNVPFSD KEKNKLTFEV VNLARNLIYF GFYSFSDLLR LTKILLAILD
     CVHVSTIYPM NKMEKGDENK GSNVMRSIHG VGELMTQVVL RGGGFLPSTP AAPTDGEVGK
     TQTEPEKEDI LVMDTKLKII EILQFILNVR LDYRISCLLC IFKKEFDGSN TQTDTLPNPN
     ANANANANGN TSGNSTTTAT ANGDGPNSIP ALDFEKIEEQ AEGIFGASEE NTPLDLDDHG
     GRTFLRVLLH LTMHDYPPLV SGALHLLFRH FSQRQEVLMA FKQVQLLVTS QDVDNYKQIK
     SDLDQLRSIV EKSELWVYKR QGDDVLDGGD GPSESDHKKK GDSSGMEKNQ TESTSSYNYR
     VVKEILLRLS KLCVQEGASG KKSKKQQQRL LRNMGAHAVV LELLQIPYEK GEDVRMQEIM
     KLAHEFLQNF CAGNQQNQAL LHKHINLFLN PGILEAVTMQ HIFMNNFQLC SEINDRVVQH
     FVHCIESHGR HVQYLKFLQT IVKAENKFIK KCQDIVMAEL VNAGEDVLVF YNDRASFQTL
     VQMMRSERDR MDENSPLMYH IHLVELLAVC TEGKNVYTEI KCNSLLPLDD IVRVVTHEDC
     IPEVKIAYID FLNHCYVDTE VEMKEIYTSN HMWKLFENFL VDICRVCNST SDRKHADATL
     ERYVTETVMS IVTTFFSSPF SDQSTSLQTR QPVFVQLLQG VFRVYHCSWL TPTQKASVES
     CIKVLSDVAK SRAIAIPVDL DSQVNNLFVK SNNVVQKTIL NWRMSARNAS RRDSTIGTSK
     DYRNIIERLQ DIVSSLEDRL RPLVQAELSV LVDVLHRPEL LFPENTEARK KCESGGFISK
     LIKHTKQLLE ENEERLCIKV LQTLREMMTK DRGYGEKGEA LRQILVNRYY GNFKPGGRRD
     SLTTFSNGPL GPGPQSKAPT ASSGCPVGAR GELSLAEVQC HLDREGASDL VIDLIMNATS
     DRIFQESILL AIALLEGGNP VIQRSFFIRL TRDNKSEKFF KVFYERMKLA QQEIKATVTV
     NTSDLGSKRK DEDTNDKEAP AKKKVKDVAV VTEEVREQLL EASTVTKKAF TAYRREVDSD
     EHLGGGEVPS ASAEKNQDEN EMSVTITIMQ PILRLMQLLC ENHNRELQNF LRCQNNKNNY
     NLVCETLQFL DCICGSTTGG LGLLGLYINE QNVALINQTV ESLTEYCQGP CHENQNCIAT
     HECNGIDIII ALILNDINPL GKKRMDLVLE LKNNASKLLL AIMESRHDSE NAERILYNMR
     PKELVEVIKK AYMQGEVEVE HSEEDGEGEE EHAASPRNVG HNIYILAHQL ARHNKELQAM
     LKAGGTYGEG DEALEFYAKH TAQIEIVRLD RTMEQIVFPV PNICEFLTQE SKLRVYYTTE
     RDEQGSKIND FFLRSEDLFN EMNWQKKLRA QPILYWCSRN MSFWSSISFN LAVLMNLLVA
     FFYPLEGVRR GTLEPHLSAL LWAAMLVSLA IVIVLPQPHG IRALIASTIL RLIFSVGLEP
     TLFLLGAFNV CNKVIFLMSF VGNRGTFTRG YKAMIMDVEF LYHLLYLIIC ILGVFVHVFF
     YSLLLFDLIY REETLLNVIK SVTRNGRSIV LTAVLALILV YLFSIVGYII FKDDFILAVD
     RIPNKTLDQT ATVMSEFLSG GACQKEGGGE NCSAEATVES VAAVVVEDKE RTCDSLLMCI
     VTVLSHGLRS GGGVGDVLRK PSKEEPLFAA RVIYDLLFFF MVIIIVLNLI FGVIIDTFAD
     LRSEKQKKEE VLKTTCFICG LERDKFDNKT VTFEEHIKVE HNMWHYLFFI VLIKVKDSTE
     YTGPESYVAE MIREHNLDWF PRMRAMSLVS SDAEGEQNEI RNLQEKLEST MKLVSNLSGQ
     LTELKEQMTE QRKQKQRIGL LGHPQHMNVN PQQPA
//
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