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Database: UniProt
Entry: A0A2D0PIZ2_ICTPU
LinkDB: A0A2D0PIZ2_ICTPU
Original site: A0A2D0PIZ2_ICTPU 
ID   A0A2D0PIZ2_ICTPU        Unreviewed;      2244 AA.
AC   A0A2D0PIZ2;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   16-JAN-2019, entry version 6.
DE   SubName: Full=inositol 1,4,5-trisphosphate receptor type 1 isoform X11 {ECO:0000313|RefSeq:XP_017305879.1};
GN   Name=itpr1 {ECO:0000313|RefSeq:XP_017305879.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|Proteomes:UP000221080, ECO:0000313|RefSeq:XP_017305879.1};
RN   [1] {ECO:0000313|RefSeq:XP_017305879.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017305879.1};
RG   RefSeq;
RL   Submitted (NOV-2017) to UniProtKB.
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DR   RefSeq; XP_017305879.1; XM_017450390.1.
DR   UniGene; Ipu.76932; -.
DR   GeneID; 108254919; -.
DR   CTD; 3708; -.
DR   OrthoDB; 94996at2759; -.
DR   Proteomes; UP000221080; Genome assembly.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000221080};
KW   Receptor {ECO:0000313|RefSeq:XP_017305879.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000221080};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904}.
FT   DOMAIN      112    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      173    223       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      231    287       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      294    377       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      383    439       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     1625   1645       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2244 AA;  254448 MW;  0D09289E3640444A CRC64;
     MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PESGDLNSPP KKFRDCLFKL
     CPMNRYSAQK QFWKAAKPGG NSTTDTVLLN KLHHAADLEK KQNESENRKL LGTVIQYGNV
     IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDSAGNEGSW FYIQPFYKLR SIGDSVVIGD
     KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK EVILKGGDVV
     RLFHAEQEKF LTCDDYRKKH YVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN
     SLFRFKHLAT GHYLAAEGSS EVNPDYEEES QESRSSLDLE HEALRARLRT PNEKVMYTLI
     SVPDGNDISS IFELDPTTLR GGDSLVPRSS YVRLRHLCTN TWVHSTNNPI DKEEEKPVML
     RIGTSAIKED KEAFAIVPVP PAEVRDLDFA NDASKVLASI AGKLEKGTIT QNERRFVTKL
     LEDLVFFVVD IPNSGQDVLE IMVNKPNRER QKLMREQNIL KQIFKLLQAP FTDSGDGPML
     RLEELGDQRH APFRHICRLC YRVLRHSQQD YRKNQEYIAK QFRFMQKQIG YDVLAEDTIT
     ALLHNNRKLL EKHITAAEID TFVSLVRKNR EPRFLDYLSD LCVSMNKSIP VTQELICNAV
     LDTANADILI ETKLVLSRFE IDTLNAGEPP LETEEDVEEV WLFWKDSGKE IRSKSIKELA
     QDAKEGQKED QEVVSYYRYQ LNLFARMCLD RQYLAINKIS GQLDVDLILH CMSDEDLPYD
     LRASFCRLML HMHVDRDPQE PVTPVKYARL WSEIPSKIAI DDYDNDGTTR DEIKERFALT
     MEFVESYLRI VVCQNVPFSD KEKNKLTFEV VNLARNLIYF GFYSFSDLLR LTKILLAILD
     CVHVSTIYPM NKMEKGDENK GSNVMRSIHG VGELMTQVVL RGGGFLPSTP AAPTDGEVGK
     TQTEPEKEDI LVMDTKLKII EILQFILNVR LDYRISCLLC IFKKEFDGSN TQTDTLPNPN
     ANANANANGN TSGNSTTTAT ANGDGPNSIP ALDFEKIEEQ AEGIFGASEE NTPLDLDDHG
     GRTFLRVLLH LTMHDYPPLV SGALHLLFRH FSQRQEVLMA FKQVQLLVTS QDVDNYKQIK
     SDLDQLRSIV EKSELWVYKR QGDDVLDGGD GPSESDHKKK GDSSGMEKNQ TESTSSYNYR
     VVKEILLRLS KLCVQEGASG KKSKKQQQRL LRNMGAHAVV LELLQIPYEK GEDVRMQEIM
     KLAHEFLQNF CAGNQQNQAL LHKHINLFLN PGILEAVTMQ HIFMNNFQLC SEINDRVVQH
     FVHCIESHGR HVQYLKFLQT IVKAENKFIK KCQDIVMAEL VNAGEDVLVF YNDRASFQTL
     VQMMRSERDR MDENSPLMYH IHLVELLAVC TEGKNVYTEI KCNSLLPLDD IVRVVTHEDC
     IPEVKIAYID FLNHCYVDTE VEMKEIYTSN HMWKLFENFL VDICRVCNST SDRKHADATL
     ERYVTETVMS IVTTFFSSPF SDQSTSLQMA RHMYTRQPVF VQLLQGVFRV YHCSWLTPTQ
     KASVESCIKV LSDVAKSRAI AIPVDLDSQV NNLFVKSNNV VQKTILNWRM SARNASRRDS
     TIGTSKDYRN IIERLQDIVS SLEDRLRPLV QAELSVLVDV LHRPELLFPE NTEARKKCES
     GGFISKLIKH TKQLLEENEE RLCIKVLQTL REMMTKDRGY GEKLIAFDDE LDVAEDLDPN
     QPQKQLEDQK RGEALRQILV NRYYGNFKPG GRRDSLTTFS NGPLGPGPQS KAPTASSGCP
     VGARGELSLA EVQCHLDREG ASDLVIDLIM NATSDRIFQE SILLAIALLE GGNPVIQRSF
     FIRLTRDNKS EKFFKVFYER MKLAQQEIKA TVTVNTSDLG SKRKDEDTND KEAPAKKKVK
     DVAVVTEEVR EQLLEASTVT KKAFTAYRRE VDSDEHLGGG EVPSASAEKN QDENEMSVTI
     TIMQPILRLM QLLCENHNRE LQNFLRCQNN KNNYNLVCET LQFLDCICGS TTGGLGLLGL
     YINEQNVALI NQTVESLTEY CQGPCHENQN CIATHECNGI DIIIALILND INPLGKKRMD
     LVLELKNNAS KLLLAIMESR HDSENAERIL YNMRPKELVE VIKKAYMQGE VEVEHSEEDG
     EGEEEHAASP RNVGHNIYIL AHQLARHNKE LQAMLKAGGT YGEGDEALEF YAKHTAQIEL
     SPFCTGARET CPSGAASPST WRSS
//
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