ID A0A2D0PK73_ICTPU Unreviewed; 392 AA.
AC A0A2D0PK73;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Southpaw {ECO:0000313|RefSeq:XP_017307023.1};
GN Name=spaw {ECO:0000313|RefSeq:XP_017307023.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017307023.1};
RN [1] {ECO:0000313|RefSeq:XP_017307023.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017307023.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; XP_017307023.1; XM_017451534.3.
DR AlphaFoldDB; A0A2D0PK73; -.
DR STRING; 7998.ENSIPUP00000030607; -.
DR Ensembl; ENSIPUT00000031837; ENSIPUP00000030607; ENSIPUG00000020679.
DR GeneID; 108255530; -.
DR KEGG; ipu:108255530; -.
DR CTD; 338101; -.
DR OMA; CHQVGDR; -.
DR OrthoDB; 5393576at2759; -.
DR Proteomes; UP000221080; Chromosome 22.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd13759; TGF_beta_NODAL; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF159; NODAL HOMOLOG; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..392
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012316414"
FT DOMAIN 260..392
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 181..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 392 AA; 44508 MW; 8B86E813F66700AB CRC64;
MGLARALALM LALASLDCLG IKQQSARHRA EHPSAHGYSA GEDRPHRYPV YMMQLYRDYR
NTAAGVSGHA LHQTDSVLSL VAKDCHQDGE RWKVTFDMSS LSGSQEIRLS ELRFRVPAFS
ASVVELYHMH NSAPEERIFL GSIKVTPGRT SSSSSSSSWK AFNVTDLLTY WLRQEGEGQW
PANQFVPEND MPSDVEEGSG KDDTEPSSRR TIQHLTTDRV MIVVFLKSAL TQGHQSSPTL
MQTVQHSKYV ALDRPGNARR HKRNRMEPGH VREVASENVT GPVTESRQRP LCRRVDMWVD
FDQIGWNEWI VHPKRYNAYR CEGDCPVPLD ESFKSTNHAY MQSLLKLYHP ERVTCTLCAP
TRLSSLSMLY YEGDDVVLRH HEDMIVEECG CQ
//
