ID A0A2D0PL30_ICTPU Unreviewed; 439 AA.
AC A0A2D0PL30;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Rab5 GDP/GTP exchange factor {ECO:0000313|RefSeq:XP_017307313.1, ECO:0000313|RefSeq:XP_017307314.1};
GN Name=LOC108255693 {ECO:0000313|RefSeq:XP_017307313.1,
GN ECO:0000313|RefSeq:XP_017307314.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017307313.1};
RN [1] {ECO:0000313|RefSeq:XP_017307313.1, ECO:0000313|RefSeq:XP_017307314.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017307313.1,
RC ECO:0000313|RefSeq:XP_017307314.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_017307313.1; XM_017451824.3.
DR RefSeq; XP_017307314.1; XM_017451825.3.
DR STRING; 7998.ENSIPUP00000030102; -.
DR Ensembl; ENSIPUT00000031316; ENSIPUP00000030102; ENSIPUG00000020340.
DR GeneID; 108255693; -.
DR KEGG; ipu:108255693; -.
DR OMA; WTEKQRG; -.
DR OrthoDB; 20678at2759; -.
DR Proteomes; UP000221080; Chromosome 22.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.10.246.120; -; 1.
DR Gene3D; 1.20.5.4770; -; 1.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR041545; DUF5601.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR045046; Vps9-like.
DR InterPro; IPR037191; VPS9_dom_sf.
DR InterPro; IPR002653; Znf_A20.
DR PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23101:SF103; RAB5 GDP_GTP EXCHANGE FACTOR; 1.
DR Pfam; PF18151; DUF5601; 1.
DR Pfam; PF02204; VPS9; 1.
DR Pfam; PF01754; zf-A20; 1.
DR SMART; SM00167; VPS9; 1.
DR SMART; SM00259; ZnF_A20; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS51205; VPS9; 1.
DR PROSITE; PS51036; ZF_A20; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 12..46
FT /note="A20-type"
FT /evidence="ECO:0000259|PROSITE:PS51036"
FT DOMAIN 204..347
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT REGION 45..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 356..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..78
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 439 AA; 49766 MW; 42AD0EB88A4DCE7D CRC64;
MWAEQKRGIH VTQAELLCKD GCGFYGNPAW QGYCSKCWRK RTRTTETSKE DHGLQDEGSS
QLNLFKTEEK KNAEKGRRSS TIMRLFWGSS SPPRQESPEG QEAALKAFQS LEPGDFPGFL
KLLRKPSSQR LQSRCTAFLN TIDAYHDLPV QKQSDLVQDF YQNITVHFSG LPEPQVSHMM
EHVEKLIMTR LHKWVFCHDS CDDEQKDLTL QRRIKSLNWV TPEMLRVPFP QGGSDTSDPY
LPAITAIIEM DAKRAPQDKL ACLSKCSQHV FQALASENRQ PANADDFLSG LIYVVLRANP
PRLHSNINYI VRFGLPHSLM AGESGYYFTN LSCTVAFIEK LDGPALNLTP EEFNSCMQGR
RAPSGPAERA GQKRAQENRE QLEQLKNRQE KIDQGARALQ EQLDLWVRSV QDQIDEVRAQ
SVLVLKDDVA EVPPGETVC
//
