ID A0A2D0PL46_ICTPU Unreviewed; 494 AA.
AC A0A2D0PL46;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Scavenger receptor class A member 5 {ECO:0000256|HAMAP-Rule:MF_03070};
GN Name=scara5 {ECO:0000313|RefSeq:XP_017305785.1};
GN Synonyms=SCARA5 {ECO:0000256|HAMAP-Rule:MF_03070};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017305785.1};
RN [1] {ECO:0000313|RefSeq:XP_017305785.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017305785.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Ferritin receptor that mediates non-transferrin-dependent
CC delivery of iron. Mediates cellular uptake of ferritin-bound iron by
CC stimulating ferritin endocytosis from the cell surface with consequent
CC iron delivery within the cell. Delivery of iron to cells by ferritin is
CC required for the development of specific cell types, suggesting the
CC existence of cell type-specific mechanisms of iron traffic in
CC organogenesis, which alternatively utilize transferrin or non-
CC transferrin iron delivery pathways. {ECO:0000256|HAMAP-Rule:MF_03070}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000256|HAMAP-Rule:MF_03070}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_03070};
CC Single-pass type II membrane protein {ECO:0000256|HAMAP-Rule:MF_03070}.
CC Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane
CC protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the SCARA5 family. {ECO:0000256|HAMAP-
CC Rule:MF_03070}.
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DR RefSeq; XP_017305785.1; XM_017450296.3.
DR AlphaFoldDB; A0A2D0PL46; -.
DR GeneID; 108254884; -.
DR KEGG; ipu:108254884; -.
DR CTD; 286133; -.
DR OrthoDB; 5354783at2759; -.
DR Proteomes; UP000221080; Chromosome 2.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070287; F:ferritin receptor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006879; P:intracellular iron ion homeostasis; IEA:UniProtKB-UniRule.
DR GO; GO:0034755; P:iron ion transmembrane transport; IEA:UniProtKB-UniRule.
DR Gene3D; 3.10.250.10; SRCR-like domain; 1.
DR HAMAP; MF_03070; SCARA5; 1.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR034726; SCARA5.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR PANTHER; PTHR48071; SRCR DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR48071:SF27; SRCR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01391; Collagen; 2.
DR Pfam; PF00530; SRCR; 1.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00202; SR; 1.
DR SUPFAM; SSF56487; SRCR-like; 1.
DR PROSITE; PS00420; SRCR_1; 1.
DR PROSITE; PS50287; SRCR_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_03070};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion transport {ECO:0000256|HAMAP-Rule:MF_03070};
KW Iron {ECO:0000256|HAMAP-Rule:MF_03070};
KW Iron transport {ECO:0000256|HAMAP-Rule:MF_03070};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_03070};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|HAMAP-Rule:MF_03070};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968, ECO:0000256|HAMAP-
KW Rule:MF_03070};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_03070};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_03070}; Transport {ECO:0000256|HAMAP-Rule:MF_03070}.
FT TOPO_DOM 1..62
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03070"
FT TOPO_DOM 84..494
FT /note="Extracellular"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03070"
SQ SEQUENCE 494 AA; 54005 MW; 1855E60278765FA2 CRC64;
MENKAMYLST YEERDNGSFY EEGYDGRNLS KLNLCEEASS GKRRRKTDGC CGHLDSLSAI
KYAIVSLYIL VLLSIFGLCI AVSRSQASSE KQEALLENVT RLGDRSEALR ESLGQLPSQS
DLLENIWKLE RLFHNHSEEL RQLGRLVQGL ERDIQDLQVF SEHATGSMAQ MEEQVGSSQR
NNSALRAALA RAAASIHGQD AALHDTVGRM DVLRQKLDEV DWTVGSINHS LSSHVSTQRL
QMELLQVQLG NVTQDARSTR ITQIHLEEQM RNELEILNVI TEDLRLKDWE HSMALKNITV
IEGPPGPKGE KGDVGPLGPA GIPGLPGFRG VPGEMGIQGP RGLSGTNGVD GQIGEKGDTG
PMGPKGQRGE RGFKGEKGDR GDQGGKTAEN ALVRLMNGSA AHEGRVEVYH EGRWGTVCDD
VWDKKDGDVV CRMLGFRGAQ EVHKTGRFGQ GTGLIWMDDV ACIGTEDTIH QCKFSGWGKT
NCGHVEDAGV TCST
//
