ID   A0A2D0PLB5_ICTPU        Unreviewed;       833 AA.
AC   A0A2D0PLB5;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=atp6v0a1a {ECO:0000313|RefSeq:XP_017307393.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017307393.1};
RN   [1] {ECO:0000313|RefSeq:XP_017307393.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017307393.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   RefSeq; XP_017307393.1; XM_017451904.3.
DR   AlphaFoldDB; A0A2D0PLB5; -.
DR   Ensembl; ENSIPUT00000031741; ENSIPUP00000030513; ENSIPUG00000020528.
DR   GeneID; 108255723; -.
DR   CTD; 324307; -.
DR   OrthoDB; 1967517at2759; -.
DR   Proteomes; UP000221080; Chromosome 2.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF91; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        395..424
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        444..463
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        543..564
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        570..594
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        635..659
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        765..789
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   COILED          94..121
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   833 AA;  95259 MW;  B989AA546906B584 CRC64;
     MGELFRSEEM TLAQLFLQSE SAYCCVSELG EIGMVQFRDL NPDVNVFQRK FVNEVRRCEE
     MDRKLRFVEK EIKKANIPIV DTGENPEVPF PRDMIDLEAA FEKLEIEMKE INTNQEALKV
     NFLELTELKH ILRRTQQFFD EMEDPALLEE SSILLDPTEV VRAPLRLGFV AGVIGRERIP
     TFERMLWRVC RGNVFLRQAG IEDPLEDPTT GDQVHKSVFI IFFQGDQLKN RVKKICEGFR
     ATLYPCPETP QERKEMAAGV NTRIDDLQMV LNQTEDHRQR VLQAAAKTLR VWFIKVRKMK
     AIYHTLNLCN IDVTQKCLIA EIWCPLSDLD SIQLALRRGT EKSGSTVPSI LNRMQTKQTP
     PTYNKTNKFT SGFQNIVDAY GIGSYREMNP APYTIITFPF LFAVMFGDLG HGLLMTCAAV
     YLVLRESRLS AQKNDNEIFS MVFAGRYLIL LMGLFSMYTG IIYNDCFSKS LNVFGSSWSV
     RPMFEKGKGN WTFETLEENR LLQLDPVVPG VFGGPYPIGI DPIWNMATNK LTFLNSYKMK
     MSVILGVTHM LFGVTLSLFN HIYFKKPLNI WLGFIPEIVF MSSLFGYLVL LVFYKWTAYD
     AATSKEAPSL LIAFINMFLF NYTDPTIKPL YRGQVVIQCL LVVIALLCVP CMLIVKTLVL
     RRQYLWRKHL GTQNFGGIRV GNGPTDDEAE IIQHDHLSQN LEEEPEFDFA DVAVNQAIHT
     IEYCLGCVSN TASYLRLWAL SLAHAQLSEV LWSMVMHIGL ASRNFAGSFA LLAIFAVFAT
     LTVCILLIME GLSAFLHALR LHWVEFQNKF YSGQGFKFMP FTFDSILEGK FED
//