ID A0A2D0PLB5_ICTPU Unreviewed; 833 AA.
AC A0A2D0PLB5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN Name=atp6v0a1a {ECO:0000313|RefSeq:XP_017307393.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017307393.1};
RN [1] {ECO:0000313|RefSeq:XP_017307393.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017307393.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_017307393.1; XM_017451904.3.
DR AlphaFoldDB; A0A2D0PLB5; -.
DR Ensembl; ENSIPUT00000031741; ENSIPUP00000030513; ENSIPUG00000020528.
DR GeneID; 108255723; -.
DR CTD; 324307; -.
DR OrthoDB; 1967517at2759; -.
DR Proteomes; UP000221080; Chromosome 2.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF91; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 395..424
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 444..463
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 543..564
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 570..594
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 635..659
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 765..789
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT COILED 94..121
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 833 AA; 95259 MW; B989AA546906B584 CRC64;
MGELFRSEEM TLAQLFLQSE SAYCCVSELG EIGMVQFRDL NPDVNVFQRK FVNEVRRCEE
MDRKLRFVEK EIKKANIPIV DTGENPEVPF PRDMIDLEAA FEKLEIEMKE INTNQEALKV
NFLELTELKH ILRRTQQFFD EMEDPALLEE SSILLDPTEV VRAPLRLGFV AGVIGRERIP
TFERMLWRVC RGNVFLRQAG IEDPLEDPTT GDQVHKSVFI IFFQGDQLKN RVKKICEGFR
ATLYPCPETP QERKEMAAGV NTRIDDLQMV LNQTEDHRQR VLQAAAKTLR VWFIKVRKMK
AIYHTLNLCN IDVTQKCLIA EIWCPLSDLD SIQLALRRGT EKSGSTVPSI LNRMQTKQTP
PTYNKTNKFT SGFQNIVDAY GIGSYREMNP APYTIITFPF LFAVMFGDLG HGLLMTCAAV
YLVLRESRLS AQKNDNEIFS MVFAGRYLIL LMGLFSMYTG IIYNDCFSKS LNVFGSSWSV
RPMFEKGKGN WTFETLEENR LLQLDPVVPG VFGGPYPIGI DPIWNMATNK LTFLNSYKMK
MSVILGVTHM LFGVTLSLFN HIYFKKPLNI WLGFIPEIVF MSSLFGYLVL LVFYKWTAYD
AATSKEAPSL LIAFINMFLF NYTDPTIKPL YRGQVVIQCL LVVIALLCVP CMLIVKTLVL
RRQYLWRKHL GTQNFGGIRV GNGPTDDEAE IIQHDHLSQN LEEEPEFDFA DVAVNQAIHT
IEYCLGCVSN TASYLRLWAL SLAHAQLSEV LWSMVMHIGL ASRNFAGSFA LLAIFAVFAT
LTVCILLIME GLSAFLHALR LHWVEFQNKF YSGQGFKFMP FTFDSILEGK FED
//