ID A0A2D0PLZ3_ICTPU Unreviewed; 554 AA.
AC A0A2D0PLZ3;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=glutaminase {ECO:0000256|ARBA:ARBA00012918};
DE EC=3.5.1.2 {ECO:0000256|ARBA:ARBA00012918};
GN Name=gls2b {ECO:0000313|RefSeq:XP_017306441.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017306441.1};
RN [1] {ECO:0000313|RefSeq:XP_017306441.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017306441.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-glutamine = L-glutamate + NH4(+);
CC Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001062};
CC -!- SIMILARITY: Belongs to the glutaminase family.
CC {ECO:0000256|ARBA:ARBA00011076}.
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DR RefSeq; XP_017306441.1; XM_017450952.3.
DR AlphaFoldDB; A0A2D0PLZ3; -.
DR GeneID; 108255189; -.
DR CTD; 556445; -.
DR OrthoDB; 537490at2759; -.
DR Proteomes; UP000221080; Chromosome 21.
DR GO; GO:0004359; F:glutaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:InterPro.
DR Gene3D; 1.10.238.210; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR HAMAP; MF_00313; Glutaminase; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR015868; Glutaminase.
DR InterPro; IPR041541; Glutaminase_EF-hand.
DR NCBIfam; TIGR03814; Gln_ase; 1.
DR PANTHER; PTHR12544; GLUTAMINASE; 1.
DR PANTHER; PTHR12544:SF33; GLUTAMINASE LIVER ISOFORM, MITOCHONDRIAL; 1.
DR Pfam; PF17959; EF-hand_14; 1.
DR Pfam; PF04960; Glutaminase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 83..165
FT /note="Glutaminase EF-hand"
FT /evidence="ECO:0000259|Pfam:PF17959"
SQ SEQUENCE 554 AA; 61962 MW; 93856CC33300228C CRC64;
MMMYCLRTFG RINVGMAEFL VENGAKNGAL GLYCESARRV SRQRRCFSNG SSQLYLSKAT
TEHTEHPLTE GGRAGEGLFS GLEDLLFHTI TDGQDRIPIS HFINAVKRTG LLTSDPRLRD
CMDKLRQTVR ESNGDVMMDH KLFRRCVGGN IVLLSQAFRK KFIIPEFEAF VGVINQIYNR
AKQQHEGQVA DYIPHLAKFS PSLWGISLCT VDGQRHSTGD TKVPFCLQSC VKPLEYAIAV
HEHGTEHVHH FVGKEPSGLK FNMLYLDDDD KPHNPMVNAG AIVISSLIKP GANKAEKFDY
MMDFVKKMAG KEYVGFSNAT FQSEKETGDR NFAIGYYLKE KKCFPPGVDM IDALDFYFQL
CSIEVTCESG SVVAATLANG GICPITGEQV LSSESVRNTL SLMHSCGMYD YSGHFAFHVG
LPAKSGVSGA VLLVVPNVMG VMCWSPPVDR LGNSVRGISF CQELVSHFNF HNYDNLRHFV
KKQDPRRQSG DERNKSVVNL MFAAHSGDVS ALRRCISLLS GLHCLLWTWT RRTMTIVQLF
MLLLQKVMWK LCGF
//
