UniProt: A0A2D0PQU2

Database: UniProt
Entry: A0A2D0PQU2_ICTPU

LinkDB:  A0A2D0PQU2_ICTPU 
Original site:  A0A2D0PQU2_ICTPU

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Ontology (2)   
   GO (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (5)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (2)   
   RefSeq(pep) (2)   
Protein domain (3)   
   InterPro (1)   
   Pfam (1)   
   PROSITE (1)   
All databases (13)   

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ID   A0A2D0PQU2_ICTPU        Unreviewed;       428 AA.
AC   A0A2D0PQU2;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE            EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
GN   Name=zdhhc23b {ECO:0000313|RefSeq:XP_017308948.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017308948.1};
RN   [1] {ECO:0000313|RefSeq:XP_017308948.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017308948.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC         hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC         COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC         EC=2.3.1.225; Evidence={ECO:0000256|ARBA:ARBA00023340};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684;
CC         Evidence={ECO:0000256|ARBA:ARBA00023340};
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC       {ECO:0000256|RuleBase:RU079119}.
CC   -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00008574, ECO:0000256|RuleBase:RU079119}.
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DR   RefSeq; XP_017308948.1; XM_017453459.3.
DR   RefSeq; XP_017308949.1; XM_017453460.1.
DR   AlphaFoldDB; A0A2D0PQU2; -.
DR   STRING; 7998.ENSIPUP00000015998; -.
DR   Ensembl; ENSIPUT00000016680; ENSIPUP00000015998; ENSIPUG00000010864.
DR   GeneID; 108256516; -.
DR   KEGG; ipu:108256516; -.
DR   CTD; 445301; -.
DR   OMA; GNWSEFM; -.
DR   OrthoDB; 4152777at2759; -.
DR   Proteomes; UP000221080; Chromosome 23.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR   PANTHER; PTHR22883:SF471; PALMITOYLTRANSFERASE ZDHHC23; 1.
DR   PANTHER; PTHR22883; ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN; 1.
DR   Pfam; PF01529; DHHC; 1.
DR   PROSITE; PS50216; DHHC; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW   ECO:0000256|RuleBase:RU079119};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU079119};
KW   Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU079119};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU079119};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU079119}.
FT   TRANSMEM        103..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        131..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        161..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        295..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   DOMAIN          247..376
FT                   /note="Palmitoyltransferase DHHC"
FT                   /evidence="ECO:0000259|Pfam:PF01529"
SQ   SEQUENCE   428 AA;  47757 MW;  B8544435A5177664 CRC64;
     MKKRSNKAAE PDDTLCCCEY VDRLGGRSHV AACCCDCEDL DEACDRWMKR EPQNPDSLSR
     VAATVTDRLR VPWISGAKKV DLSLIPPLIL LPILLHIAAL HYLLGIVVLT ALPGMVLWYY
     YFTHRKKGRT LFFLSLALFS LFYMYYLFLT EVVPRGDVTN VQLGIITLGV ALTLLALMHT
     KKGPGYVKPS PADTHSTVTY HSPLQEVDSA YHNGLRHQVV IANRTSPAEQ GAEPRAVAGS
     VLEKDSGKRN WCPFCKLVRP PRAGHCRICS ACVLRLDHHC VWINSCVGQA NHRSFLLTLF
     FFLLTSLYGI SLVLQSVCPT QSLLTALLYC PDVYSQSSSA LCFTCAWYSS IVTGGLLHLL
     VLQLINVSYN VTEREARIAL RDKTGRSLVW GLIIDTGVYS RGFRSNWNEF LTMGETLEPK
     ALKPTDLV
//

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