GenomeNet

Database: UniProt
Entry: A0A2D0PQW2_ICTPU
LinkDB: A0A2D0PQW2_ICTPU
Original site: A0A2D0PQW2_ICTPU 
ID   A0A2D0PQW2_ICTPU        Unreviewed;       436 AA.
AC   A0A2D0PQW2;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   16-OCT-2019, entry version 11.
DE   SubName: Full=G protein-activated inward rectifier potassium channel 4-like {ECO:0000313|RefSeq:XP_017308392.1};
GN   Name=LOC108256255 {ECO:0000313|RefSeq:XP_017308392.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|Proteomes:UP000221080, ECO:0000313|RefSeq:XP_017308392.1};
RN   [1] {ECO:0000313|RefSeq:XP_017308392.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017308392.1};
RG   RefSeq;
RL   Submitted (NOV-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_017308392.1; XM_017452903.1.
DR   GeneID; 108256255; -.
DR   KEGG; ipu:108256255; -.
DR   KO; K04999; -.
DR   OMA; DREWIPC; -.
DR   OrthoDB; 956263at2759; -.
DR   Proteomes; UP000221080; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000221080};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609, ECO:0000313|RefSeq:XP_017308392.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000221080};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM    103    124       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    178    201       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       67    206       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      213    383       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION      388    436       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   SITE        192    192       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   436 AA;  49363 MW;  151A941B40570DF7 CRC64;
     MSNIKSHFGQ DVEKQGIKLP KIWKDTNSKI PTDRTMVVEG GVSVGGGGVA VSGDSSEIPR
     KRRQRYVEKD GKCNVHHGNV RETYRYLTDI FTTLVDLKWR FNLLVFTLVY TTTWIFFGLI
     WWLIAYIRGD LEHTDDSEWT PCVANLNGFV SAFLFSIETE TTIGYGYRVI TEKCPEGIVL
     LLVQAILGSI VNAFMVGCMF VKISQPKKRA ETLMFSQNAV ISMRDNKLCL MFRVGDLRNS
     HIVEASIRAK LIRSKQTKEG EFIPLNQTDI NVGFDTGDDR LFLVSPLIIC HEFNESSPFW
     DISQEQLARE EFEIVVILEG MVEATGMTCQ ARSSYLDSEV HWGERFTPVL SLEEGFYEVD
     YDSFHQTYPT PTPTCSAREL AELAKKGEDI PLPPLTPPIL NQNQNPDGER GEGEWDEEGE
     VESVSNGDVK KMDTEH
//
DBGET integrated database retrieval system