ID   A0A2D0PRI9_ICTPU        Unreviewed;       601 AA.
AC   A0A2D0PRI9;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2023, sequence version 2.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Glutathione hydrolase 6 {ECO:0000313|RefSeq:XP_017308051.2};
GN   Name=si:ch73-337l15.2 {ECO:0000313|RefSeq:XP_017308051.2};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017308051.2};
RN   [1] {ECO:0000313|RefSeq:XP_017308051.2}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017308051.2};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the gamma-glutamyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00009381}.
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DR   RefSeq; XP_017308051.2; XM_017452562.3.
DR   AlphaFoldDB; A0A2D0PRI9; -.
DR   STRING; 7998.ENSIPUP00000017909; -.
DR   Ensembl; ENSIPUT00000018670; ENSIPUP00000017909; ENSIPUG00000012153.
DR   KEGG; ipu:108256064; -.
DR   OrthoDB; 5324170at2759; -.
DR   Proteomes; UP000221080; Chromosome 22.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.20.40; -; 1.
DR   InterPro; IPR043137; GGT_ssub.
DR   InterPro; IPR029055; Ntn_hydrolases_N.
DR   PANTHER; PTHR47278; GLUTATHIONE HYDROLASE 6; 1.
DR   PANTHER; PTHR47278:SF1; GLUTATHIONE HYDROLASE 6; 1.
DR   Pfam; PF01019; G_glu_transpept; 2.
DR   PRINTS; PR01210; GGTRANSPTASE.
DR   SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|RefSeq:XP_017308051.2};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        53..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          100..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   601 AA;  65772 MW;  82F688CD9F1F3369 CRC64;
     MVQVDVRYTK VATDIHDEID TRANEDSDEE EQVTVYIKLR NDRLLGKAGK GLTCFRVSVA
     LVLLGIVSVF ALLQWYEWWP DPERFHSAGT NIMNISKEHG DHHHHTTLDE DDEHEDGEDG
     HHHEHTALYH HAVVLTASDN CSSIGKELLQ EGGNVVDAAI ASLLCLGVVH PHTAGVGGIV
     SAILYNNTSG SLKTIRSIAP QMSSTTFGVP SILQGIQVLH SKCGRSEWSR LFKEAITLAQ
     EGFLIDEVLG KALESYKEEI RISKLCDLFC DASGRMKSVG AIVKNQNLSE LLQSASLNEN
     NFLEMLAVKL SEDLSVNERP DFSAAIQHSH GEINDSLIIE GEKYSVLSAS LPFSGKMLSD
     ILEQVRQQSL SFRNGADFNR TSASYSALLN SIQERNNSAL AEKYPGLVDT FSLNTQNSHV
     AVLDKYGNFV IMSASLNSTW GSGRFLPSSG ILLNSFSSNI SNLPYFNMPL VLQLIEDDAS
     HTDDTQDNAE ENEVEVVAIT GGLSAIFNAA FFLHNRIDLG MSSKEAISGP LLHLEPGMSS
     AFCLSATLND SDFYMLFSDV GSELQQVDEC SDHSLSMLLR LHADHVSAYG APVANAHING
     Y
//