ID A0A2D0PS07_ICTPU Unreviewed; 1056 AA.
AC A0A2D0PS07;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Integrin alpha-3 {ECO:0000313|RefSeq:XP_017308211.1};
GN Name=itga3a {ECO:0000313|RefSeq:XP_017308211.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017308211.1};
RN [1] {ECO:0000313|RefSeq:XP_017308211.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017308211.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_017308211.1; XM_017452722.3.
DR AlphaFoldDB; A0A2D0PS07; -.
DR STRING; 7998.ENSIPUP00000000759; -.
DR Ensembl; ENSIPUT00000000805; ENSIPUP00000000750; ENSIPUG00000000549.
DR GeneID; 108256143; -.
DR KEGG; ipu:108256143; -.
DR CTD; 407685; -.
DR OMA; YMNAGGR; -.
DR OrthoDB; 3816176at2759; -.
DR Proteomes; UP000221080; Chromosome 2.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF89; INTEGRIN ALPHA-3; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 3.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 995..1019
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 296..356
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 357..412
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 416..478
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 463..613
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 615..758
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 780..981
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT REGION 1036..1056
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1056 AA; 116686 MW; 9E89C2823CA6078F CRC64;
MVRTMTSHLR TVRTVLFVVM YCDVCAGFNL DSRFAVVKEG RTPGSLFGLS VAMHRQTVGR
ARYLLLVGAP QEKAESKLRA NQTGDMYACP ITTDPKDCIR TNLITSDTVG AEDVIEGMWL
GVSVVSQGSQ KGRVMACGHR YSRTMDNGAN LRMIGKCYIR SNDLSYDEAN DGQWQDRQEV
CSPNGNQDME GMCNMGISAT MTETEVIAGA PGCYNWQGNS YVVYRNPDDM FDTQIIKLQD
MSTGNIYIGY SVGKDNGILS KDDDTVVAGA PRYNSKGAVM LMKVITIDDG TRELKELNLK
LEGEQVGSYF GNSIAIVDIN NDGWKELIVG APFYFNRRDA GGAVYVFMNE NGSFKPKTDL
MFTGLSDSGF GMAVSSIGDV NQDGFLDFAV GAPFHGSGMV YLWMGGKDGV SPKADQVIEG
SDVSNGGFKT FGYSISGGLD VDDNKYPDIV VGSLDDRVAL LRARPVIHVK KNFTVTPSLV
DPKDCESCIN MEVCFAYTLS TGEPNFKDDI IMKFTVEADV LQHSSQTRVR FTNNEKDVYT
GFLSMTSQRC ETQTLKLITF LRDKVTPVVF SLNASIVEPQ INSGQQQLQN LNLFPVLSQG
RTLTDKVEIH IQKACGADNK CESNLQMSAT FAKSLQDILP VQDGHQVLKY DSSINKLFLL
VNVTNYPSPG RLAEDAHNTE LNVSVSSSIT YSGVRPETTS VKCAPKDNFI LCELGNPLPA
NQMAVFAIVF QTSFITLDTQ KITSTLQLST LSIQNDLMPL TKVLLVDYAL KPAFHVMPSR
IQTEFSGHVI GESAIKSTSE IGSPVEFQFV VSVDEALGSH YVFSVDFNWP MEVANGKWLL
YIEEITMTGT SNSLCVPPGN IINPQNFQVT ERKSNRRKRD EQSAAHLEVV SALNPKSTRR
KTDHLNCTSG TAKCKTFSCS LYNMRKTATV TVRARLWNST MLEDYNKASL IVISGEATLK
LKTDRTAIHL DNKTYSVTFT VEVAPVIQDE VEYKVLLWII IVSALSGVLL LALIVVLLWK
CGFFRRANTR EIYEAKSQKA EMRTQPSEKD RLTEEE
//
