ID   A0A2D0PSL0_ICTPU        Unreviewed;       465 AA.
AC   A0A2D0PSL0;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Short-chain dehydrogenase/reductase family 42E member 2 {ECO:0000313|RefSeq:XP_017309543.1};
GN   Name=sdr42e2 {ECO:0000313|RefSeq:XP_017309543.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017309543.1};
RN   [1] {ECO:0000313|RefSeq:XP_017309543.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017309543.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219}.
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DR   RefSeq; XP_017309543.1; XM_017454054.3.
DR   AlphaFoldDB; A0A2D0PSL0; -.
DR   STRING; 7998.ENSIPUP00000013000; -.
DR   GeneID; 108256832; -.
DR   KEGG; ipu:108256832; -.
DR   CTD; 100288072; -.
DR   OrthoDB; 5487986at2759; -.
DR   Proteomes; UP000221080; Chromosome 24.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        436..457
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          82..351
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
SQ   SEQUENCE   465 AA;  51461 MW;  D8170F5120401BDD CRC64;
     MKENGSLCQV EQLPPGCLLE PGLNGCHSQN YKLSSRMSVG AGVRNRANGA VKALCSSPDC
     STSVRLENTE QIRRGGGGEK VLVTGGAGFF GFRLGKALAR QGISVILLDL HQPRFELPDG
     AVFLQGDVRD YDTLYKVCAG VDCIFHTASY GMSGPEQLRK EQVESVNVGG TNNTINVCCE
     RGISRLVYTS TVNVVFAGKP IEDGDEDSVP CVPLDKHIDH YSRTKAIAEH LVLTANRRPL
     HGGGLLQTCV LRPSGIYGPE ERRHLHRVMV NVERRLFSFT FGDPEARMNW VHVDNLVTAH
     VLAAEGLTPE RGCVANGQAY FINDGESVNV FDWMTPLFER LGYTRPLIRL PVSLVYSAAF
     LMEQLHVALR PVMEIPLLLT RNEVRNIAVS HTFSIEKARK ELGFSPKKYT LADSVDQYLQ
     SRPVPSASSL QESRSFLFVL MMTTMMVLVG LVVLILCPRW HQHQR
//