ID A0A2D0PTR9_ICTPU Unreviewed; 1717 AA.
AC A0A2D0PTR9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Pleckstrin homology domain-containing family G member 4B isoform X2 {ECO:0000313|RefSeq:XP_017308490.1};
GN Name=zgc:158766 {ECO:0000313|RefSeq:XP_017308490.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017308490.1};
RN [1] {ECO:0000313|RefSeq:XP_017308490.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017308490.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_017308490.1; XM_017453001.3.
DR Ensembl; ENSIPUT00000011228; ENSIPUP00000010772; ENSIPUG00000007343.
DR GeneID; 108256307; -.
DR KEGG; ipu:108256307; -.
DR OrthoDB; 2958732at2759; -.
DR Proteomes; UP000221080; Chromosome 23.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13242; PH_puratrophin-1; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45845:SF1; PLECKSTRIN HOMOLOGY AND RHOGEF DOMAIN CONTAINING G4B; 1.
DR PANTHER; PTHR45845; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 1220..1397
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1409..1516
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1034..1056
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1083..1107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1182..1219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1568..1600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1644..1663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 879..906
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 26..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..461
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..561
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1196..1212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1717 AA; 192283 MW; DDF35B300BEE078F CRC64;
MAALKREGVR DGEGRRNANS LSPFRLRETL KERADRRFSP NGKRTSESDA GEDRHRCAVG
GSTCRKRPTQ DSESLDSCIQ STLSSVYAPF GATASTVLLQ LFSVVERQYS GDGLRCLIDF
LLPAKRILHT IQRESCLRFK GLLLYHEGWP LCIHEKVVLQ LAPLHKVRLR QGDFYLQLVP
LGRKAAKLVI KCLARSGRAL AEITVPEGMY PRVFTAEFLQ DVTRERNLQP LQNCLLSAGA
AVYRTPWRNV VNPVRVRNAN EGIMQPGALS VGHLGTCSTH GSTGTLDSRR SSRDSLGSQG
ADSTASEPLP SRGTGERDSY TNAGTLPAEK KALNPGADSE GGIRRGGNAK SLSFSTDLST
PRRRQSGDSA AFETRRLFRK SYMEALQNPM NLGSSSESVP EEGGEPAVGV EVETRPRCDS
DTHAAIRGSL QRRLSPLLPL QRSFRSERRS KSLERSGKGS SKGHRTRSSS GEGSPKKLMN
GCTIRFGRLD LEMAFYSAER RGSKGDSGLP DSPSISESRR SSSAGEDSPK VLSRCVSVSA
PPPVAPPSPV APPPFPSAPP TGCSTPLLLT QLNTELLTSG AVSLPGNRDR SGRSVLQVCM
RNQVWTDERF TSRELTCLLG YYYSTLRKEK RDQGLTVLVD SRRQQASPVL FSALSQLQAS
LPNALYSVLL LSDKEASVKL ERDFSVPCEV LTSLKALLKH IDSSQLTRDL DGTFPYDHDH
YIQFRQKMEQ FCSSCSAAIS SLRSSIDVLN SSRSLDTAED VSETISQQRN LMKCVLEDSQ
LNRLRLEGGT FLARVRKEET SETQSYRDAL DTACTLYNQM DEEVHKLVIL SNKSLHQLEN
LLELRTFQEE TERIKRWFSV EAEKHLAPLD SLSFTLSSLQ EMRQSLEQFT EEAALQQKQA
AALTQDPTPV SGSALLELKQ HMNSVLQRAH TRRNELDILI NLYEFYESAQ QWMTHCEDYF
KHLDLEENIM GLSPEVLQTL QDYHNEATKF SMENFSSLND TVSTLGSPRQ LHHWNHIWTK
CQETRKQLEE ALERAAVREE PSPGSSLTSD HSKPREIPVA GVDLQCGESR SSLPEIKHTY
EFEDEKSHSA GPFSKNQSPS GSFLFPPERD KLSLLPLDDT DSDCTIDSSY SCRSEPGARH
RRPPLKKMMK KTLSSELSGH HGYLGVYIRG LELSNNTCVE KKLQRPHMKS PVLARTRSLP
SPSISQGRLG DGENKRQNSK IQHIMDEMIS TEREYVRSLS YIMEHYFPEM ERPDLPQDLR
GKRSIVFGNL EKLCDFHSQY FLKDLEQCAH SPLSVSTCFL RHEDLFGMYA LYSKNKPRSD
ALLTSHGNAF FKYKQVELED KMDLASYLLK PIQRMSKYAL LLKDLIKECS QSQEQELADL
RTAEEMVKFQ LRHGNDLLAM DAIRGCDVNL KEQGQLRCQD EFIVWCGRRK YLRHVFLFED
LILFSKTKKI EGGYDIYIYK QSFKTAEIGM TENVGDSGLR FEIWFRRRKS QDTFILQASS
AESKAAWTSI IGKILWRQAL RNRELRMQEM VSMGIGNKPY MDIKPSDAAI SDRAVDYIMK
GTESRTRSSV SVSSCDHSSP FKRPHSTISN SSSSSSSSHS SSSFMSSLNL PLFSSALHPP
LAHWHYDCIE EDELEHDAAM QPSMITEGSE SSSHSTSSDG VNSVSSVSAL SVPRHSSLTT
DSFSSESSFL CSSSVSSSPS HRFHKELNDT NSFITAL
//
