ID   A0A2D0PU76_ICTPU        Unreviewed;      1005 AA.
AC   A0A2D0PU76;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Rho guanine nucleotide exchange factor 1b isoform X4 {ECO:0000313|RefSeq:XP_017308660.1};
GN   Name=arhgef1b {ECO:0000313|RefSeq:XP_017308660.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017308660.1};
RN   [1] {ECO:0000313|RefSeq:XP_017308660.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017308660.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004370}.
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DR   RefSeq; XP_017308660.1; XM_017453171.3.
DR   AlphaFoldDB; A0A2D0PU76; -.
DR   STRING; 7998.ENSIPUP00000028387; -.
DR   Ensembl; ENSIPUT00000029543; ENSIPUP00000028387; ENSIPUG00000019227.
DR   GeneID; 108256375; -.
DR   CTD; 557983; -.
DR   OMA; KPRCRRL; -.
DR   OrthoDB; 2875542at2759; -.
DR   Proteomes; UP000221080; Chromosome 23.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041020; PH_16.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR015212; RGS-like_dom.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   PANTHER; PTHR45872:SF4; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR   PANTHER; PTHR45872; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR   Pfam; PF17838; PH_16; 1.
DR   Pfam; PF09128; RGS-like; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT   DOMAIN          449..638
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          274..391
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          906..958
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        274..293
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        320..373
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        911..949
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1005 AA;  113716 MW;  7395D6A205178007 CRC64;
     MDCEDAHNGR GLSGAHCSNP ARNIIGAEDE DFENDLDLTV DDQCSHFTSI ELLKNKPTHL
     LVFLHHVILQ FDCAPLLCYL HADLFRSLSA KETKKHFADF YNNFLDKGAI LRVTVPSQIA
     YELDRTRPDL INEDLQKRFA LEMQRMQTLE ILRQLEDFRQ KRMMGMTPNE QELTEVENHY
     PTDRVPREMK EKAVAERLLE KLTETNPAIV ADEDKCSAIF GAVAFYMKHL GVKSRAPDSK
     KGKGFFRRKV QKKDEKSKVL SILRIGGSNE VKVRLDNEGD KERSNERKNH LSITTHRAST
     ADGSALPIVG RKPGVTGPCT ESTEVLNSNI IVISSPETSQ PETGQSSSRS DHQSVSDGGD
     VSPACSNVGN AVWDPSPSID MPLEESHEKD SLDNQVLPAD GPGVLNASGC LTQQEEVEPR
     LLELEQDPPN WRELASSEVL SKLTKKETKR QEVINELFAT EHAHVRMLSV LQTVFSRPLE
     REAIVDSTEL ATIFPSLDEI IEMHYAFYEN LKKLRQEDNF VVKHISTPLL NRFNGSEGEW
     FQKLTARFCS RQSWTLVQIK NKQKKDPRFN AFILEAESKP QCRRLQLKDI IPIEMQRLTK
     YPLLLENIAK STENVVEKEN IQQAAECCRK ILNHVNEEVK YMENLLTLKD YQRRLDTSGL
     KPSNELYTEY KSFDLTSRSM VYEGPLTWRV TKEKALDVQG VLLGDLLVLL QKQDDKMLLK
     CQSKSVGAPQ EGKQMLSPII KLDSAFLRDV ATDNKAFYVI FAWESGAQIY ELVAQSVAER
     KTWTDLIKSS VEELKKSGGH TLERMRHGSM ASSSSTLSYS ASLNPPLSPI DNGPDMLKNS
     GQYKDSLTNE KFRHTHPSLI DCLAANGFDP LGYSNAPPER SATVALDEVM SLKTLLVGST
     CLSKNAQPDV ESRAEPGKQE NDGSQSQVEE HNMESQEDRQ DEETKGDEQK AIIAPLVLSH
     EQMEEVSRKL ESLEEQVKRL QNVEDEYHRL QETLAKFTIQ RPNYN
//