ID   A0A2D0PUU1_ICTPU        Unreviewed;      1095 AA.
AC   A0A2D0PUU1;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=KN motif and ankyrin repeat domain-containing protein 2 {ECO:0000256|ARBA:ARBA00040277};
GN   Name=kank2 {ECO:0000313|RefSeq:XP_017309771.1,
GN   ECO:0000313|RefSeq:XP_017309772.1, ECO:0000313|RefSeq:XP_047006552.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017309772.1};
RN   [1] {ECO:0000313|RefSeq:XP_017309771.1, ECO:0000313|RefSeq:XP_017309772.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017309771.1,
RC   ECO:0000313|RefSeq:XP_017309772.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
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DR   RefSeq; XP_017309771.1; XM_017454282.3.
DR   RefSeq; XP_017309772.1; XM_017454283.3.
DR   RefSeq; XP_047006552.1; XM_047150596.2.
DR   STRING; 7998.ENSIPUP00000020019; -.
DR   GeneID; 108256958; -.
DR   KEGG; ipu:108256958; -.
DR   CTD; 25959; -.
DR   OrthoDB; 123304at2759; -.
DR   Proteomes; UP000221080; Chromosome 24.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0030837; P:negative regulation of actin filament polymerization; IEA:InterPro.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR047184; KANK1-4.
DR   InterPro; IPR021939; KN_motif.
DR   PANTHER; PTHR24168; KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR24168:SF0; KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF12796; Ank_2; 2.
DR   Pfam; PF12075; KN_motif; 1.
DR   SMART; SM00248; ANK; 5.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 3.
DR   PROSITE; PS50088; ANK_REPEAT; 3.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Methylation {ECO:0000256|ARBA:ARBA00022481};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   REPEAT          905..929
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          977..1009
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          1010..1043
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REGION          138..190
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          521..690
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          739..827
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1075..1095
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          344..378
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        144..190
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        526..547
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        562..584
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        613..690
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1095 AA;  118066 MW;  4D8D68F08930D754 CRC64;
     MAQVLHMDTS FPGKINSTVP TSLHPKDTEA PYSVETPYGY HLDLDFLKYV NDIEKGNTIK
     RVPVQRRPRY GSLPRGYGYT GSWWTSTESL CSNASMDSRH SSYSYCAPGY HTSQRPNFNM
     ARVEKTLLDA RRKLEEEKDT RFSNLGSMHS SVAGSNTSLS SAHSFNRAQG GGSSYTPASS
     GLSTPVSPTP AHLQHVREQM AMALRKIRDL EEQVKTIPVL QVKISVLQEE KRQLSVQLKS
     QKFLGHTLGF SRGRPRGELY IDIPEEGVEA ATSKLEGGLS PTTPDGSRQD SGCEIEDTVI
     VGTLRPGTRK EVRTIGVGSD NKEKDTCQVG VGVREEDLGL LPETEVLKSK VDQLEVQLSK
     TMQELQSAQM KVDAVQKERQ GGALQADHAV RATSLGWQDQ HDLGSAGLHT LVSFTHQGQQ
     KQQRTVGIQV YTLEQPMVML RTQQCSTSTR PLSASMLEGT PQRGYAEPLS AEESIAVSSK
     QVREVLRTEL STSVPVTSPS SAMETNYSQA APLCQRLRDG EQKQQLATEV MPSHESAPQT
     ASPHSSLRSI MKHKADKEPR SASTQKNLQF IGVNGGYEST SSESSSETSD DESDASEYHE
     ATEKLPESPA HHPQAPSVST SAVSIPVIPK SSETANVHHS NTPLLLSEGS GHSITHSPAS
     DTATCQHVTK SPASDSDQWH SAIQSSTTAT APQETLILSA ESDSNQQYTT QNTAICTEHS
     SNQSPTICIA LEQVVNQPQA TSSDSQQNSN QPGVTTQQPT ALSHTTGPSH PDDSQSQTTD
     LTPYQQTVQL KASDASDQQD TGKTPVSSPT EKTCSNKAPT QESSFRGEMS DSFMTALHTL
     QKALGEPNAF SQQGARTAYT TVLQEWLRVS CHKSADTAVV RAYMDAFASV SPQLLEFVIN
     MADGNGNTAL HYTVSHSNFP VVKLLLDTGL CNADKQNKAG YTAIMLTALA AFHSESDLQT
     VLQLLRTGDV NAKASQAGQT ALMLAVSHGR GDMVRALLCC GAQVNLQDDD GSTALMCACE
     HGHVDIVRQL LSVPGCDATL TDNDGSTALS IALEASQNDI AVLLYAHLNF AKPPSPVSPK
     SQIVGSPPSS SEILK
//