ID A0A2D0PWG5_ICTPU Unreviewed; 413 AA.
AC A0A2D0PWG5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155};
DE EC=2.8.2.- {ECO:0000256|RuleBase:RU361155};
GN Name=hs3st4 {ECO:0000313|RefSeq:XP_017309475.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017309475.1};
RN [1] {ECO:0000313|RefSeq:XP_017309475.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017309475.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family.
CC {ECO:0000256|RuleBase:RU361155}.
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DR RefSeq; XP_017309475.1; XM_017453986.3.
DR AlphaFoldDB; A0A2D0PWG5; -.
DR Ensembl; ENSIPUT00000029577; ENSIPUP00000028419; ENSIPUG00000019246.
DR GeneID; 108256776; -.
DR KEGG; ipu:108256776; -.
DR CTD; 9951; -.
DR OMA; NFQWEME; -.
DR OrthoDB; 10019at2759; -.
DR Proteomes; UP000221080; Chromosome 24.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605:SF11; HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 4; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637359-3};
KW Transferase {ECO:0000256|RuleBase:RU361155}.
FT DOMAIN 149..384
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT ACT_SITE 158
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT BINDING 158..162
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 239
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 247
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 364..368
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT DISULFID 347..359
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-3"
SQ SEQUENCE 413 AA; 46891 MW; 48E12773B17E560B CRC64;
MAFLPGTALL ASKVPRKILF MFTLSLSVTY LFYSLMSCYD SLRFPVLENY AYQAPEVTTL
ATLREKLYST PSRAHLEHEL VATTVTANLL TEKYEVEEIT AAGWERARVE TAVSKSAALN
LEHPETSTMD GGLGRAANCT SDYGEKKLPQ AIIIGVKKGG TRALLEALRV HPDVRAVGNE
PHFFDRNYEK GLDWYRDLMP STLEGQITME KTPSYFVTNS APKRIHTMAK DIKLIIVVRN
PVTRAISDYT QTLSKRPEIP TFEVLAFKNR TLGIIDASWS ALRIGIYALH LENWLQYFPL
SQMHFVSGER LITDPAGEMT KVQDFLGLKR IVTDKHFYFN KTKGFPCLKK PEDSSTPRCL
GKSKGRTHPK IEPDVIRRLH KFYKPFNNMF YQMTGQNFQW EMEDGGDSPG PRD
//
