ID A0A2D0PXA6_ICTPU Unreviewed; 678 AA.
AC A0A2D0PXA6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Potassium voltage-gated channel subfamily KQT member 4 isoform X2 {ECO:0000313|RefSeq:XP_017310674.1};
GN Name=LOC108257428 {ECO:0000313|RefSeq:XP_017310674.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017310674.1};
RN [1] {ECO:0000313|RefSeq:XP_017310674.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017310674.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_017310674.1; XM_017455185.3.
DR AlphaFoldDB; A0A2D0PXA6; -.
DR STRING; 7998.ENSIPUP00000031696; -.
DR Ensembl; ENSIPUT00000032959; ENSIPUP00000031696; ENSIPUG00000021309.
DR GeneID; 108257428; -.
DR OMA; EQMGEAT; -.
DR OrthoDB; 2911641at2759; -.
DR Proteomes; UP000221080; Chromosome 24.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.140.1910; -; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR PANTHER; PTHR47735:SF7; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF03520; KCNQ_channel; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01459; KCNQCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 92..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 167..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 292..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 92..321
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 447..633
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT REGION 32..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 678 AA; 76133 MW; EE5B68604C44EB84 CRC64;
MLGSPSNNGG VRMLAPHAAD DDRRVEFVAL AAVNTEPPSP ERAQPSQRTG LLGTPYPAPP
GPRAAASASN KRYRKIQNCL YNVLERPRGC AFIYHAFIFL LVFSCLVLSV FSTIPTHQET
ANQGLFILEF VMIVVFGLEY IVRVWAAGCC CRYRGCQGRL RFARKPFCII DFIVFVASVA
VIAAGTQGNI FATSALRSMR FLQILRMVRM DRRGGTWKLL GSVVYAHSKE LVTAWYIGFL
VLIFASFLVY LAEKDHNNEF STYADSLWWG TITLTTIGYG DKTPHTWLGR LLAAGFALLG
VSFFALPAGI LGSGFALKVQ EQHRQKHFEK RRTPAATLIQ AAWRLYSTDA RHSYLTATWY
FYDSMLPSFR ELTLLFSHLQ RQRNTKKFLH NYHTLLSGLR PYSSLYVSGD SGKIGFRDRI
KMNSSRSTQA LRSKASSPVP PGSVRQSPSN ENMSEATSPT KVQKSWSFND RTRFRTSLRL
KARPSADVEG VGEENTEDKS YCDVAVEDVI PAVKTLIRAV RILKFLVAKR KFKETLRPYD
VKDVIEQYSA GHLDMLGRIK SLQMRVDQIV GRGAVPSDKR GRTEKGEKTP LELDPLDELS
MMGRVVKVEK QVQSIENKLD LLLNFYSQCL KKGSSHFTLS SLLEPDLTSD YHSPTDQREL
FTSANTLNIS NSDSGNME
//
