ID A0A2D0PXG8_ICTPU Unreviewed; 856 AA.
AC A0A2D0PXG8;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=E3 ubiquitin-protein ligase UNKL isoform X1 {ECO:0000313|RefSeq:XP_017310126.1};
GN Name=unkl {ECO:0000313|RefSeq:XP_017310126.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017310126.1};
RN [1] {ECO:0000313|RefSeq:XP_017310126.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017310126.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the unkempt family.
CC {ECO:0000256|ARBA:ARBA00008808}.
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DR RefSeq; XP_017310126.1; XM_017454637.3.
DR AlphaFoldDB; A0A2D0PXG8; -.
DR GeneID; 108257151; -.
DR KEGG; ipu:108257151; -.
DR CTD; 64718; -.
DR OrthoDB; 1388186at2759; -.
DR Proteomes; UP000221080; Chromosome 24.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16772; RING-HC_UNKL; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR045234; Unkempt-like.
DR InterPro; IPR040594; Unkempt_Znf.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR14493:SF118; RING FINGER PROTEIN UNKEMPT; 1.
DR PANTHER; PTHR14493; UNKEMPT FAMILY MEMBER; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR Pfam; PF00642; zf-CCCH; 1.
DR Pfam; PF18384; zf_CCCH_5; 1.
DR SMART; SM00356; ZnF_C3H1; 4.
DR SUPFAM; SSF90229; CCCH zinc finger; 1.
DR PROSITE; PS50103; ZF_C3H1; 4.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00723}.
FT DOMAIN 112..141
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 152..182
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 280..314
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 322..350
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 815..850
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT ZN_FING 112..141
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT ZN_FING 152..182
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT ZN_FING 280..314
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT ZN_FING 322..350
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT REGION 392..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 693..762
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 392..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 856 AA; 94959 MW; ADD3FD144AE454A4 CRC64;
MRVVFIVTDT PAARDPLKRL PYTAILPYYV HVYIDSEVLS SQVEMDVKES QQQQQQQQQQ
QKQYLKEFRT EQCPLFLQHK CTQHRPFTCF HWHFLNQRRR RPIRRRDGTF NYSPDVYCTK
YDETTGICPD GDDCPYLHRT TGDTERKYHL RYYKTGTCIH ETDARGHCVK NGLHCAFAHG
PHDLRPPVYD IREIQAQEAL QNGQLGSGEG IPDLQPGVLA SQAMIEKTLI EDPRWQDTNF
VLANYKTEQC TKPPRLCRQG YACPHYHNSR DRRRNPRKFK YRSTPCPSVK HGDEWGEPSK
CESGDSCQYC HSRTEQQFHP EIYKSTKCND MKQTGYCPRG PFCAFAHVER IPSTEETMST
LLTAMQSGSQ AKLGSQQYPE CLGSDWSSNT NSISSSTSNN GQMASVSCTN SSTVTSSSGS
TSSLSPIGPI GRPKSFTNGS LCSESTTSSV SSPTSNYPKA PGFEREDQAK NHKGPCGENN
QKITDQDKQS HSSIFSVVNP LASSITSSIT SSLASSIGSD SSSPTTLSTM NAKATPFYPG
SNTVESVIGS ALDLNFNDIS VASLDKDLED QDNNGFVTSQ RLLGGSDPVN IPGSLARCSS
LHSSSSLSAS PLSSLSQSLS QSLLSGMASQ QSQTQGLPVK TEHNLLGTPT STQNSLGLNG
GAGGIWDFMS GSLSPSPSPV FSSSMVSSSS GDLARLLRDL DEAKKKIKQW EDAWHQVKQA
CEAWQKDAKE AKEQAKVAEA ERQLAEQKRK DSELKLKELQ GDFDTLCRSP STPLLRSYGD
LDQLPLPKLH SIQNQLRSDL DLIDGVIYQL QSKKCIVCQK HDRCIVLQPC QHYVLCENCA
PSKTECPYCK TKILKW
//
