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Database: UniProt
Entry: A0A2D0Q017_ICTPU
LinkDB: A0A2D0Q017_ICTPU
Original site: A0A2D0Q017_ICTPU 
ID   A0A2D0Q017_ICTPU        Unreviewed;       934 AA.
AC   A0A2D0Q017;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   11-DEC-2019, entry version 11.
DE   SubName: Full=DNA (Cytosine-5)-methyltransferase 3A isoform X4 {ECO:0000313|RefSeq:XP_017310700.1};
GN   Name=dnmt3a {ECO:0000313|RefSeq:XP_017310700.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|Proteomes:UP000221080, ECO:0000313|RefSeq:XP_017310700.1};
RN   [1] {ECO:0000313|RefSeq:XP_017310700.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017310700.1};
RG   RefSeq;
RL   Submitted (NOV-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC       ProRule:PRU01016}.
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DR   RefSeq; XP_017310700.1; XM_017455211.1.
DR   GeneID; 108257425; -.
DR   CTD; 1788; -.
DR   OrthoDB; 1015783at2759; -.
DR   Proteomes; UP000221080; Genome assembly.
DR   GO; GO:0009008; F:DNA-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR   InterPro; IPR025766; ADD.
DR   InterPro; IPR018117; C5_DNA_meth_AS.
DR   InterPro; IPR001525; C5_MeTfrase.
DR   InterPro; IPR040552; DNMT3_ADD.
DR   InterPro; IPR030487; DNMT3A.
DR   InterPro; IPR000313; PWWP_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases.
DR   PANTHER; PTHR23068:SF10; PTHR23068:SF10; 1.
DR   Pfam; PF17980; ADD_DNMT3; 1.
DR   Pfam; PF00145; DNA_methylase; 1.
DR   Pfam; PF00855; PWWP; 1.
DR   SMART; SM00293; PWWP; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS51533; ADD; 1.
DR   PROSITE; PS00094; C5_MTASE_1; 1.
DR   PROSITE; PS50812; PWWP; 1.
DR   PROSITE; PS51679; SAM_MT_C5; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU01016,
KW   ECO:0000313|RefSeq:XP_017310700.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000221080};
KW   S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU01016};
KW   Transferase {ECO:0000256|PROSITE-ProRule:PRU01016,
KW   ECO:0000313|RefSeq:XP_017310700.1}.
FT   DOMAIN          295..353
FT                   /note="PWWP"
FT                   /evidence="ECO:0000259|PROSITE:PS50812"
FT   DOMAIN          483..615
FT                   /note="PHD-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51533"
FT   REGION          1..270
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..32
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        47..66
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..109
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        110..124
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        134..172
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        185..213
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        726
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ   SEQUENCE   934 AA;  105319 MW;  6F68856C1F59E0AC CRC64;
     MMPSNAAAPT PEFKTSDVDC DAAAKKTSSE QEQEVCEIMQ EEALVDAPAR RVGRPARKRK
     TPTVDSCESL KEGVAGVKEA ECNGENENGV SPGALQGHDS SSASSHQNGS DKADQEESSA
     PSTPRKKRGR RKLEHPEKHV EEDGSSSDTS RGEGDSGRVR TREGRDISLR RRPVPRITFQ
     AGDPFHMSKR EREELIAHWK KEEEEKKAHR TPLMNDTMAD QSEDDAQRNE EQPAVSSVPT
     TPGTPPPQQQ HTDPASPTVA TTPEPASVPV ACGNKELHKS AEAEQEYDDG RGFGIGELIW
     GKLRGFSWWP GRIVSWWMTS RSRAAEGTRW VMWFGDGKFS VVCVEKLLPL SSFSTAFHQP
     TYSKQPMYRK AIYEVLQTAS TRAGKPFPVC MSTDDSETGK SVEHQTREMI EWASGGFMPT
     GAKGLEPPPA ERNPYTEVYP EMWVEPEAAA YTAPAKKPRK NSLEKPKIKE IIDEGTRERL
     VYEVRQKCRN IEDMCISCGS LNVSLEHPLF IGAMCQSCKN CFLECAYQYD DDGYQSYCTI
     CCGGREVLMC GNNNCCRCFC VECVDLLVGT GSAQAAIKED PWNCYMCSSK GVFGMLRRRD
     DWTSRLQLFF ANNHDQDFVS HAIPKHCSTC VHQEPPKIYT PVAAEKRQPI RVLSLFDGIA
     TGLLVLRDLG IQVERYVASE VCEDSITVGM VRHQGRIMYV GDVRNVTHKH IQEWGPFDLV
     IGGSPCNDLS IVNPARKGLF EGTGRLFFEF YRLLHDARPK EGDERPFFWL FENVVAMGVS
     DKRDISRFLE CNPVMIDAKE VSAAHRARYF WGNLPGMNRP LSAMQNDRLD LQDCLEHGRT
     AKFDKLRTIT TRSNSIKQGK DQHFPVYMNN KEDILWCTEM ERYAWIERVF GFPVHYTDVS
     NMSRLARQRL LGRSWSVPVI RHLFAPLKEY FACY
//
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