ID A0A2D0Q1G9_ICTPU Unreviewed; 693 AA.
AC A0A2D0Q1G9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Frizzled-3a isoform X4 {ECO:0000313|RefSeq:XP_017311210.1};
GN Name=fzd3a {ECO:0000313|RefSeq:XP_017311210.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017311210.1};
RN [1] {ECO:0000313|RefSeq:XP_017311210.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017311210.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR RefSeq; XP_017311210.1; XM_017455721.3.
DR AlphaFoldDB; A0A2D0Q1G9; -.
DR GeneID; 108257739; -.
DR CTD; 565921; -.
DR OrthoDB; 5483535at2759; -.
DR Proteomes; UP000221080; Chromosome 25.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF144; FRIZZLED-3 ISOFORM X1; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..693
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012971613"
FT TRANSMEM 214..236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 301..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 427..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 487..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..146
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 209..516
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 580..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..598
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 641..682
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 38..99
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 46..92
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 113..137
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 693 AA; 77804 MW; BA9B44BBDE904B25 CRC64;
MFLAGLKTMD LAWFVLSMLT TCTAINMQSA GSHSTFTCEP IMLRMCQGLP YNTTFMPNLL
NHYDQQTAAL AMEPFHPMVN LDCSADIRPF LCALYAPVCK EYGRVTLPCR QLCQRAKSDC
YKLMDIFGLS WPEEMACNRF PECDEPYPRA EDLLSSANST AESPLSVQRD YGFWCPRELK
VDPELGYRFL GVRDCSPPCP NMYFSRDELV FARYFIAVVS IICLSATLFT FLTFLIDMGR
FRYPERPIVF YSVCYMMVSL VFFLGFLLEE RVACNKAAPG HFRAATVTQG SHNKACTLLF
MALYFFTMAG SAWWVVLTVT WFLAAVPKWG SEAIEKKALL FHAVAWGLPG VLTVTLMALN
RVEGDGVSGV CFVGLYDLTA LRWFLLAPLA LAVTAGVVLL LAGIVALNRV RMEIPLDKEN
QDKLVKFMIR IGVFSVLYLV PLLMVIGCFM YEQSYRPVWE ITWVQEQCRN YHIPCPFKVE
QMSRPNVALF LIKYLMMLVV GIPSVFWVGS KKTCFEWASF FHGHHKKDVV HDSKQVLQEP
DFTQLLLREP GVTVVRQSRG TSTQGTSTHA SSTHLAMLDE AHSGSSRPSS MHSKASSFHS
SRRQSHDGRY TACTVHGAEA LRLPHVSVSR LHEQLQQSST VRLDCQSRHG GSQRLDSQSR
HASIRDLSST QPAVQSGPVN GIHSVTDEIG GTP
//
