GenomeNet

Database: UniProt
Entry: A0A2D0Q1S8_ICTPU
LinkDB: A0A2D0Q1S8_ICTPU
Original site: A0A2D0Q1S8_ICTPU 
ID   A0A2D0Q1S8_ICTPU        Unreviewed;      4859 AA.
AC   A0A2D0Q1S8;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   16-JAN-2019, entry version 5.
DE   SubName: Full=ryanodine receptor 3 isoform X1 {ECO:0000313|RefSeq:XP_017311641.1};
GN   Name=ryr3 {ECO:0000313|RefSeq:XP_017311641.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|Proteomes:UP000221080, ECO:0000313|RefSeq:XP_017311641.1};
RN   [1] {ECO:0000313|RefSeq:XP_017311641.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017311641.1};
RG   RefSeq;
RL   Submitted (NOV-2017) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_017311641.1; XM_017456152.1.
DR   GeneID; 108257968; -.
DR   KEGG; ipu:108257968; -.
DR   CTD; 6263; -.
DR   KO; K04963; -.
DR   OrthoDB; 5161at2759; -.
DR   Proteomes; UP000221080; Genome assembly.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000221080};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_017311641.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000221080};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4402   4422       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4461   4487       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4660   4681       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4736   4759       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      105    160       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      167    212       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      220    274       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      280    328       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      345    404       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      604    802       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1018   1213       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1259   1473       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3938   3964       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      465    485       {ECO:0000256|SAM:Coils}.
FT   COILED     3240   3260       {ECO:0000256|SAM:Coils}.
FT   COILED     3406   3426       {ECO:0000256|SAM:Coils}.
FT   COILED     3600   3620       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4859 AA;  550084 MW;  99EC2A0C9988B389 CRC64;
     MAEGGEGEDE IQFLRTDDEV VLQCVAAIQK ENRKFCLSAE GLGNRLCYLE PTSEAKYVPP
     DLCICNFVLE QSLSVRALQE MLANTGPNGE GNPDHERWAG QGGGHRTLLY GHAILLRHSF
     SGMYLACLKT SRSLTDKLSF DVGLQEDSSG EACWWTIHPA SKQRSEGEKV RIGDDLILVS
     VSSERYLHLS ISNGNIQVDA SFMQTLWNVQ PTCSGSNVAV GYLLGGHVLR LFHGHDESLT
     IPGADQSTEQ QRLVNYETGK SGSRARSLWR LEPLRISWSG SHIRWGQPFR LRHLSTGHYL
     GQTEDRGLEL VDREISDTAS TAFCFRPSKE KVDSGPKRDI DGMGVAEIKY GDSVCFIMHV
     ASGLWLSYQA PDAKSSRLGP LKRRAFLYPE GHMDDGLILQ LCQHEESRAA RIIRNTTQLF
     TQFIRGLDEL KGEKAPGVSL PVGELLQTLN DLITYFQQPD SELEHEEKQR QLRSLIKRQD
     LFKEEGMLTL VSICIDRLNM YNSAAEFEEF AGEEAGEAWK DILNLFYELL AALIRGNRPN
     CTQFSRKLDW LVSKLERLES SSGILEALHC ILTESPEALN IIQKDHIRSI ISLLYKHGRN
     HKILDILCSL CVCNGVAVRA NQNIICDHLL PRRDLLLQTR LVNDVQSMRP NIFLGVSEGS
     AQYKKWYFEL MIDQVDHFVT SEATHLRVGW ASTKGYAPYP GGGEGWGGNG VGDDLYSYAF
     DGLHLWSGRI PRAVASINQH LLTSDDVVSC CLDLGAPSMS FRINGQPVQG MFEDFNTDGF
     FFPVVSFSAG VKVRFLLGGR HGDFKFLPPA GYAPCYEALL PKEKMRVEPV KEYKRDVEGV
     RNLLGTTQFL SQASFIPIPV NTSQIVLPPH LENVRDKLAE NIHELWGMNK IELGWTYGKV
     RDDNKRQHPC LVDFSKLPET EKNYNLQMST ETLKTLLALG CHVVQINVNA EDDLKKIKLP
     KDYVMSNGYK PSPLELSDVK LTPGQEVLVD KLAENAHNVW AKDRIKQGWT YGIQQDLKSR
     RNPRLVPYSL LDERTKKSNR DSLREAIRTL IGYGYNIEPP DQEAAHVVEK RSVENIRFFR
     VEKSYAVKSG KWYYEFEAVT GGEMCVGWAR PSCRPDVELG MDDQAYVFDG YRGRRVHMGS
     HFFGRTWSKG DVVGCMINME DKSMIFTLNG EILITNKGSE LCFTDFDADD GFIPVCSLGL
     SQIGRMNLGK DASTFKYYTM CGLQEGFEPF AVNMNREVTM WFSKRLPTFV NVPADHEHIE
     VTRIDGTVDS PPCLNVSHKT FGTQASNNDM IYCRLSMPVE FYSSPRKITN VNEVISDGQK
     SKKDNSGKTD YGSITKYFYS VRVFAGQDPA SVWVGWVTPD YHYYSKNFNL SKVRTVTVTL
     GDERGRVHES VRRSNCYMVC AGDISSSSSG RSNADLIIGC HIDLASGLVS FTANNKELPI
     AYQVEPNTKL FPAVFVQPTS PNLFQFEFPK IKDAMPLSSA IFKSLHSNPE PQCPPRLDVQ
     TIVAVLWSRM PNTFLSVETA RVSERHGWVL QCLEPLQMMA VHIPEENRCI DIMELSEDEA
     LRQFHYHTLK LYCALCALGN TRVAHALCSH LDQSQLLYTI DNQYLTGQLR EGFYDVLISI
     HLETAKEAQL MMKNEFIIPI TDETCSIHLF SDDSKRHSLP GVGLSTSLSP RLNFSPACFI
     TTKREHLYSP QIPLGILKEK AISMLTEAVQ GGGTHIRDPV GGSVEYQFVP ILKLIATLLI
     MGSLTSEEVR IILLLIEPNV FGESKEEETQ LVAAEEPAEK EEASSNEEKA VEAGEEESKE
     HKQPPKGLLE KSLPESVKHQ MCELLHYFCD CELKQRIEAI VAFSDSFVAK LQYNQKFRYN
     ELMQALNMSA AVTAKKTKEF RSPPQEQINM LLDFSAGEDC PCPEDIQEEL HAFHEDLRLH
     CGIPMEEEEE EPDTSIKGRL LSLLYKIKGR PQKTEEQPSE EKQAAPTNLK ELISQTMVSW
     AQECKMQNPA LVRSMFSLLR RQYDGIGELL RAMRKSYTIS EKSVQDAINL LASLGQIRSL
     LSVRMGEEEG QLMIDGLGDI MNNKVFYQHP NLMRVLGMHE TVMEVMVNVL GGDKSKEIAF
     PKMVASCCRF LCYFCRISRE NQKAMFEHLS YLLENSSVGL ACPAMRGSTP LDVAASSVMD
     NNSLALALEE PDLEKVVTYL AGCGLQSCPM LVAKGYPDIG WNPIEGERYL SFLRFAVFVN
     GESVEENANV VVKLLIRRPE CFGPALRGEG GQGLLAAMLE AIKISEDPAL DLPNLPEGGA
     PVSGEDGEEE EEVAHMGNSI MSFYSALIDL LGRCAPEMHL INTGKGEALR IRAILRSLVP
     TKDLVGIISI PLKVPVLNKD GSVTEPDMNA SFCPEHKSPM VLFLDRVYGI EDQSFLLNLL
     EVGFLPDFRV SASLDTEVLS TTETALALNR YIGSAVLPLL TRCAHLFAHT EHYATLMDST
     LHTIYRLSKG RSLTKAQRDS IEECLLAICK HLRPSMLQQL LRRLVFDVPQ LTEYCKMPIK
     LLTNHYEQNW KYYCLPSGLG SYGMASEEEL HLTKKLFWGL FDALSQKKYD AELFKMAMPC
     LSAIGGAIPP DYVDMSPANT LVKQASVDGQ GNFDPKPIST ANISLPEKLD YIANKYAEHC
     HEKWSSEKFA LGWTAGEKVD DQAKTHPLLK QYKALSEKER ETYRYPVKES LKSMLAMGWT
     IERTKEGEAM FQQRESGKQI SEASQGDGFH PAPVDLENVI LSRELQSMVE TVAENYHNIW
     AKKKKMELSS KGGGTHPLLV PYDTLTAKEK FRDREKAQEL FKFLQINGYA ISRGLKDIEQ
     DSSSMEKRIA YKFLKRLLSY VDSAQEFIAH LEAMASSGKT DKSPHEQEIK FFAKVLLPLL
     DQYFKNHCLY FLSSPSINLS SSGYASNKEK EMITSLFYKL ASLVRHRISL FGSDSATMVS
     CLHILAHSLD FRTVMKSGSE LVKAGVRTFF ENAAEDLEKT VENLKLGKLG QSRTQMKGVA
     QIINYTSVAL LPILTALFQH ITEHQFGADL LLDDVQLSCY RILTSLYSLG TGKNIYVEKQ
     LPVLGECLAT LVGAMPVAFL EPHLNMHNPR SVFNTKTPRE RAILSMPDTV EEMCPEMPRL
     DGLMKDIHDI SESGARYTEM PHVIEVILPL LCNYLSYWWE KGPENSPSHV SCCTTVTSEH
     LSLILGNILK ILNNNLGIDE ASWMKRLAVY TQPIISKAGA DLLRTHFLPT LEKLKKKTVK
     VVAEEEMIRA ESRADTQEAE LQILDEFAVL CRDLYAFYPM LIRYVDNNRS KWLKKPNADS
     TELFKMVSEI FILWCKSHNF KREEQNFVVQ NEINNLAFLT GDSKTKMSKS GGQDQERRGK
     KRKRELYSIQ TSLIVAAHKK LLPIGLNMCT AGDQELISLA KIRYSLKDTD DEVKDHLRQN
     LHLQEKTEDP AVQWQLNLYK DVEVKSEEPL NTDHIIEKIQ GISAAVFHLD QVEQPLRCKK
     LTWQKQLSKQ RKRAVVACFR MAPLYNLPRH RSINLFLMGY QKLWIVAEEY SFEEKLVQDL
     AKTPMAAEKE EEEAEAEVQP DPLNQLILHF SHNALTERSV LEVDPLYIAY ADMMAKSCAE
     DEEEEEEEGK EKTFEEKEME KQKILYQQAR LHARGAAEMV LQMISASKGR LGPMVTFTLK
     LGISILNGGN VVVQQKMLDY LKDKRDAGFF KSLSGLMQSC SVLDLNAFER QKKAESLGMV
     TEEGSVNVSE RGSKVLQNDE FTKDLFRFLQ LLCEGHNDDF QNFLRTQTGN TTTVNIIIST
     VDYLLRLQES ISDFYWYYSG KDIIDEHGQL NFSRALAVAK QIFNSLTEYI QGPCIGNQQS
     LAHSRLWDAV VGFLHVFANM QMKLSQDSSQ IELLKELMDL QKDMVVMMLS LLEGNVVNGT
     IGKQMVDTLV ESSSNVEMIL KFFDMFLKLK DLTTSDNFKE YDPEGKGIIS KKEFQKSMES
     QKQYTQSEIE FLLSCAEADE NDMFNYMEFV ERFHEPAKDI SFNVAVLLTN LSEHMPHDSR
     LATFLDLAES VLGYFEPYLG RIEIMGGAKR IERVYFEISQ SSREQWEKPQ VKESKRQFIF
     DMVNEGSESE KMELFVNFCE DTIFEMQLAS QISEPGAVER PEEEEEPHSL LEDLSEEEDQ
     SLESASAFTV ACNSLKNKIS QFRQTLTLKN MRKQFKKFKK LTIKEMITGF FLFFWMLFTG
     FFKGIFSLIF GFFHIIWSSM FGGGLVEGAK NMKVTDILGN MPDPTQFGIH GDVMEPEKAE
     NGEIVVSTEM VQMVGTVDKL EADAIIDLIS PPTKREGKHG HEPGLGDVSE IMTEASPRVE
     KKKRQKAAAE EFEPEKADTE NHEKEDKAKE EKPEEPVVEE IPAPRKRRGP TKEEPPALMA
     AFFAGLEVYK TKMLNYLARN FYNLRMLALF VAFAINFILL FYKVTGEADD EEEEESWGGG
     GDDDDDDDDI EFYVLQESTG YMAPTLTFLA ILHTVISLLC VVGYYCLKVP LVVFKREKEI
     ARKLEFDGLY ITEQPSDDDI KGQWDRLVIA TPSFPNNYWD KFVKRKVINK YGDLYGAERI
     AELLGLDKSA LDFDPTEEAV VKEASLLSWL SSIDTKYHIW KMGVVLTDNS FLYLIWYTTM
     SILGHYNNFF FAAHLLDIAM GFKTLRTILS SVTHNGKQLV LTVGLLAVVV YLYTVVAFNF
     FRKFYNKSED DDAPDMKCDD MMTCYLFHMY VGVRAGGGIG DEIEDPAGDP YELYRILFDI
     TFFFFVIVIL LAIIQGLIID AFGELRDQQE QVKEDMETKC FICGIGNDYF DTTPHGFETH
     TLQEHNLANY LFFLMYLINK DETEHTGQES YVWKMYQERC WDFFPAGDCF RKQYEDQLG
//
DBGET integrated database retrieval system