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Database: UniProt
Entry: A0A2D0Q2R4_ICTPU
LinkDB: A0A2D0Q2R4_ICTPU
Original site: A0A2D0Q2R4_ICTPU 
ID   A0A2D0Q2R4_ICTPU        Unreviewed;      4846 AA.
AC   A0A2D0Q2R4;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   16-JAN-2019, entry version 5.
DE   SubName: Full=ryanodine receptor 3 isoform X5 {ECO:0000313|RefSeq:XP_017311645.1};
GN   Name=ryr3 {ECO:0000313|RefSeq:XP_017311645.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|Proteomes:UP000221080, ECO:0000313|RefSeq:XP_017311645.1};
RN   [1] {ECO:0000313|RefSeq:XP_017311645.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017311645.1};
RG   RefSeq;
RL   Submitted (NOV-2017) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   RefSeq; XP_017311645.1; XM_017456156.1.
DR   GeneID; 108257968; -.
DR   CTD; 6263; -.
DR   OrthoDB; 5161at2759; -.
DR   Proteomes; UP000221080; Genome assembly.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000221080};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_017311645.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000221080};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4389   4409       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4448   4474       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4647   4668       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4723   4746       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       98    153       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      160    205       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      213    267       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      273    321       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      338    397       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      597    795       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1011   1206       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1252   1466       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3925   3951       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      458    478       {ECO:0000256|SAM:Coils}.
FT   COILED     3233   3253       {ECO:0000256|SAM:Coils}.
FT   COILED     3399   3419       {ECO:0000256|SAM:Coils}.
FT   COILED     3593   3613       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4846 AA;  548464 MW;  8A28C3DCDC722BD6 CRC64;
     MAEGGEGEDE IQFLRTDDEV VLQCVAAIQK ENRKFCLSAE GLGNRLCYLE PTSEAKYVPP
     DLCICNFVLE QSLSVRALQE MLANTGPNGE GAGQGGGHRT LLYGHAILLR HSFSGMYLAC
     LKTSRSLTDK LSFDVGLQED SSGEACWWTI HPASKQRSEG EKVRIGDDLI LVSVSSERYL
     HLSISNGNIQ VDASFMQTLW NVQPTCSGSN VAVGYLLGGH VLRLFHGHDE SLTIPGADQS
     TEQQRLVNYE TGKSGSRARS LWRLEPLRIS WSGSHIRWGQ PFRLRHLSTG HYLGQTEDRG
     LELVDREISD TASTAFCFRP SKEKVDSGPK RDIDGMGVAE IKYGDSVCFI MHVASGLWLS
     YQAPDAKSSR LGPLKRRAFL YPEGHMDDGL ILQLCQHEES RAARIIRNTT QLFTQFIRGL
     DELKGEKAPG VSLPVGELLQ TLNDLITYFQ QPDSELEHEE KQRQLRSLIK RQDLFKEEGM
     LTLVSICIDR LNMYNSAAEF EEFAGEEAGE AWKDILNLFY ELLAALIRGN RPNCTQFSRK
     LDWLVSKLER LESSSGILEA LHCILTESPE ALNIIQKDHI RSIISLLYKH GRNHKILDIL
     CSLCVCNGVA VRANQNIICD HLLPRRDLLL QTRLVNDVQS MRPNIFLGVS EGSAQYKKWY
     FELMIDQVDH FVTSEATHLR VGWASTKGYA PYPGGGEGWG GNGVGDDLYS YAFDGLHLWS
     GRIPRAVASI NQHLLTSDDV VSCCLDLGAP SMSFRINGQP VQGMFEDFNT DGFFFPVVSF
     SAGVKVRFLL GGRHGDFKFL PPAGYAPCYE ALLPKEKMRV EPVKEYKRDV EGVRNLLGTT
     QFLSQASFIP IPVNTSQIVL PPHLENVRDK LAENIHELWG MNKIELGWTY GKVRDDNKRQ
     HPCLVDFSKL PETEKNYNLQ MSTETLKTLL ALGCHVVQIN VNAEDDLKKI KLPKDYVMSN
     GYKPSPLELS DVKLTPGQEV LVDKLAENAH NVWAKDRIKQ GWTYGIQQDL KSRRNPRLVP
     YSLLDERTKK SNRDSLREAI RTLIGYGYNI EPPDQEAAHV VEKRSVENIR FFRVEKSYAV
     KSGKWYYEFE AVTGGEMCVG WARPSCRPDV ELGMDDQAYV FDGYRGRRVH MGSHFFGRTW
     SKGDVVGCMI NMEDKSMIFT LNGEILITNK GSELCFTDFD ADDGFIPVCS LGLSQIGRMN
     LGKDASTFKY YTMCGLQEGF EPFAVNMNRE VTMWFSKRLP TFVNVPADHE HIEVTRIDGT
     VDSPPCLNVS HKTFGTQASN NDMIYCRLSM PVEFYSSPRK ITNVNEVISD GQKSKKDNSG
     KTDYGSITKY FYSVRVFAGQ DPASVWVGWV TPDYHYYSKN FNLSKVRTVT VTLGDERGRV
     HESVRRSNCY MVCAGDISSS SSGRSNADLI IGCHIDLASG LVSFTANNKE LPIAYQVEPN
     TKLFPAVFVQ PTSPNLFQFE FPKIKDAMPL SSAIFKSLHS NPEPQCPPRL DVQTIVAVLW
     SRMPNTFLSV ETARVSERHG WVLQCLEPLQ MMAVHIPEEN RCIDIMELSE DEALRQFHYH
     TLKLYCALCA LGNTRVAHAL CSHLDQSQLL YTIDNQYLTG QLREGFYDVL ISIHLETAKE
     AQLMMKNEFI IPITDETCSI HLFSDDSKRH SLPGVGLSTS LSPRLNFSPA CFITTKREHL
     YSPQIPLGIL KEKAISMLTE AVQGGGTHIR DPVGGSVEYQ FVPILKLIAT LLIMGSLTSE
     EVRIILLLIE PNVFGESKEE ETQLVAAEEP AEKEEASSNE EKAVEAGEEE SKEHKQPPKG
     LLEKSLPESV KHQMCELLHY FCDCELKQRI EAIVAFSDSF VAKLQYNQKF RYNELMQALN
     MSAAVTAKKT KEFRSPPQEQ INMLLDFSAG EDCPCPEDIQ EELHAFHEDL RLHCGIPMEE
     EEEEPDTSIK GRLLSLLYKI KGRPQKTEEQ PSEEKQAAPT NLKELISQTM VSWAQECKMQ
     NPALVRSMFS LLRRQYDGIG ELLRAMRKSY TISEKSVQDA INLLASLGQI RSLLSVRMGE
     EEGQLMIDGL GDIMNNKVFY QHPNLMRVLG MHETVMEVMV NVLGGDKSKE IAFPKMVASC
     CRFLCYFCRI SRENQKAMFE HLSYLLENSS VGLACPAMRG STPLDVAASS VMDNNSLALA
     LEEPDLEKVV TYLAGCGLQS CPMLVAKGYP DIGWNPIEGE RYLSFLRFAV FVNGESVEEN
     ANVVVKLLIR RPECFGPALR GEGGQGLLAA MLEAIKISED PALDLPNLPE GGAPVSGEDG
     EEEEEVAHMG NSIMSFYSAL IDLLGRCAPE MHLINTGKGE ALRIRAILRS LVPTKDLVGI
     ISIPLKVPVL NKDGSVTEPD MNASFCPEHK SPMVLFLDRV YGIEDQSFLL NLLEVGFLPD
     FRVSASLDTE VLSTTETALA LNRYIGSAVL PLLTRCAHLF AHTEHYATLM DSTLHTIYRL
     SKGRSLTKAQ RDSIEECLLA ICKHLRPSML QQLLRRLVFD VPQLTEYCKM PIKLLTNHYE
     QNWKYYCLPS GLGSYGMASE EELHLTKKLF WGLFDALSQK KYDAELFKMA MPCLSAIGGA
     IPPDYVDMSP ANTLVKQASV DGQGNFDPKP ISTANISLPE KLDYIANKYA EHCHEKWSSE
     KFALGWTAGE KVDDQAKTHP LLKQYKALSE KERETYRYPV KESLKSMLAM GWTIERTKEG
     EAMFQQRESG KQISEASQGD GFHPAPVDLE NVILSRELQS MVETVAENYH NIWAKKKKME
     LSSKGGGTHP LLVPYDTLTA KEKFRDREKA QELFKFLQIN GYAISRGLKD IEQDSSSMEK
     RIAYKFLKRL LSYVDSAQEF IAHLEAMASS GKTDKSPHEQ EIKFFAKVLL PLLDQYFKNH
     CLYFLSSPSI NLSSSGYASN KEKEMITSLF YKLASLVRHR ISLFGSDSAT MVSCLHILAH
     SLDFRTVMKS GSELVKAGVR TFFENAAEDL EKTVENLKLG KLGQSRTQMK GVAQIINYTS
     VALLPILTAL FQHITEHQFG ADLLLDDVQL SCYRILTSLY SLGTGKNIYV EKQLPVLGEC
     LATLVGAMPV AFLEPHLNMH NPRSVFNTKT PRERAILSMP DTVEEMCPEM PRLDGLMKDI
     HDISESGARY TEMPHVIEVI LPLLCNYLSY WWEKGPENSP SHVSCCTTVT SEHLSLILGN
     ILKILNNNLG IDEASWMKRL AVYTQPIISK AGADLLRTHF LPTLEKLKKK TVKVVAEEEM
     IRAESRADTQ EAELQILDEF AVLCRDLYAF YPMLIRYVDN NRSKWLKKPN ADSTELFKMV
     SEIFILWCKS HNFKREEQNF VVQNEINNLA FLTGDSKTKM SKSGGQDQER RGKKRKRELY
     SIQTSLIVAA HKKLLPIGLN MCTAGDQELI SLAKIRYSLK DTDDEVKDHL RQNLHLQEKT
     EDPAVQWQLN LYKDVEVKSE EPLNTDHIIE KIQGISAAVF HLDQVEQPLR CKKLTWQKQL
     SKQRKRAVVA CFRMAPLYNL PRHRSINLFL MGYQKLWIVA EEYSFEEKLV QDLAKTPMAA
     EKEEEEAEAE VQPDPLNQLI LHFSHNALTE RSVLEVDPLY IAYADMMAKS CAEDEEEEEE
     EGKEKTFEEK EMEKQKILYQ QARLHARGAA EMVLQMISAS KGRLGPMVTF TLKLGISILN
     GGNVVVQQKM LDYLKDKRDA GFFKSLSGLM QSCSVLDLNA FERQKKAESL GMVTEEGSGS
     KVLQNDEFTK DLFRFLQLLC EGHNDDFQNF LRTQTGNTTT VNIIISTVDY LLRLQESISD
     FYWYYSGKDI IDEHGQLNFS RALAVAKQIF NSLTEYIQGP CIGNQQSLAH SRLWDAVVGF
     LHVFANMQMK LSQDSSQIEL LKELMDLQKD MVVMMLSLLE GNVVNGTIGK QMVDTLVESS
     SNVEMILKFF DMFLKLKDLT TSDNFKEYDP EGKGIISKKE FQKSMESQKQ YTQSEIEFLL
     SCAEADENDM FNYMEFVERF HEPAKDISFN VAVLLTNLSE HMPHDSRLAT FLDLAESVLG
     YFEPYLGRIE IMGGAKRIER VYFEISQSSR EQWEKPQVKE SKRQFIFDMV NEGSESEKME
     LFVNFCEDTI FEMQLASQIS EPGAVERPEE EEEPHSLLED LSEEEDQSLE SASAFTVACN
     SLKNKISQFR QTLTLKNMRK QFKKFKKLTI KEMITGFFLF FWMLFTGFFK GIFSLIFGFF
     HIIWSSMFGG GLVEGAKNMK VTDILGNMPD PTQFGIHGDV MEPEKAENGE IVVSTEMVQM
     VGTVDKLEAD AIIDLISPPT KREGKHGHEP GLGDVSEIMT EASPRVEKKK RQKAAAEEFE
     PEKADTENHE KEDKAKEEKP EEPVVEEIPA PRKRRGPTKE EPPALMAAFF AGLEVYKTKM
     LNYLARNFYN LRMLALFVAF AINFILLFYK VTGEADDEEE EESWGGGGDD DDDDDDIEFY
     VLQESTGYMA PTLTFLAILH TVISLLCVVG YYCLKVPLVV FKREKEIARK LEFDGLYITE
     QPSDDDIKGQ WDRLVIATPS FPNNYWDKFV KRKVINKYGD LYGAERIAEL LGLDKSALDF
     DPTEEAVVKE ASLLSWLSSI DTKYHIWKMG VVLTDNSFLY LIWYTTMSIL GHYNNFFFAA
     HLLDIAMGFK TLRTILSSVT HNGKQLVLTV GLLAVVVYLY TVVAFNFFRK FYNKSEDDDA
     PDMKCDDMMT CYLFHMYVGV RAGGGIGDEI EDPAGDPYEL YRILFDITFF FFVIVILLAI
     IQGLIIDAFG ELRDQQEQVK EDMETKCFIC GIGNDYFDTT PHGFETHTLQ EHNLANYLFF
     LMYLINKDET EHTGQESYVW KMYQERCWDF FPAGDCFRKQ YEDQLG
//
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