ID A0A2D0Q361_ICTPU Unreviewed; 2378 AA.
AC A0A2D0Q361;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Fibronectin {ECO:0000256|ARBA:ARBA00020368};
GN Name=fn1b {ECO:0000313|RefSeq:XP_017312744.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017312744.1};
RN [1] {ECO:0000313|RefSeq:XP_017312744.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017312744.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_017312744.1; XM_017457255.3.
DR GeneID; 108258550; -.
DR CTD; 334613; -.
DR OrthoDB; 5399734at2759; -.
DR Proteomes; UP000221080; Chromosome 26.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR CDD; cd00061; FN1; 11.
DR CDD; cd00062; FN2; 2.
DR CDD; cd00063; FN3; 15.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 12.
DR Gene3D; 2.10.10.10; Fibronectin, type II, collagen-binding; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 16.
DR InterPro; IPR000083; Fibronectin_type1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR000562; FN_type2_dom.
DR InterPro; IPR036943; FN_type2_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013806; Kringle-like.
DR PANTHER; PTHR46708:SF8; FIBRONECTIN; 1.
DR PANTHER; PTHR46708; TENASCIN; 1.
DR Pfam; PF00039; fn1; 11.
DR Pfam; PF00040; fn2; 2.
DR Pfam; PF00041; fn3; 15.
DR PRINTS; PR00013; FNTYPEII.
DR SMART; SM00058; FN1; 12.
DR SMART; SM00059; FN2; 2.
DR SMART; SM00060; FN3; 16.
DR SUPFAM; SSF49265; Fibronectin type III; 11.
DR SUPFAM; SSF57603; FnI-like domain; 12.
DR SUPFAM; SSF57440; Kringle-like; 2.
DR PROSITE; PS01253; FN1_1; 5.
DR PROSITE; PS51091; FN1_2; 11.
DR PROSITE; PS00023; FN2_1; 1.
DR PROSITE; PS51092; FN2_2; 2.
DR PROSITE; PS50853; FN3; 16.
PE 4: Predicted;
KW Acute phase {ECO:0000256|ARBA:ARBA00022486};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell shape {ECO:0000256|ARBA:ARBA00022960};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00479}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Signal {ECO:0000256|SAM:SignalP};
KW Sulfation {ECO:0000256|ARBA:ARBA00022641}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..2378
FT /note="Fibronectin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012564881"
FT DOMAIN 47..86
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 91..134
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 135..178
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 180..224
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 225..269
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 353..401
FT /note="Fibronectin type-II"
FT /evidence="ECO:0000259|PROSITE:PS51092"
FT DOMAIN 413..461
FT /note="Fibronectin type-II"
FT /evidence="ECO:0000259|PROSITE:PS51092"
FT DOMAIN 466..509
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 514..556
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 557..600
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 604..696
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 712..802
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 803..892
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 899..991
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 992..1081
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1082..1168
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1169..1260
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1262..1356
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1357..1443
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1444..1534
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1541..1631
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1633..1723
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1724..1813
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1816..1906
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1909..1999
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2100..2193
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2200..2244
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 2245..2287
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 2289..2329
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DISULFID 358..384
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT DISULFID 372..399
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT DISULFID 418..444
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT DISULFID 432..459
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
SQ SEQUENCE 2378 AA; 261862 MW; 58826B297CB0E88A CRC64;
MRRLVLLALC ACSAVVCVPK SGRNKRQQQQ QVLPGIPVEE LAYTRQAVCT ENGRFYQVND
QWERPYMGST LLCTCKGSAG IQCESKPAGE EMCFDKVNAR SYRVGETYER PKDGMIWDCT
CIGSGRGKIS CTIANRCHEG GRSYRIGETW TRPHDTGDYM LECVCLGNGK GEWTCKPIAE
RCYDTSVGAS YVVGQTWEKP YQGWMIVDCT CLGEGNGRIT CTSRNRCNDQ DMRKSYRIGE
TWTKVDSQGR AQQCVCTGNG RGEWKCESHT SAQTALGSGS GLSTQVKPVT HQLNILPVLA
EIGTCQTRSG TIYYDGMRWV QTQGSQQMIC TCVNGGIGCE EWDGQSHVYG GNSNGQPCVF
PFTFGGKTHY SCISEGRTDG QLWCSTTSDY DTDRQYSFCT QRNLMVTTRG GNSNGALCQF
PFLYNGRNYT DCTADGRRDG MKWCGTTANY DDERRYGFCP MAAHEEICTV NDVMYRLGDE
WDKRHDTMGH MMRCKCVGNG RGEWSCVAHS QIRDQCIVDG LTYEVDQTFD KRHNEGYMMN
CTCFGQGRGR WKCDAIDQCQ EAETKVFYQI GETWDKVSHG VRYRCTCYGN GIGEHACEPL
ESRVPVRVTI TETGNQPNSH PIQWNPPASA HITQYILKWK VKNTRTPWRE VIIPSHINSY
TISGLKPGLT YEGQLISILN YGHREVTRFD FTTSSGSLVP TEGVTTQNTR VLDTSESITE
ITSSSFVVSW TSASETISGF RVQYELSEEG AEPTVIDLPR TSTSVNIDRL LPGRTYHVQV
YEVEPEGDTN LILTTTQTTA PDTPSDHRVT EVRETSIVIS WTKPHAPITG YRVVYTPSVE
GSSTELNLPE TVTSVTLVDL QPGQSYNVSI FAVEGNLESE AVVLQVRTAG ESQPEEVQAP
TELQFYEVTD VKITITWTGP PSEVSGYRVT YEPVSSDGHS TQRPLALPTT PNAYAEITHL
QPGTLYRFYV YAVYGGAESQ PLVGEKSTRP DAPTDLRFPD VTEDTVLVVW SAPQARITGY
RLYITTEDST SPTLLRIRPE ETQYTVPNLQ PDTMYTVTLH SEHGSTLSEG VSGTVTTTVP
IGNAPRFSTD VTDSSIIISW TPVPRFSYRM SVKPSQGGEA PRVVTSDSGS IYISGLTPGV
EYTYSLQPII NGRKQGNAIT RNVVTPLSPP SDLNLVSNPN TGDLSVRWRE STTPDITGYR
VTCTPTLGQR ANSLEEFVRG QQTSCTLENL SPGVEYNVSV YTVKNHIESE PISSVITQGV
PAPTNLKFGE VGPDSMRLSW TRPSVRQSEI SRFVIRYHPS NDDDNIQEVN VGGATSTYLL
QHLLPVTEYV VSVSCVYGQR ESTPVTGRQT TNLDSPSGLV FSDVFTHSFT ANWQAPRAPI
TGYRLAYEAT SGGRRQEERL PPSRTRYALN NLQPNTLYTL RIYAVSGRQE SQPLTGTQAT
ISDAPTDLEV TSSTPNSITI SWDAPAIPVR YYRIKHEQTG ERGSGQEFTV PGTESTATIG
GLQPGTDYTV TIYAVTGRGD SPASSTPTII THRTGSHGVP SPSDLDVTDI QDQAIVVRWS
PARGPITGYR VTGSPKNGVG PTFSKEVGPD QTELRITGLV PTVEYVISVY AIGRDGKSTP
VVERATTIKP TDSPTDLTFS DVDSSSVRVS WRPPQGRVTS YRVFYSSPET GEREWSPAPS
RNDDNVLLQH LRPGTEYSVR VIATTDRGAT AELAGTHTTV VPAPTNIQFG DVGPSSFVVL
WRAPGIRLNG YRVLVKPKNN IAQPKELNVA PDSMQVTVTG LLVSTVYEVY VYALKDSVSS
PPLVGEVTTT GEDISPPRRP RVNEVKDTSI TLNWRAKIEP ITGFLIEATP ISGNYPTIRK
EIPGEHRSAV ITGLHPGTAY KINIYTLNGD RRSAPFTLST NTIGSSLQPP TDLRFQALSP
TSISFNWQPP TSHITGYYIT YEEEGSSPRE LTPRPHAGTN YATITGLKPA TVYIIKIIAL
QNTLRSPPLV GKARTQESLL LPLPIPPRHN TLGPLDVPET DILVNVVGPT VQPGPGEGGQ
GMEYTEYNNQ PTLPHSGHRP NPYVPGTGQT LIYVPAPGPD GSRVPKVVQL SDRNAHGFTF
PENKTGTPQE AQTQTTVSWQ PFRQSKAYLV TCHPVTQRNE KMFQLQLPST STSATLIGLT
SGASYRVLVE ALKDALKYKI LDEVITAGNT DPAGVPASDD SCYDTLTATH HNIGDEWERM
SETGFKLWCR CLGLGSGHFR CDSSKWCHDN GHNYLIGERW ERRAENGHMM SCTCLGNGKG
EFKCEPHEST CYDEGKTYQV GNQWQKEYLG AICTCICYGG QQGWRCENCK KPGTEINTHL
LKPVRYGDGI AKVNIHCPIE CLRPDILADA VANPNPLE
//
