ID A0A2D0Q3C2_ICTPU Unreviewed; 657 AA.
AC A0A2D0Q3C2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Histone-lysine N-methyltransferase SETDB2 {ECO:0000256|ARBA:ARBA00040299};
DE EC=2.1.1.366 {ECO:0000256|ARBA:ARBA00039052};
DE AltName: Full=SET domain bifurcated 2 {ECO:0000256|ARBA:ARBA00042995};
GN Name=setdb2 {ECO:0000313|RefSeq:XP_017312790.1,
GN ECO:0000313|RefSeq:XP_017312792.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017312792.1};
RN [1] {ECO:0000313|RefSeq:XP_017312790.1, ECO:0000313|RefSeq:XP_017312792.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017312790.1,
RC ECO:0000313|RefSeq:XP_017312792.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-
CC methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3]
CC + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60288, Rhea:RHEA-
CC COMP:15538, Rhea:RHEA-COMP:15541, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961,
CC ChEBI:CHEBI:61976; EC=2.1.1.366;
CC Evidence={ECO:0000256|ARBA:ARBA00036635};
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_017312789.1; XM_017457300.1.
DR RefSeq; XP_017312790.1; XM_017457301.3.
DR RefSeq; XP_017312792.1; XM_017457303.3.
DR STRING; 7998.ENSIPUP00000016479; -.
DR Ensembl; ENSIPUT00000017176; ENSIPUP00000016479; ENSIPUG00000011157.
DR Ensembl; ENSIPUT00000017187; ENSIPUP00000016490; ENSIPUG00000011157.
DR Ensembl; ENSIPUT00000017211; ENSIPUP00000016513; ENSIPUG00000011157.
DR GeneID; 108258587; -.
DR KEGG; ipu:108258587; -.
DR CTD; 83852; -.
DR OMA; IIFEQVQ; -.
DR OrthoDB; 2877903at2759; -.
DR Proteomes; UP000221080; Chromosome 26.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 2.170.270.10; SET domain; 2.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR46024; HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS; 1.
DR PANTHER; PTHR46024:SF3; HISTONE-LYSINE N-METHYLTRANSFERASE SETDB2; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00468; PreSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000256|ARBA:ARBA00022776};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 335..401
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
FT DOMAIN 404..632
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 498..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..531
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 657 AA; 73658 MW; F21A1C12629A15BE CRC64;
MELSAVERAK TFWSQVDVDL AFEELLGFLM CLREAIKNKA ASDKGYVQGM NIIMESEVSL
TAALRSDSFE EVLIGEGVIV GEDILTVSVS DSHCTILKMK DLPVPEDALH DDVSRNLESG
SDNSQMSSSG RNDAMLLGKL DTYDYMMLLS PANVLSDDQL APVSPVQLSY QQHDCSPACL
PHLPSHSDTF LGHNPLQVPL LCHFQRHCAK PLMLSPHEEL DSNVLYKAPC GRSLRRMDDV
YQFLQQTKSL GVLHQTNFSF NSQVLPERQA QPRPLAPASP LPTTSISERD ISRGIESVPV
TLCNDLDGVR PKEFRYRKDR WPHGCFLSTA PFFLSCCDCT DGCTDSSSCL CLQLSLKAGA
KPDRLYSHHR LNEPVSTGLY ECGPWCGCPK SSCQNRVVQH GLRVRLQVFR TNDKGWGVRC
RDDLDKGTFV CTYAGVVLRL GRNLEEPLLS KIQKEEQLSD DEVEVVEEWT LPSGQKKTVT
ETLDTSPRPY VLVIQRPADQ PSAPLDGQRE QLENSDNQEE MNTCSSPNPS HTEIKHQHKE
EVVRKRLRLD GEENGGDVRR DQMVPKPDCQ EKMYYLDASK EGNVGRFINH SCNPNLFVQN
VFVDTHDPKF PVIAFFTCKP IRAGTELTWN YSYKTGSDPE HEVQCLCGSN DCQTIII
//
