ID A0A2D0Q437_ICTPU Unreviewed; 1245 AA.
AC A0A2D0Q437;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Adhesion G-protein coupled receptor G6 isoform X11 {ECO:0000313|RefSeq:XP_017313062.1};
GN Name=adgrg6 {ECO:0000313|RefSeq:XP_017313062.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017313062.1};
RN [1] {ECO:0000313|RefSeq:XP_017313062.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017313062.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_017313062.1; XM_017457573.3.
DR AlphaFoldDB; A0A2D0Q437; -.
DR GeneID; 108258671; -.
DR CTD; 57211; -.
DR OrthoDB; 3026989at2759; -.
DR Proteomes; UP000221080; Chromosome 2.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00041; CUB; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001759; Pentraxin-related.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF290; ADHESION G-PROTEIN COUPLED RECEPTOR G6; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00159; PTX; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00059};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_017313062.1};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..1245
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012338743"
FT TRANSMEM 859..882
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 894..913
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 919..943
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 963..985
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1011..1037
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1058..1080
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1086..1109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..147
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 857..1110
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1179..1204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 92..109
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
SQ SEQUENCE 1245 AA; 137723 MW; B10C0EBC3856A3D7 CRC64;
MVSYISGRWW RWKFWNVLQV AVFLTCIART EVLSCQGECD EMLTASSGIF TSPCYPNDYP
SRQACTWTLQ APAGFVLQLT FLDFELEEAQ GCIYDSVIVN TGTSSVKFCG LTANGLTLNS
STNVMEVSFH SDFSVQKKGF NISYRQVAVA LRNQKVTLPQ NQKDVVQVSS SVSIPALSQF
TACFEIAGQS STGSGIIFSY TGKDPYLTFG HNGNSVDLII GNVTCPVSDL VTLADITSIM
QLFCITWSNT NGVIAVYFKG NYKFKTCSNS IGMRTEIGGS FELGRGKKQG QNFNCLIYNF
RLWSSAMTFS ELSSLTCDAV GNVVDWNNSF WDIPASYAQT DSSLSCICYP QCAHLTTTLS
SIGTAVPATT SQTTSCLSSG VGCPDLPITT SYTTTPSISL TTTSEFTYYR ISLLVSDDLP
ITDDFITQWL NQTFQDWNHT IYVSNVSILP GTDSSITTSR RYTYKAVLVY KNTTGKLLTD
ADIKNRLKSV STASFTLDNI AVNAVENCLA EETPLHYKWP ESRPSVTLFI PCFPYKEQNA
SRTCMISPEN YSSFWDQPDL MNCKDIEDIE VSQENAAEVA VQLADITNNE LSTVELSKVV
TVVTKLVNVA RINVSLASTV VTIISNVMIS SESVQLAASE MALKTMDMLV QKIEFDGPSL
TITSKNLAVG ISAINSSSFS GANFSASMAQ NSSDPQIDFE SEVHNSLASV LLPATLLHNL
SEADVEIISR IHFMFFSKTG LFQHFGSLMD QQNNGLALNS YVVASSVGNI SISNLKDPVQ
IEIAHLQHQW NPNRLCVFWD FSIENGSGGW NSEGCQVSPE SNSNKTVCLC NHLTHFGVLM
DLSGAAAHID ARNTKILTFI TYIGCGISAI FSAVTILTYV AFEKLRRDYP SKILMNLSTS
LLFLNMTFLL DSWLASYDMQ GLCMAVAAFL HFFLLTSFTW MGLESIHMYI ALVKVFNTYI
RRYILKFCIV GWGLPAVIVA LVVAVDKNSY GKEFYGQGEN GEGFCWIQSK VVFYVTCVAY
FCIIFVLNVA MFIVVMMQIC GRNGKRNNRT LQEEVLRNLR SVISLTFLLG MTWGFAFFAW
GPVNVAFMYL FSIFNSLQGL FIFIFHCALK ENVQKQWRRY LCCGKLRLAD NSDWSKTATN
NTKKVSSDNI GKSLSSSSFG STTVNWTSKA RVTLNPFAKR HSSSGKPYSN QANQKCSTSD
SDASTSSILP VHQVLDKVKG YCSVRSDNFY KNIILSDSFS HSTKF
//
