ID   A0A2D0Q5D4_ICTPU        Unreviewed;      1061 AA.
AC   A0A2D0Q5D4;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Insulin receptor substrate 2a {ECO:0000313|RefSeq:XP_017313514.1};
GN   Name=irs2a {ECO:0000313|RefSeq:XP_017313514.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017313514.1};
RN   [1] {ECO:0000313|RefSeq:XP_017313514.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017313514.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_017313514.1; XM_017458025.3.
DR   AlphaFoldDB; A0A2D0Q5D4; -.
DR   STRING; 7998.ENSIPUP00000020253; -.
DR   Ensembl; ENSIPUT00000021124; ENSIPUP00000020253; ENSIPUG00000013753.
DR   GeneID; 108258957; -.
DR   KEGG; ipu:108258957; -.
DR   CTD; 393285; -.
DR   OMA; HMSRSNT; -.
DR   OrthoDB; 4212441at2759; -.
DR   Proteomes; UP000221080; Chromosome 26.
DR   GO; GO:0005158; F:insulin receptor binding; IEA:InterPro.
DR   GO; GO:0008286; P:insulin receptor signaling pathway; IEA:InterPro.
DR   CDD; cd01257; PH_IRS; 1.
DR   CDD; cd01204; PTB_IRS; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   InterPro; IPR039011; IRS.
DR   InterPro; IPR002404; IRS_PTB.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10614; INSULIN RECEPTOR SUBSTRATE; 1.
DR   PANTHER; PTHR10614:SF7; INSULIN RECEPTOR SUBSTRATE 2; 1.
DR   Pfam; PF02174; IRS; 1.
DR   Pfam; PF00169; PH; 1.
DR   PRINTS; PR00628; INSULINRSI.
DR   SMART; SM01244; IRS; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00310; PTBI; 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   PROSITE; PS51064; IRS_PTB; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Receptor {ECO:0000313|RefSeq:XP_017313514.1}.
FT   DOMAIN          21..122
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          156..260
FT                   /note="IRS-type PTB"
FT                   /evidence="ECO:0000259|PROSITE:PS51064"
FT   REGION          256..302
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          323..348
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          373..420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          435..484
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          602..626
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        265..302
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        331..348
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        435..480
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1061 AA;  115999 MW;  C0D5BE492FA433D5 CRC64;
     MASPPLTGGT SLSNVNMYSN NVKKSGYLKK QKHGHRRFFV LKEQSDCLPA RLEYYESEKK
     WKNKSAAKRV VSLDSCLSIN KRADAKHRYL IALYTKDEYF AVAAENESEQ ESWYRDLTNL
     MNEGKVYDSA VTNSASSLVG FDEGNYGMIT PVNAAYKEVW QVNLKSKGLG QTRNITGVYR
     LCLSSRSISF VKLNTEVPSV SLQLMNIRRC GHSDSFFFIE VGRSASTGPG ELWMQADDSV
     VAQNIHETIL EAMKAMKESS EFRPRSKSQS SGSNPISVPT RRNLNNLPPS QTGLVRRSRT
     DSVAATSPIN KFTSCRIRTA SEGEGTMARP VSMSVSENGS PTVRNHMSRS NTVSVGCRTF
     EASLLHHNRS MSMSVPVSHS RSSPISPLSL SSTSVNGSTS TSAVHKPSSC SGSVSGSPSD
     TGFLSCDEYG SSPGDAKYNA SNRSNTPSSF SGTPPSREST DIHGYTMMES PSSHSLNKVQ
     ASSREKLDLE KLYRKRTYSL TAPQQPKTPS QQSSASLDEY MLMWAVYANG HTGQSTHTVS
     PKVSYPEDYG DLEIGSSRGS VSNQGDDGYM PMTPGGALQG SKNDHYVPMS PMCVSAPKQI
     INPRSHPQTT GRQGTINSPS TGSLEDNGYM RMWSGSKSSL DSTDARVTNG EYMNMSPVDL
     HVSATPPDYF LGGCAPAQRP SSLLNLNKHE GPKREEDQYV LMCPQGHKRG EETNCNAMFM
     ANPGLSFSSP STLLPLRHSR NDGLLHRARV SRQNRLSLDT LRMLPRMNEH PLPSEPKSPG
     EYINIDFSDT ARYSLPSGSV ESQASSPSLG SIRRRSPLCD YMNLDLNSHS PKSEETLASS
     LHDIPELTNC PCSSDDGTYV PDEQNSSCSP STRKDDYAEM KFDNATSIIT ENDETDMASP
     TNRVQRLILS DKSMPGIGAF LLPNSTVDPD GEAKVIRADP RGRRRHSSET FSSTTTVMPV
     FPSFAHSCKR HSSASVENVS VRSSEGSDEE CGSPMCKETS AGFQDGLNYI ALNLMENREF
     GNCENMMGFK PIGCYKGGLN GLHDSPYVSL GFKETVTTVK D
//