ID   A0A2D0Q8U4_ICTPU        Unreviewed;       197 AA.
AC   A0A2D0Q8U4;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=BCL2 associated X, apoptosis regulator b isoform X2 {ECO:0000313|RefSeq:XP_017314714.1};
GN   Name=baxb {ECO:0000313|RefSeq:XP_017314714.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017314714.1};
RN   [1] {ECO:0000313|RefSeq:XP_017314714.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017314714.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the Bcl-2 family.
CC       {ECO:0000256|ARBA:ARBA00009458}.
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DR   RefSeq; XP_017314714.1; XM_017459225.3.
DR   AlphaFoldDB; A0A2D0Q8U4; -.
DR   GeneID; 108259599; -.
DR   CTD; 503609; -.
DR   OrthoDB; 4251693at2759; -.
DR   Proteomes; UP000221080; Chromosome 2.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   Gene3D; 1.10.437.10; Blc2-like; 1.
DR   InterPro; IPR036834; Bcl-2-like_sf.
DR   InterPro; IPR046371; Bcl-2_BH1-3.
DR   InterPro; IPR026298; Bcl-2_fam.
DR   InterPro; IPR002475; Bcl2-like.
DR   PANTHER; PTHR11256; BCL-2 RELATED; 1.
DR   PANTHER; PTHR11256:SF65; BCL2 ASSOCIATED X, APOPTOSIS REGULATOR A-RELATED; 1.
DR   Pfam; PF00452; Bcl-2; 1.
DR   PRINTS; PR01862; BCL2FAMILY.
DR   SMART; SM00337; BCL; 1.
DR   SUPFAM; SSF56854; Bcl-2 inhibitors of programmed cell death; 1.
DR   PROSITE; PS50062; BCL2_FAMILY; 1.
PE   3: Inferred from homology;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        169..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          54..149
FT                   /note="Bcl-2 Bcl-2 homology region 1-3"
FT                   /evidence="ECO:0000259|SMART:SM00337"
SQ   SEQUENCE   197 AA;  21933 MW;  47CCC7FD26286392 CRC64;
     MDGQIGEALI IRVIQDQMMN VNIGGNLSLP CLPEVQPLAS VQDQKLLDQL AQSVKVIGDK
     LNQEHSLNDQ IDGLARLGDR KIFSKLVDGV FYDGQINWGR IIVLFYAVGK LAVKMVLANL
     PTVFSEILES CLDFFRTKLL IWIRNMDGWI SSISALTQFS IEHISASSFY TIPSPVVAFF
     CGILLGSIIV WKFRISS
//