ID A0A2D0Q9W3_ICTPU Unreviewed; 1750 AA.
AC A0A2D0Q9W3;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=TP53-binding protein 1 isoform X3 {ECO:0000313|RefSeq:XP_017314170.1};
GN Name=tp53bp1 {ECO:0000313|RefSeq:XP_017314170.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017314170.1};
RN [1] {ECO:0000313|RefSeq:XP_017314170.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017314170.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_017314170.1; XM_017458681.3.
DR STRING; 7998.ENSIPUP00000034074; -.
DR Ensembl; ENSIPUT00000035411; ENSIPUP00000034074; ENSIPUG00000022895.
DR Ensembl; ENSIPUT00000035465; ENSIPUP00000034126; ENSIPUG00000022895.
DR GeneID; 108259309; -.
DR CTD; 7158; -.
DR OMA; HASCHAN; -.
DR OrthoDB; 5403076at2759; -.
DR Proteomes; UP000221080; Chromosome 27.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR CDD; cd17745; BRCT_p53bp1_rpt1; 1.
DR CDD; cd17724; BRCT_p53bp1_rpt2; 1.
DR CDD; cd20383; Tudor_53BP1; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR InterPro; IPR015125; 53-BP1_Tudor.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR047249; BRCT_p53bp1-like_rpt1.
DR InterPro; IPR047250; BRCT_p53bp1-like_rpt2.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR047252; TP53BP1-like.
DR PANTHER; PTHR15321:SF3; TP53-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR15321; TUMOR SUPPRESSOR P53-BINDING PROTEIN 1; 1.
DR Pfam; PF09038; 53-BP1_Tudor; 1.
DR Pfam; PF18428; BRCT_3; 1.
DR SMART; SM00292; BRCT; 2.
DR SUPFAM; SSF52113; BRCT domain; 2.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 2.
DR PROSITE; PS50172; BRCT; 2.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 1516..1632
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 1647..1742
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 49..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 110..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 153..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 408..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 819..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 895..919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 949..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1006..1093
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1162..1288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1433..1508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..237
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..510
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 512..528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..576
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..620
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..665
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..688
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..726
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..743
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..771
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 785..804
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 900..919
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 960..988
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1006..1066
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1162..1176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1271..1288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1441..1460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1461..1476
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1750 AA; 188278 MW; 1CDD0009DB5F15C3 CRC64;
MDPGGSDLES SLPQTENPCL IVEDSQPDSV ALEDDPDSSY RALLSRRLSN LQPTSHSPVL
ELIASPSKGR CTESDSQTEK SNSVIEADHF PSNLSSAAAE HSQVFEVCSL PNSKRNQEDM
ESGADSTTHC AQTEEGVSQF GLLELSESQG LNIEAQNIES GDEDVEVTPA NLRPADSPKT
TNQTGLKSSS RESDSQDDRF RRPEVSSSSA LVPQRREGRE LSVQDILHSR VSESVEDEDM
DVMSSQDDMF DGERNGSKVD STVAELENQQ EQHQQDPTCT PAHSLRLLHL SGQQTLVQES
LSQQSVDFVA ATQDNISQTP HIVPNSPTGQ ENEQDFNEAA APAKDTPGTP NDQAQKGQEE
PMDVDPVPKP TVSNVVSQNS PSIALEKSLS LPSQPEFSHD VFVPTPSLES GVCSQGPEAL
KKKEAPKESP STILEAEAFK KPADCQPSQV ATCFQLELDS ENSVFDKKTQ VFTVDDDSQA
TQIEIQGPIG EDERDSVPVH RNEKTDKSSM DCGLNKAANL QGISQEPDLK TTENEECSSQ
KPSLQSSKGQ NGKINDSVAK SQEIQCTSNT VASQQMDEGG LGKDLTLSSC SQSKEQAGKP
TSTMPVPSES QSQSVIFSHK NPPGEEQGVE RDQRLSQPVS QSHRLESFSN TKDVDEDRMD
EGEVQSTSRT EGSGFGLALS QSQVNSPEPK AEDGGEDAQS AGSKDEESLS VVVLEESERI
SQEQEHVEKS PVFSCSSQPV KGSPKEKSGP DRKVAGSQPN SLGQNLQVAS RAGASKAPAS
DGAPSGGSQV LNVANKSLSD SSGDLPFHFT LPREGELIGP AASATPPHVR QLKNTPLHST
PIETSTFHER TEAGVTRETT MAASEISVEE SGEGEELAAQ GGDGKLSLRM KVVTPVEEGS
SGSERFSLQK PSLSDEEGSV TKATAVSKAV TSPQSIFTRV REVHRQLQVE GEEMEPSDLS
LRRLSQTALP SSESLDLSPE AVGNGTPEQL LQQTNGTVLH SEPLAKVQSS TAKEHEAPST
SGQAPRKSLP GQRAMSQQTS VGLSSAASPL SKRAASQQTS FDASGPQLPS GRGEPVTPTR
SQSGPSHRRH IRTIQEVRTT ITRIITDMYY EDGREVDRKV VEESDEPVVD RCVIDSDVSP
SRTGSSMTSG DLADVSSLSS KTASHFSSSG TSSGGPAPSR IADFVMPPSR GAKTGSPRRG
GRQAVGLELT GVWGSPFTAP LTPRGHGRRG RPPSRGPLSR GGRSAQRGGG AHGPAVSSSE
DEHLARTNAR VPSSRLDTLN TMSPENSAGS SSFIGLRVMA KWSSNSFFYS GTITRDLGEN
RFRLLFDDNQ ECEAQGKDIL LCDPIPLETE VTALTEEEYF NTGIVKAYKR QGAELLYCVE
KDGQSTWYSR TAVILTLDQG NRLREHYGLG PYEPSTPQNM ASDISLDNLV EGKRRRRGNG
NGPGTPSSSS ANSPRTPAKR KLTSSTEDER TPAKRGRRGG GARSGLRMAP CDTSGSGAEM
PSDTNDLLVS HGPLPESTSL FMGFVFMLTA SSDNDRKSNQ TTSDGEEEYV PTAPYNKQYT
ERQLEAGGGM ILPEFNEEQC KAAYQSLLIA DKHCRTQTYL LCVAGGVPCV SQIWVRDCCQ
EKKLMNYRNY LLPAGVGPEK RIVEWHARCN PFKALKVLLV SEERVDLWTS LLTMCGAAKV
QQHKLSSNSS DISAEGLDLV VSACPAEVLK CVTALNTPVV SLEWLVQCVI CGERLAYDSQ
PEYHHDYSSS
//
