ID A0A2D0Q9X1_ICTPU Unreviewed; 1458 AA.
AC A0A2D0Q9X1;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Rho guanine nucleotide exchange factor 12 isoform X3 {ECO:0000313|RefSeq:XP_017315493.1};
GN Name=arhgef12b {ECO:0000313|RefSeq:XP_017315493.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017315493.1};
RN [1] {ECO:0000313|RefSeq:XP_017315493.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017315493.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004370}.
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DR RefSeq; XP_017315493.1; XM_017460004.3.
DR STRING; 7998.ENSIPUP00000034002; -.
DR GeneID; 108260059; -.
DR CTD; 571031; -.
DR OrthoDB; 2875542at2759; -.
DR Proteomes; UP000221080; Chromosome 28.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR015212; RGS-like_dom.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR PANTHER; PTHR45872:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12; 1.
DR PANTHER; PTHR45872; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF09128; RGS-like; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 66..143
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 782..972
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1014..1127
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 26..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 224..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 610..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1126..1229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1286..1349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1364..1388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..673
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..731
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1132..1151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1158..1181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1210..1229
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1286..1304
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1458 AA; 162748 MW; 4590BB3B0B0E9EB8 CRC64;
MHRSDAEARS TCIGLRRWIT IRFPKKPTRP GSILNKDHPP DKKPKSEKVS VPPTHDFDPT
GLVQRCVIIQ KDENGFGLTV SGDNPVFVQL VKEDGAAMRA GVQTGDRIIK VNGTLVTHSN
HVEVVELIKS GSYVALTVLG RPPGLPQIPL SEGEGDGDPL SSLSSPHSPG PTVAERSSSS
STSPSDRITS PLPAWAMKEE YGRNPTARLL KDIQEAQKHI PLLQGQLGKA TTAGQDGLLS
RRPGEGDSEE GGGLGDVDAS PSWHFDSESP VNSNSTPVTP SMIPESPYQR DTPCHSPKPM
PRFSLNSCPS PDGEDAVDLD SSYQCSAGSP LSRLPPPIIG AEDDDFDTEQ EQVNGQCSCF
QTMELLKSRP AHLAVFLHHV VSQFDPAPLL CYLYAELYKQ SNPKETRRIY GELHSTFMDR
SAQLKVAVPD SISADMERWK PDLIPEDVQR QHVQHLQDTF LPDIQKHLED FRQKRSMGLT
LAEAELSRLD SERVRDRAAL EKERSCSEHI ITRINEVLLT TSATEEEKCT AMQFVIQAYM
KHLGVKVKES RGFEPKPKLI NLLPKIKKTI KPEKDGGVEV LKKSRFQIMR SHNKRPSRTD
VSSITKALEQ NKQRTQKQLS QNALAPTEQP EAPSAGRIRS SQSSDGPDGS PGSINSPTFS
ASPVQSSDST ARELEPGATP LSALPRLGEV GPQAEGQDSS SSGTHFDFTY PPDHLQEEEP
ETDRNPDGGT PRPIRRMEPL CTGEVQSEDD QAFEVEPEQD PPHWQTLVST EVLALLSPHE
IKRQEVINEL FYTERAHLRM LKVLDNVFYQ RMTRESILPP ADIKNIFTNL EEIVQLHVSI
TEQMTAIRKK YETAVVDLIG DDLLSWFSGT EEEKIKRAVG TFCSNQPFAL ELIKSRQKKD
QRFAAFVQEA ESNRQCRRLQ LKDMIPVEMQ RLTKYPLLLE NIAKYTDDTE EKSKVKRACE
CCRQILNHVN QEVKEAENKQ RLEDYQRRLD LSSLKQSEYP MIAEFKNLNL TKRKMVHEGP
LSWKVNKDKT IELYTLLLED ILVLLQRQDE KLILKCHSKN LAGTAETKHI FSPIIKLSTV
LVRSVATDNK SFFVVSMSDY GAQIYELMAQ TVSEQKTWHD LIGQRADSMK SLPQNDGERE
ADDEMNSGMP KMSKDPDRIS TGSVQSPEKD ATSSTEIMQI PPAGSNPFDT KSEDEEEAEG
EHLPQVQDEV QDEVQDEVQD EAEEDEEEAF LDPELADRLP FLKQRSRHAI AVEEKDLDTF
DLPPLMADEA LRTLAALRQL LINHMDGQED VDRDRERGEA RLRELKAGSL QGSEENAAPG
GSVENGAERT ETAHVKSENR LELPSGDTGF FETSEDFGSY MVLEGYGGSG ESSTDDDGQV
CSTEPAAAGD SGIDLKKLLS SVSSQSRGPN FSRQIMTHLR LLQANLQHLK DVESKYNQLC
QRHSEQAATE SEENKDKS
//
