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Database: UniProt
Entry: A0A2D0QAV2_ICTPU
LinkDB: A0A2D0QAV2_ICTPU
Original site: A0A2D0QAV2_ICTPU 
ID   A0A2D0QAV2_ICTPU        Unreviewed;       795 AA.
AC   A0A2D0QAV2;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   08-MAY-2019, entry version 10.
DE   RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
GN   Name=LOC108259490 {ECO:0000313|RefSeq:XP_017314510.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|Proteomes:UP000221080, ECO:0000313|RefSeq:XP_017314510.1};
RN   [1] {ECO:0000313|RefSeq:XP_017314510.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017314510.1};
RG   RefSeq;
RL   Submitted (NOV-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU046415}.
CC       Nucleus {ECO:0000256|RuleBase:RU046415}.
CC   -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC       {ECO:0000256|RuleBase:RU046415}.
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DR   RefSeq; XP_017314510.1; XM_017459021.1.
DR   GeneID; 108259490; -.
DR   KEGG; ipu:108259490; -.
DR   KO; K11220; -.
DR   OrthoDB; 327469at2759; -.
DR   Proteomes; UP000221080; Genome assembly.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.532.10; -; 1.
DR   Gene3D; 2.60.40.630; -; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR001217; STAT.
DR   InterPro; IPR022752; STAT1_TAZ2-bd_C.
DR   InterPro; IPR036535; STAT_N_sf.
DR   InterPro; IPR013800; STAT_TF_alpha.
DR   InterPro; IPR015988; STAT_TF_coiled-coil.
DR   InterPro; IPR013801; STAT_TF_DNA-bd.
DR   InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR   InterPro; IPR013799; STAT_TF_prot_interaction.
DR   PANTHER; PTHR11801; PTHR11801; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF12162; STAT1_TAZ2bind; 1.
DR   Pfam; PF01017; STAT_alpha; 1.
DR   Pfam; PF02864; STAT_bind; 1.
DR   Pfam; PF02865; STAT_int; 1.
DR   SMART; SM00964; STAT_int; 1.
DR   SUPFAM; SSF47655; SSF47655; 1.
DR   SUPFAM; SSF48092; SSF48092; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|RuleBase:RU046415};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000221080};
KW   Cytoplasm {ECO:0000256|RuleBase:RU046415};
KW   DNA-binding {ECO:0000256|RuleBase:RU046415};
KW   Nucleus {ECO:0000256|RuleBase:RU046415};
KW   Phosphoprotein {ECO:0000256|RuleBase:RU046415};
KW   Reference proteome {ECO:0000313|Proteomes:UP000221080};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191,
KW   ECO:0000256|RuleBase:RU046415};
KW   Transcription {ECO:0000256|RuleBase:RU046415};
KW   Transcription regulation {ECO:0000256|RuleBase:RU046415}.
FT   DOMAIN      571    667       SH2. {ECO:0000259|PROSITE:PS50001}.
FT   COILED      140    184       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   795 AA;  91685 MW;  CB5CF6A7923BFA60 CRC64;
     MSQWLELQQL DSKFLEQVDQ LYDDNFPMAI RQYLSNWIES HDWDHVANVE NESLATVRFH
     DLLTQLDHQH SRFAMEKDFL NQHNIRKIKR NLQTLFGDNP VSMAMIISKN LTEERKILAT
     AQISESSTHN AQSDMMIEKQ RELDSKVKDI KTKVQETEQN IKNLEDLQDE HDFKSKTLQS
     HEELNGTISP EDLNREKLYL KAMFMKLNDM RGGVVGQLSE VLNLVEQLEY ELITVELSEW
     KGRQQMSCIG GLTNVCLDQL QNWFTALGEC LLQVHQQLKK LLELEQKYSY HQDPITLSRG
     SLEERALTQL KTLITNSMVV ERQPCMPTQL QRPLVLKTGV LFTLKVRLLV KLQEFNHTVR
     VKVHLDKDVT EKRKGFRKFN ILGTNMKVMN MEESIGMAAE FRHLQLKEQK VAGNRTNEGP
     LIVTEELHSF TFEAELCWSG LVINFETSSL PIVVISNVSQ LPCGWASIMW YNMLTSDPKN
     LSFFVSPPSV SWGQLSEVLS WQFSSITKRG LNAEQLSMLG HKLLGPKAAK DPEAQIPWNK
     FCKGGSEKNF TFWLWIEGIL DLIKRHLLSL WDEGCIMGFV TKERTKSLLN DKAPGTFLLR
     FSESNRDGAI TFSWVEHTPN GEPQVRSVEP YTKKELSAVS LADILRNYRV MAADNVPEDP
     LRFLYPNTPK DDAFCKYYSK PADKHEPMDV DKKSDDYIRT TLISVSEMQN QRKRLLNSEM
     LHGNPGWSPQ HQVQQVTSNQ HVCSQHEQKT SEYNDIMMPL SPEVYGELER MVRSTLNHTR
     DLTGDLGELC CNLDE
//
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