ID A0A2D0QFG2_ICTPU Unreviewed; 941 AA.
AC A0A2D0QFG2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Solute carrier family 12 member 6 isoform X4 {ECO:0000313|RefSeq:XP_017317039.1};
GN Name=LOC108260881 {ECO:0000313|RefSeq:XP_017317039.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017317039.1};
RN [1] {ECO:0000313|RefSeq:XP_017317039.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017317039.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR RefSeq; XP_017317039.1; XM_017461550.3.
DR AlphaFoldDB; A0A2D0QFG2; -.
DR GeneID; 108260881; -.
DR OrthoDB; 5490251at2759; -.
DR Proteomes; UP000221080; Chromosome 29.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF66; SOLUTE CARRIER FAMILY 12 MEMBER 6; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 3.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 33..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 59..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 417..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 207..499
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 513..631
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 645..751
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 874..941
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 766..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..796
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 941 AA; 104816 MW; 36BDA593D5B87EAA CRC64;
MEWYQMYMAP SAAIFYSQQP EGEAAAMLNN MRVYGSIFLL LMSLLVFVGV KYVNKLASLF
LACVILSILS IYTGALVSAF SPPSFPVCML GNRSISRHEL HDDLCAKTVL TDSNINVNIS
ENFNGTEAPP FTPSKVEKTT NLWLRFCNSS KLNAACDEYF MNNNVTKIEG IPGLASGVIA
ENLWSSYHSK GDLLEQGSNP TPSSASTYPS HHLPYIFVDI TTSFTLLVGI FFPSVTGIMA
GSNRSGDLKD AQRSIPIGTI LAILTTSLVY LSSVVLFGAC VKGVLLRDKF GDSVKGNLVV
GTLAWPSPWV IVIGSFFSTC GAGLQSLTGA PRLLQAIAKD NIIPFLRVFG HGKANGEPTW
ALLLTAFIAE LGILIASLDL VAPILSMFFL MCYLFVNLAC ALQTLLRTPN WRPRFSYYHW
TLSFLGMVIC LALMFISSWY YAIVAMVIAS MIYKYIEYNG AEKEWGDGIR GLSLSAARFA
LLRLEEGPPH TKNWRPQLLV LLKLDEDAHV KSPRLLTFAS QLKAGKGLTI VGTVITGNFL
YAYGESLAAE QTLKHLMEKE RVKGFVQCIV AQKLREGISH MIQSSGLGGM RPNAVVMGWP
HAWRQNEDPQ SWKTFINTVR LTTAAHLALM VPKNISLFPT NSEPNTDGYI DVWWIVHDGG
MLMLLPFLLR QHKVWRKCGM RIFTVAQMED NSIQMKKDLA TFLYHLRIEA EVEVVEMHDS
DISAYTYERT LMMEQRSQML RQMRLSKSDR DREVLSCGEE TVNCSPIHSA ERSNNYEDRG
SESEGETEKN RAQLVKDRNS MLRLTSIGSD DDDDTDGGTE KFSGAAENRR VHMTWTKDKA
LELRAQAHIP SGCSTPEGFR DMLSIRPDHS NVRRMHTAVK LNEVIVNKSH DARLVLLNMP
GPPKNPEGDE NYMEFLEVLT EGLERVLLVR GGGSEVITIY S
//
