ID   A0A2D0QFS7_ICTPU        Unreviewed;       544 AA.
AC   A0A2D0QFS7;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Zinc transporter 6 isoform X1 {ECO:0000313|RefSeq:XP_017317157.1};
GN   Name=slc30a6 {ECO:0000313|RefSeq:XP_017317157.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|RefSeq:XP_017317157.1};
RN   [1] {ECO:0000313|RefSeq:XP_017317157.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017317157.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBUNIT: Heterodimer with SLC30A5; form a functional zinc ion
CC       transmembrane transporter. {ECO:0000256|ARBA:ARBA00038600}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC       {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   RefSeq; XP_017317157.1; XM_017461668.3.
DR   AlphaFoldDB; A0A2D0QFS7; -.
DR   STRING; 7998.ENSIPUP00000009846; -.
DR   Ensembl; ENSIPUT00000010280; ENSIPUP00000009846; ENSIPUG00000006723.
DR   GeneID; 108260936; -.
DR   KEGG; ipu:108260936; -.
DR   CTD; 55676; -.
DR   OrthoDB; 11451at2759; -.
DR   Proteomes; UP000221080; Chromosome 29.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1510.10; Cation efflux protein transmembrane domain; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   NCBIfam; TIGR01297; CDF; 1.
DR   PANTHER; PTHR46531; ZINC TRANSPORTER 6; 1.
DR   PANTHER; PTHR46531:SF1; ZINC TRANSPORTER 6; 1.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   SUPFAM; SSF161111; Cation efflux protein transmembrane domain-like; 1.
PE   4: Predicted;
KW   Ion transport {ECO:0000256|ARBA:ARBA00022906};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW   Zinc {ECO:0000256|ARBA:ARBA00022906};
KW   Zinc transport {ECO:0000256|ARBA:ARBA00022906}.
FT   TRANSMEM        110..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        139..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        172..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        213..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        277..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          432..461
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        432..457
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   544 AA;  59948 MW;  6EE28E77400F3E33 CRC64;
     MAMDGMSTSA AGLPYHHVSE YYTRKLGPKP DVVPSGVTER KIGPADKPDM VSVDVINFKD
     SDTPVHRKKQ ETDTHALGTI HPFRKSHKSI FSKFIQEFNL VTSDRRSWKI LLFGMLNVIC
     TASLLMWCNS TNSMALTAYT YLTIFDLFSL ITCLMSSWVT MKKPSQAFSF GFERFEVLAV
     FASTVLVQLG ALFILKESVE RFMEQPEVHT GRLLVGTFVA LFFNLLTLLS IKNKPFVYVS
     EAASTSWLQE HVADLSQSLC GIVPALSSIL LPRMNPFVLI NLAGAFALGI TYMLIEINNY
     NAVDTVSAVA IALMTFGTMY PMSVYSGKVL LQTTPSHVIG QLDKVLREVS TLDGVLEVRN
     EHFWTIGFGS LAGSVHVRIR RDANEQMVLA HVTNRLHTLV STLTVQIFKD DWVHPSLSTG
     PLNLSDITVS SGKQLEEPEP LTSTPSKPSS PPEFSFNTPG RNVRPVLLPN IHQQRPYNLG
     LAYGSSPFNT MLSQGLTQPG SSLGVGLGTG PRIPSVQSYR TSFSAAPNIY GSNLLPSQSS
     QYKH
//